Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q64P72

- NADK_BACFR

UniProt

Q64P72 - NADK_BACFR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptorUniRule annotation
Binding sitei77 – 771NADUniRule annotation
Binding sitei175 – 1751NADUniRule annotation
Binding sitei210 – 2101NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NADUniRule annotation
Nucleotide bindingi145 – 1462NADUniRule annotation
Nucleotide bindingi186 – 1916NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BF3968
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290NAD kinasePRO_0000229608Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295405.BF3968.

Structurei

3D structure databases

ProteinModelPortaliQ64P72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiNOG148743.
KOiK00858.
OMAiSAYRADG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64P72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFAIFGNTY QAKKSSHAAT LFKLLEKHGA EICVCREFHR FLKSDLKLNV
60 70 80 90 100
KADDLFDENN FDADMVISIG GDGTFLKAAR RVGNKGIPIL GINTGRLGFL
110 120 130 140 150
ADVSPEEMEE TIEEVYQNHY TVEERSVLQL LCDDKHLQNS PYALNEIAIL
160 170 180 190 200
KRDSSSMISI RTAINGAHLT TYQADGLIIA TPTGSTAYSL SVGGPIIVPH
210 220 230 240 250
SKTIAITPVA PHSLNVRPIV ICDDWEITLD VESRSHNFLV AIDGSSETCK
260 270 280 290
ETTRLTIRRA DYSIKVVKRF YHIFFDTLRT KMMWGADSRV
Length:290
Mass (Da):32,355
Last modified:October 25, 2004 - v1
Checksum:iC3448F310C87837C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD50710.1.
RefSeqiYP_101244.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD50710; BAD50710; BF3968.
GeneIDi3085049.
KEGGibfr:BF3968.
PATRICi21053474. VBIBacFra17906_3814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD50710.1 .
RefSeqi YP_101244.1. NC_006347.1.

3D structure databases

ProteinModelPortali Q64P72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295405.BF3968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD50710 ; BAD50710 ; BF3968 .
GeneIDi 3085049.
KEGGi bfr:BF3968.
PATRICi 21053474. VBIBacFra17906_3814.

Phylogenomic databases

eggNOGi NOG148743.
KOi K00858.
OMAi SAYRADG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46.

Entry informationi

Entry nameiNADK_BACFR
AccessioniPrimary (citable) accession number: Q64P72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3