Q64PM7 (G6PI_BACFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BF3812

Organism

Bacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]

Taxonomic identifier

295405 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180595
Sites
	Active site	287	1	Proton donor By similarity
	Active site	308	1	By similarity
	Active site	422	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64PM7 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: D2112CB217B7C65C	FASTA	445	48,750
	10 20 30 40 50 60 MISLNIEKTF GFISKESVSA YEAQVKAAQE ALENGTGKGN DFLGWLHLPS SISKEHLADL 70 80 90 100 110 120 KATAQVLRDN CEVVIVAGIG GSYLGARAVI EALSNSFTWL QEKKTAPVMI YAGHNIGEDY 130 140 150 160 170 180 LYELTEFLKD KKFGVINISK SGTTTETALA FRLLKKQCED QRGKEMAKKV IVAVTDAKKG 190 200 210 220 230 240 AARVTADKEG YKSFIIPDNV GGRFSVLTPV GLLPIAVAGF DIEQLVNGAA DMEKACGADV 250 260 270 280 290 300 PFAENPAAIY AATRNELYKN GKKIEILVNF CPKLHYVSEW WKQLYGESEG KDNKGIFPAA 310 320 330 340 350 360 VDFSTDLHSM GQWIQEGERT IFETVISVDK VNHKLEVPSD EANLDGLNFL AGKRVDEVNK 370 380 390 400 410 420 MAELGTQLAH VDGGVPNMRI VIPELSEFSI GQLLYFFEKA CGISGYLLGV NPFNQPGVEA 430 440 YKKNMFALLN KPGYEEESKA IQARL

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006841 Genomic DNA. Translation: BAD50554.1.
RefSeq	YP_101088.1. NC_006347.1.
3D structure databases
ProteinModelPortal	Q64PM7.
SMR	Q64PM7. Positions 2-445.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3084893.
GenomeReviews	Gene locus BF3812 in contig AP006841_GR.
KEGG	bfr:BF3812.
PATRIC	21053164. VBIBacFra17906_3660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	BFRA295405:BF3812-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACFR

Accession

Primary (citable) accession number: Q64PM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program