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Q64ST5

- Q64ST5_BACFR

UniProt

Q64ST5 - Q64ST5_BACFR

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

BF2694

Organism
Bacteroides fragilis (strain YCH46)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Binds 2 iron ions per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

IronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit betaUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Ordered Locus Names:BF2694Imported
OrganismiBacteroides fragilis (strain YCH46)Imported
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi295405.BF2694.

Structurei

3D structure databases

ProteinModelPortaliQ64ST5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Phylogenomic databases

KOiK00526.
OMAiNIKDFAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64ST5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METKKLKKNA LFNPEGDTET RLRKMIGGNT TNLNDFNNMR YKWVSDWYRQ
60 70 80 90 100
GMNNFWIPEE INLTQDTKDY PHLTPAERTA YDKILSFLVF LDSLQSNNLP
110 120 130 140 150
TLSEYITANE VNLCLHIQAF QECVHSQSYS YMLDSICSPE ERNDILYQWK
160 170 180 190 200
TDEHLLRRNT FIGNCYNEFQ ENRDGFALMK TLIANYILEG IYFYSGFMFF
210 220 230 240 250
YNLSRNGKMS GSAQEIRYIN RDENTHLWLF RNIILELKKE EPELFTPDKV
260 270 280 290 300
KVYEEMMREG VKQEIAWGQY VIGDQIQGLN RQMISDYIHF LGNLRWSSLG
310 320 330 340
YTPLYEDNRK EPESMHWVSQ YSNANMVKTD FFEAKSTAYA KSTALEDDL
Length:349
Mass (Da):41,318
Last modified:October 25, 2004 - v1
Checksum:i397DC8C148113650
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD49444.1.
RefSeqiWP_011202979.1. NC_006347.1.
YP_099978.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD49444; BAD49444; BF2694.
GeneIDi3083574.
KEGGibfr:BF2694.
PATRICi21051019. VBIBacFra17906_2606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD49444.1 .
RefSeqi WP_011202979.1. NC_006347.1.
YP_099978.1. NC_006347.1.

3D structure databases

ProteinModelPortali Q64ST5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295405.BF2694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD49444 ; BAD49444 ; BF2694 .
GeneIDi 3083574.
KEGGi bfr:BF2694.
PATRICi 21051019. VBIBacFra17906_2606.

Phylogenomic databases

KOi K00526.
OMAi NIKDFAF.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46Imported.

Entry informationi

Entry nameiQ64ST5_BACFR
AccessioniPrimary (citable) accession number: Q64ST5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3