Reviewed, UniProtKB/Swiss-Prot Q64MG2 (NTPA_BACFR)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BF4588

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Nucleoside-triphosphatase		PRO_0000178123

Sequences

	Sequence		Length	Mass (Da)
	Q64MG2-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: B7DC34C6EDC4FA40	FASTA	194	21,620
	10 20 30 40 50 60 MKRKLVFATN NAHKLEEVSA ILGDKVELLS LNDINCHTDI PETAETLEGN AYLKSSFIYR 70 80 90 100 110 120 NYGLNCFADD TGLEVESLGG APGVYSARYA GGEGHNAEAN MLKLLHELEG KDNRRAQFRT 130 140 150 160 170 180 AISLILDEKE YLFEGIIKGE IIKEKRGDSG FGYDPVFVPE GYDRTFAELG NEIKNQISHR 190 ALAVNKLCEF LRSI

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD51325.1.
RefSeq	YP_101859.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3085664.
GenomeReviews	Gene locus BF4588 in contig AP006841_GR.
KEGG	bfr:BF4588.
NMPDR	fig|295405.3.peg.4576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q64MG2.
Enzyme and pathway databases
BioCyc	BFRA295405:BF4588-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BACFR

Accession

Primary (citable) accession number: Q64MG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	October 25, 2004
Last modified:	October 14, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)