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Reviewed, UniProtKB/Swiss-Prot Q64U20 (XYLA_BACFR)

Last modified November 3, 2009. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Xylose isomerase
    EC=5.3.1.5
Gene names
Name: xylA
Ordered Locus Names: BF2262
OrganismBacteroides fragilis [Complete proteome] [HAMAP]
Taxonomic identifier817 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

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Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the xylose isomerase family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Xylose isomerase HAMAP MF_00455
PRO_0000236956

Sites

Active site1031 By similarity
Active site1061 By similarity
Metal binding2341Magnesium 1 By similarity
Metal binding2701Magnesium 1 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2731Magnesium 2 By similarity
Metal binding2981Magnesium 1 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3111Magnesium 2 By similarity
Metal binding3411Magnesium 1 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q64U20-1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: D4811FE9E735DF6E

FASTA43949,015
        10         20         30         40         50         60 
MATKEYFPGI GKIKFEGKDS KNPMAFRYYD AEKMINGRSM KDWLKFAMAW WHTLCAEGGD 

        70         80         90        100        110        120 
QFGGGTKQFP WNGDPDPVQA AKNKMDAGFE FMQKMGIGYY CFHDVDLVTE ADSIEAYEAN 

       130        140        150        160        170        180 
LKELVAYAKQ KQAETGIKLL WGTANVFSHA RYMNGAATNP DFDVVARAAV QIKNAIDATI 

       190        200        210        220        230        240 
ELGGTNYVFW GGREGYMSLL NTDQKREKEH LAQMLTIARD YGRARGFKGT FLIEPKPMEP 

       250        260        270        280        290        300 
TKHQYDVDTE TVIGFLKAHG LDQDFKVNIE VNHATLAGHT FEHELAVAVD NGMLGSIDAN 

       310        320        330        340        350        360 
RGDYQNGWDT DQFPIDNFEL TQAMMQIIRN DGLGNGGTNF DAKTRRNSTD PEDIFIAHIA 

       370        380        390        400        410        420 
GMDAMARALE SAANLLNESP YQKMLSDRYA SFDAGKGKEF EEGKLSLEEL VAYAKANGEP 

       430 
KQTSGQQELY EALVNIYSL

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References

[1]"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YCH46.

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Cross-references

Sequence databases

AP006841 Genomic DNA. Translation: BAD49009.1.
RefSeqYP_099543.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3084044.
GenomeReviewsGene locus BF2262 in contig AP006841_GR.
KEGGbfr:BF2262.
NMPDRfig|295405.3.peg.1980.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ64U20.
OMAQFLIEPK.

Enzyme and pathway databases

BioCycBFRA295405:BF2262-MON.
BRENDA5.3.1.5. 868.

Family and domain databases

HAMAPMF_00455.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
IPR018115. Xylose_isomerase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameXYLA_BACFR
AccessionPrimary (citable) accession number: Q64U20
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2004
Last modified: November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents