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Q64LH1

- PROF1_AMBAR

UniProt

Q64LH1 - PROF1_AMBAR

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Protein

Profilin-1

Gene
D106
Organism
Ambrosia artemisiifolia (Short ragweed)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Pollen allergen Amb a 8
Allergen: Amb a 8
Gene namesi
ORF Names:D106
OrganismiAmbrosia artemisiifolia (Short ragweed)
Taxonomic identifieri4212 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei751. Amb a 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 131130Profilin-1PRO_0000199609Add
BLAST

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structurei

3D structure databases

ProteinModelPortaliQ64LH1.
SMRiQ64LH1. Positions 2-131.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.

Family and domain databases

InterProiIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64LH1-1 [UniParc]FASTAAdd to Basket

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MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG VVWAQSATFP QVKPEEITGI    50
MNDFNEPGSL APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTIKKTTMS 100
LIIGIYDEPM TPGQCNMLVE RPGDYLLEQG F 131
Length:131
Mass (Da):14,113
Last modified:October 25, 2004 - v1
Checksum:iD0D33550C9618E50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268426 mRNA. Translation: AAP15202.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268426 mRNA. Translation: AAP15202.1 .

3D structure databases

ProteinModelPortali Q64LH1.
SMRi Q64LH1. Positions 2-131.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 751. Amb a 8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bridging PCR and partially overlapping primers for novel allergen gene cloning and expression insert decoration."
    Tao A.L., He S.H.
    World J. Gastroenterol. 10:2103-2108(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.

Entry informationi

Entry nameiPROF1_AMBAR
AccessioniPrimary (citable) accession number: Q64LH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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