Reviewed, UniProtKB/Swiss-Prot Q64LH1 (PROF1_AMBAR)

Names and origin

Protein names

Recommended name:
    Profilin-1
Alternative name(s):
    Pollen allergen Amb a 8
    Allergen=Amb a 8

Gene names

ORF Names:

D106

Organism

Ambrosia artemisiifolia (Short ragweed)

Taxonomic identifier

4212 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Ambrosia

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Profilin-1		PRO_0000199609

Sequences

	Sequence		Length	Mass (Da)
	Q64LH1-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: D0D33550C9618E50	FASTA	131	14,113
	10 20 30 40 50 60 MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG VVWAQSATFP QVKPEEITGI MNDFNEPGSL 70 80 90 100 110 120 APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTIKKTTMS LIIGIYDEPM TPGQCNMLVE 130 RPGDYLLEQG F

References

[1]	"Bridging PCR and partially overlapping primers for novel allergen gene cloning and expression insert decoration." Tao A.L., He S.H. World J. Gastroenterol. 10:2103-2108(2004) [PubMed: 15237444] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY268426 mRNA. Translation: AAP15202.1.
3D structure databases
SMR	Q64LH1. Positions 2-128.
ModBase	Search...
Family and domain databases
InterPro	IPR002097. Profilin. IPR005455. Profilin_plant. [Graphical view]
PANTHER	PTHR11604. Profilin_plant. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF1_AMBAR

Accession

Primary (citable) accession number: Q64LH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)