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Q64ST5

- Q64ST5_BACFR

UniProt

Q64ST5 - Q64ST5_BACFR

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Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
BF2694
Organism
Bacteroides fragilis (strain YCH46)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Binds 2 iron ions per subunit By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  3. deoxyribonucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

IronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit betaUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Ordered Locus Names:BF2694Imported
OrganismiBacteroides fragilis (strain YCH46)Imported
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi295405.BF2694.

Structurei

3D structure databases

ProteinModelPortaliQ64ST5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00526.
OMAiNIKDFAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64ST5-1 [UniParc]FASTAAdd to Basket

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METKKLKKNA LFNPEGDTET RLRKMIGGNT TNLNDFNNMR YKWVSDWYRQ    50
GMNNFWIPEE INLTQDTKDY PHLTPAERTA YDKILSFLVF LDSLQSNNLP 100
TLSEYITANE VNLCLHIQAF QECVHSQSYS YMLDSICSPE ERNDILYQWK 150
TDEHLLRRNT FIGNCYNEFQ ENRDGFALMK TLIANYILEG IYFYSGFMFF 200
YNLSRNGKMS GSAQEIRYIN RDENTHLWLF RNIILELKKE EPELFTPDKV 250
KVYEEMMREG VKQEIAWGQY VIGDQIQGLN RQMISDYIHF LGNLRWSSLG 300
YTPLYEDNRK EPESMHWVSQ YSNANMVKTD FFEAKSTAYA KSTALEDDL 349
Length:349
Mass (Da):41,318
Last modified:October 25, 2004 - v1
Checksum:i397DC8C148113650
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD49444.1.
RefSeqiWP_011202979.1. NC_006347.1.
YP_099978.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD49444; BAD49444; BF2694.
GeneIDi3083574.
KEGGibfr:BF2694.
PATRICi21051019. VBIBacFra17906_2606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD49444.1 .
RefSeqi WP_011202979.1. NC_006347.1.
YP_099978.1. NC_006347.1.

3D structure databases

ProteinModelPortali Q64ST5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295405.BF2694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD49444 ; BAD49444 ; BF2694 .
GeneIDi 3083574.
KEGGi bfr:BF2694.
PATRICi 21051019. VBIBacFra17906_2606.

Phylogenomic databases

KOi K00526.
OMAi NIKDFAF.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46Imported.

Entry informationi

Entry nameiQ64ST5_BACFR
AccessioniPrimary (citable) accession number: Q64ST5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi