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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76Substrate1
Binding sitei151Substrate1
Binding sitei212Substrate1
Binding sitei242Substrate1
Binding sitei246Substrate1
Binding sitei247NAD1
Binding sitei299NAD1
Binding sitei334NAD1
Binding sitei403NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 215NAD3
Nucleotide bindingi276 – 281NAD6
Nucleotide bindingi355 – 357NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:BF4468
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169421 – 487AdenosylhomocysteinaseAdd BLAST487

Proteomic databases

PRIDEiQ64MT2.

Structurei

3D structure databases

ProteinModelPortaliQ64MT2.
SMRiQ64MT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64MT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYLCTTLYF KQFTFMSTEL FSTLPYKVAD ITLADFGRKE IDLAEKEMPG
60 70 80 90 100
LMALREKYGE SKPLKGARIM GSLHMTIQTA VLIETLVALG AEVRWCSCNI
110 120 130 140 150
YSTQDHAAAA IAASGVAVFA WKGETLADYW WCTLQALNFE GGKGPTVIVD
160 170 180 190 200
DGGDATMMIH VGYEAENNAA VLDKEVHAED EIELNAILKK VLAEDKERWH
210 220 230 240 250
RVAAEVRGVS EETTTGVHRL YQMQEEGKLL FPAFNVNDSV TKSKFDNLYG
260 270 280 290 300
CRESLADGIK RATDVMIAGK VVVVCGYGDV GKGCSHSMRS YGARVLVTEV
310 320 330 340 350
DPICALQAAM EGFEVVTMED ACKEGNIFVT TTGNIDIIRI DHMEQMKDQA
360 370 380 390 400
IVCNIGHFDN EIQVDALKHY PGIKRVNIKP QVDRYYFPDG HSIILLADGR
410 420 430 440 450
LVNLGCATGH PSFVMSNSFT NQTLAQIELF NKKYDINVYR LPKHLDEEVA
460 470 480
RLHLEKIGVK LTKLTPEQAA YIGVSVDGPY KADHYRY
Length:487
Mass (Da):54,186
Last modified:October 25, 2004 - v1
Checksum:i64AA176C52CF0B00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD51205.1.
RefSeqiWP_008770078.1. NC_006347.1.
YP_101739.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD51205; BAD51205; BF4468.
GeneIDi3085544.
KEGGibfr:BF4468.
PATRICifig|295405.11.peg.4306.

Similar proteinsi

Entry informationi

Entry nameiSAHH_BACFR
AccessioniPrimary (citable) accession number: Q64MT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families