ID   PROF1_AMBAR             Reviewed;         131 AA.
AC   Q64LH1;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Profilin-1;
DE   AltName: Full=Pollen allergen Amb a 8;
DE   AltName: Allergen=Amb a 8;
GN   ORFNames=D106;
OS   Ambrosia artemisiifolia (Common ragweed).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Ambrosia.
OX   NCBI_TaxID=4212;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RX   PubMed=15237444; DOI=10.3748/wjg.v10.i14.2103;
RA   Tao A.L., He S.H.;
RT   "Bridging PCR and partially overlapping primers for novel allergen gene
RT   cloning and expression insert decoration.";
RL   World J. Gastroenterol. 10:2103-2108(2004).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY268426; AAP15202.1; -; mRNA.
DR   AlphaFoldDB; Q64LH1; -.
DR   SMR; Q64LH1; -.
DR   Allergome; 751; Amb a 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   Gene3D; 3.30.450.30; Dynein light chain 2a, cytoplasmic; 1.
DR   InterPro; IPR048278; PFN.
DR   InterPro; IPR005455; PFN_euk.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PROFILIN; 1.
DR   PANTHER; PTHR11604:SF73; PROFILIN; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; Profilin (actin-binding protein); 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199609"
SQ   SEQUENCE   131 AA;  14113 MW;  D0D33550C9618E50 CRC64;
     MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG VVWAQSATFP QVKPEEITGI MNDFNEPGSL
     APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTIKKTTMS LIIGIYDEPM TPGQCNMLVE
     RPGDYLLEQG F
//