Reviewed, UniProtKB/Swiss-Prot Q64PP7 (AROC_BACFR)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BF3792

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Chorismate synthase HAMAP MF_00300		PRO_0000140547

Sequences

	Sequence		Length	Mass (Da)
	Q64PP7-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 682C796A44923EE4	FASTA	358	39,261
	10 20 30 40 50 60 MFNSFGNIFR LTSFGESHGK GIGGVIDGFP AGIVIDEEFV QQELNRRRPG QSVITTSRKE 70 80 90 100 110 120 ADKVEFLSGI FEGKSTGCPI GFIVWNENQH SNDYNNLEKV YRPSHADYTY TVKYGIRDHR 130 140 150 160 170 180 GGGRSSARET ISRVVGGALA KLALRQLGIH ITAYTSQVGP IKLEGNYTDY DLDLIETNPV 190 200 210 220 230 240 RCPDPEKAKE MQDLIYKIKG EGDTIGGVLT CVIKGCPIGL GQPVYGKLHA ALGNAMLSIN 250 260 270 280 290 300 AAKAFEYGDG FKGLKQKGSE QNDVFYNNNG RIETRTNHSG GIQGGISNGQ DIFFRVAFKP 310 320 330 340 350 VATVLMEQET VNIDGIDTTL KARGRHDPCV LPRAVPIVEA MAAMTILDYY LLDRMTQL

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006841 Genomic DNA. Translation: BAD50534.1.
RefSeq	YP_101068.1.
3D structure databases
SMR	Q64PP7. Positions 2-354.
ModBase	Search...
Genome annotation databases
GeneID	3084873.
GenomeReviews	Gene locus BF3792 in contig AP006841_GR.
KEGG	bfr:BF3792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
Enzyme and pathway databases
BioCyc	BFRA295405:BF3792-MONOMER.
BRENDA	4.2.3.5. 868.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACFR

Accession

Primary (citable) accession number: Q64PP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 25, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)