Q64NL3 (RL22_BACFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L22

Gene names

Name:	rplV
Ordered Locus Names:	BF4176

Organism

Bacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]

Taxonomic identifier

295405 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides › Bacteroides fragilis

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01331 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome By similarity. HAMAP-Rule MF_01331
Subunit structure	Part of the 50S ribosomal subunit By similarity. HAMAP-Rule MF_01331
Sequence similarities	Belongs to the ribosomal protein L22P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 136	136	50S ribosomal protein L22 HAMAP-Rule MF_01331		PRO_0000243121

Sequences

	Sequence		Length	Mass (Da)
	Q64NL3 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 529AD65DFA5E31A9	FASTA	136	15,480
	10 20 30 40 50 60 MGARKKISAE KRKEALKTMY FAKLQNVPTS PRKMRLVADM IRGMEVNRAL GVLKFSSKEA 70 80 90 100 110 120 AARVEKLLRS AIANWEQKNE RKAESGELFV TKIFVDGGAT LKRMRPAPQG RGYRIRKRSN 130 HVTLFVDSKS NNEDQN

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006841 Genomic DNA. Translation: BAD50919.1.
RefSeq	YP_101453.1. NC_006347.1.
3D structure databases
ProteinModelPortal	Q64NL3.
ModBase	Search...
Protein-protein interaction databases
STRING	295405.BF4176.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD50919; BAD50919; BF4176.
GeneID	3085258.
KEGG	bfr:BF4176.
PATRIC	21053944. VBIBacFra17906_4030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0091.
KO	K02890.
OMA	ASRINKR.
ProtClustDB	PRK00565.
Family and domain databases
Gene3D	3.90.470.10. 1 hit.
HAMAP	MF_01331_B. Ribosomal_L22_B.
InterPro	IPR001063. Ribosomal_L22. IPR005727. Ribosomal_L22_bac/chlpt-type. [Graphical view]
PANTHER	PTHR13501. PTHR13501. 1 hit.
Pfam	PF00237. Ribosomal_L22. 1 hit. [Graphical view]
SUPFAM	SSF54843. Ribosomal_L22. 1 hit.
TIGRFAMs	TIGR01044. rplV_bact. 1 hit.
PROSITE	PS00464. RIBOSOMAL_L22. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL22_BACFR

Accession

Primary (citable) accession number: Q64NL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program