Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q64UC1 (Q64UC1_BACFR) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Dihydroorotate dehydrogenase EMBL BAD48908.1
Gene names
Ordered Locus Names:BF2161
OrganismBacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]
Taxonomic identifier295405 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135

Catalytic activity

(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135

Cofactor

Binds 1 FMN per subunit By similarity. SAAS SAAS012135

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135

Subunit structure

Monomer By similarity. SAAS SAAS012135

Ontologies

Keywords
   Biological processPyrimidine biosynthesis SAAS SAAS012135
   Cellular componentMembrane SAAS SAAS012135
   LigandFMN SAAS SAAS012135
Flavoprotein SAAS SAAS012135
   Molecular functionOxidoreductase SAAS SAAS012135
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' pyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

UMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotate oxidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1781Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
Q64UC1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 7C9FE3DE3D74AF2F

FASTA33136,900
        10         20         30         40         50         60 
MYKQTIRPVL FLMEPEKVHA LLVSCLKCYR HLPWCRCWMR HLYTCSDKQL IWNHLTFRNR 

        70         80         90        100        110        120 
IGLSAGFDKG AEIFDELADC GFGFIEVGTV TPDSQDGNPR PRIFRLPQCE SLISRTGFNN 

       130        140        150        160        170        180 
PGLDVIKRRL EQKSGSYVLG VNINKNPSSE GEQAVADFLR LYKELHPHVG YFTLNWGSVD 

       190        200        210        220        230        240 
VALMKQVLQG LAAFRVEQNI HVPLLLKLPA DITEEGMDDV IDCTRLYRVD GVIATGPTME 

       250        260        270        280        290        300 
RSYLKGYSPA QLQKIGSGGI SGRGIGERSL KAVSYLRAHA GKSLLIVGAG GIITPADARR 

       310        320        330 
MLDAGANLIQ IYSSFIYEGP GIVKKMIQEI K

« Hide

References

[1]"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YCH46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006841 Genomic DNA. Translation: BAD48908.1.
RefSeqYP_099442.1. NC_006347.1.

3D structure databases

ProteinModelPortalQ64UC1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3084162.
GenomeReviewsGene locus BF2161 in contig AP006841_GR.
KEGGbfr:BF2161.
NMPDRfig|295405.3.peg.1817.
PATRIC21049974. VBIBacFra17906_2099.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG351027.
OMASYVTVNI.
ProtClustDBPRK05286.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01036. PyrD_sub2. 1 hit.
PROSITEPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ64UC1_BACFR
AccessionPrimary (citable) accession number: Q64UC1
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info