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Q64ST5

- Q64ST5_BACFR

UniProt

Q64ST5 - Q64ST5_BACFR

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

BF2694

Organism
Bacteroides fragilis (strain YCH46)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

    Cofactori

    Binds 2 iron ions per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    DNA replicationUniRule annotation

    Keywords - Ligandi

    IronUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit betaUniRule annotation (EC:1.17.4.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:BF2694Imported
    OrganismiBacteroides fragilis (strain YCH46)Imported
    Taxonomic identifieri295405 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002197: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi295405.BF2694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64ST5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

    Phylogenomic databases

    KOiK00526.
    OMAiNIKDFAF.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64ST5-1 [UniParc]FASTAAdd to Basket

    « Hide

    METKKLKKNA LFNPEGDTET RLRKMIGGNT TNLNDFNNMR YKWVSDWYRQ    50
    GMNNFWIPEE INLTQDTKDY PHLTPAERTA YDKILSFLVF LDSLQSNNLP 100
    TLSEYITANE VNLCLHIQAF QECVHSQSYS YMLDSICSPE ERNDILYQWK 150
    TDEHLLRRNT FIGNCYNEFQ ENRDGFALMK TLIANYILEG IYFYSGFMFF 200
    YNLSRNGKMS GSAQEIRYIN RDENTHLWLF RNIILELKKE EPELFTPDKV 250
    KVYEEMMREG VKQEIAWGQY VIGDQIQGLN RQMISDYIHF LGNLRWSSLG 300
    YTPLYEDNRK EPESMHWVSQ YSNANMVKTD FFEAKSTAYA KSTALEDDL 349
    Length:349
    Mass (Da):41,318
    Last modified:October 25, 2004 - v1
    Checksum:i397DC8C148113650
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD49444.1.
    RefSeqiWP_011202979.1. NC_006347.1.
    YP_099978.1. NC_006347.1.

    Genome annotation databases

    EnsemblBacteriaiBAD49444; BAD49444; BF2694.
    GeneIDi3083574.
    KEGGibfr:BF2694.
    PATRICi21051019. VBIBacFra17906_2606.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD49444.1 .
    RefSeqi WP_011202979.1. NC_006347.1.
    YP_099978.1. NC_006347.1.

    3D structure databases

    ProteinModelPortali Q64ST5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295405.BF2694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD49444 ; BAD49444 ; BF2694 .
    GeneIDi 3083574.
    KEGGi bfr:BF2694.
    PATRICi 21051019. VBIBacFra17906_2606.

    Phylogenomic databases

    KOi K00526.
    OMAi NIKDFAF.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
      Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YCH46Imported.

    Entry informationi

    Entry nameiQ64ST5_BACFR
    AccessioniPrimary (citable) accession number: Q64ST5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3