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Q64MG4

- SYL_BACFR

UniProt

Q64MG4 - SYL_BACFR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei720 – 7201ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BF4586
    OrganismiBacteroides fragilis (strain YCH46)
    Taxonomic identifieri295405 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002197: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943Leucine--tRNA ligasePRO_0000151968Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi295405.BF4586.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64MG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi717 – 7215"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64MG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFREIEK KWQKIWVDNH TYQVNEDASK QKFYVLNMFP YPSGAGLHVG    50
    HPLGYIASDI YARYKRLQGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT 100
    VNNINRYREQ LDKIGFSFDW NREIRTCDPE YYHWTQWAFI KMFNSYYCND 150
    EKQARPIEEL IEAFSTNGTQ GMNVACGEEM DFTADEWNAK SEKEQQEILM 200
    NYRIAYLGNT MVNWCPALGT VLANDEVVDG VSERGGYPVI QKVMRQWCLR 250
    VSAYAQRLLD GLETVEWTDS LKETQRNWIG RSEGAEMNFK VKDSDIEFTI 300
    FTTRADTVFG VTFMVLAPES ELVAKLTTPE QKAEVDAYLD RTKKRTERER 350
    IADRSVSGVF SGSYAINPLT NEPIPVWISD YVLAGYGTGA IMAVPAHDSR 400
    DYAFAKHFNL EIRPLIEGCD VSEESFDAKE GIMMNSPRPG APEGGLVLNG 450
    LTVKEAIAKT KEYIKATGLG RVKVNFRLRD AIFSRQRYWG EPFPVYYKDG 500
    MPYMIDESCL PLELPEVAKF LPTETGEPPL GHATKWAWDT VNKCVTDNEN 550
    IDNRTIFPLE LNTMPGFAGS SAYYLRYMDP RNHEALVSPA VDQYWKNVDL 600
    YVGGTEHATG HLIYSRFWNK FLHDWGISVA EEPFQKLVNQ GMIQGRSNFV 650
    YRIKDTNTFV SLNLKDQYEV TPIHVDVNIV SNDILDLEAF KAWRPEYETA 700
    EFILEDGKYI CGWAVEKMSK SMFNVVNPDM IVEKYGADTL RMYEMFLGPV 750
    EQSKPWDTNG IDGVHRFIKK FWSLFYDRNG EYLVKDEPAT KEELKALHKL 800
    IKKVTGDIEQ FSYNTSVSAF MICVNELSSL KCNKKEVLEQ LIVVLAPFAP 850
    HVCEELWDTL GNTTSVCDAQ WPTFNEQYLV EDTVNYTISF NGKARFNMEF 900
    PADAASDAIQ ATVLADERSL KWTEGKTPKK VIVVPKKIVN IVI 943
    Length:943
    Mass (Da):107,969
    Last modified:October 25, 2004 - v1
    Checksum:i9F9A3355FAA30082
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD51323.1.
    RefSeqiWP_011203753.1. NC_006347.1.
    YP_101857.1. NC_006347.1.

    Genome annotation databases

    EnsemblBacteriaiBAD51323; BAD51323; BF4586.
    GeneIDi3085662.
    KEGGibfr:BF4586.
    PATRICi21054733. VBIBacFra17906_4410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD51323.1 .
    RefSeqi WP_011203753.1. NC_006347.1.
    YP_101857.1. NC_006347.1.

    3D structure databases

    ProteinModelPortali Q64MG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295405.BF4586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD51323 ; BAD51323 ; BF4586 .
    GeneIDi 3085662.
    KEGGi bfr:BF4586.
    PATRICi 21054733. VBIBacFra17906_4410.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
      Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YCH46.

    Entry informationi

    Entry nameiSYL_BACFR
    AccessioniPrimary (citable) accession number: Q64MG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3