Q64PL4 (DNAA_BACFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	BF3825

Organism

Bacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]

Taxonomic identifier

295405 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114128
Regions
	Nucleotide binding	173 – 180	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q64PL4 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: FDE3BB56280B973C	FASTA	476	54,183
	10 20 30 40 50 60 MSESSHVGLW NRCLEIIRDN VPESTYKTWF VPIVPLKYED KTLIVQVPSQ FFYEFLEDKF 70 80 90 100 110 120 VDLLRKTLYK VIGDGTKLMY NVLVDKSSGA TVNQESTTRS TAIPQSGLPR VDERKAPGLL 130 140 150 160 170 180 RAPAVQDLDP HLNPNYNFET FIEGYSNKLS RSVAEAVAEN PAKTVFNPLF LHGASGVGKT 190 200 210 220 230 240 HLANAIGTRI KELYPDKRVL YVSAHLFQVQ YTDSVRNNTT NDFINFYQTI DVLIIDDIQE 250 260 270 280 290 300 FAGVTKTQNT FFHIFNHLHQ NGKQLILTSD RAPVLLQGME ERLLTRFKWG MVAELEKPTV 310 320 330 340 350 360 ELRKNILRNK IHRDGLQFPS EVIDYIAENV NESVRDLEGI VISIMAHSTI YNKEIDLDLA 370 380 390 400 410 420 QRIVRKVVRC ETKAVTIDDI INVVCKHFDL ESSAIHTKSR KREVVQARQV AMYLAKTHTD 430 440 450 460 470 FSTSKIGKFI GNKDHATVLH ACKTVKGQCE VDKGFRSDLE NIETLLKKRN VSNGER

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006841 Genomic DNA. Translation: BAD50567.1.
RefSeq	YP_101101.1. NC_006347.1.
3D structure databases
ProteinModelPortal	Q64PL4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3084906.
GenomeReviews	Gene locus BF3825 in contig AP006841_GR.
KEGG	bfr:BF3825.
PATRIC	21053192. VBIBacFra17906_3673.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q64PL4.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	BFRA295405:BF3825-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_BACFR

Accession

Primary (citable) accession number: Q64PL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program