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Q64LH1

- PROF1_AMBAR

UniProt

Q64LH1 - PROF1_AMBAR

Protein

Profilin-1

Gene

D106

Organism
Ambrosia artemisiifolia (Short ragweed)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-1
    Alternative name(s):
    Pollen allergen Amb a 8
    Allergen: Amb a 8
    Gene namesi
    ORF Names:D106
    OrganismiAmbrosia artemisiifolia (Short ragweed)
    Taxonomic identifieri4212 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei751. Amb a 8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 131130Profilin-1PRO_0000199609Add
    BLAST

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64LH1.
    SMRiQ64LH1. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64LH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG VVWAQSATFP QVKPEEITGI    50
    MNDFNEPGSL APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTIKKTTMS 100
    LIIGIYDEPM TPGQCNMLVE RPGDYLLEQG F 131
    Length:131
    Mass (Da):14,113
    Last modified:October 25, 2004 - v1
    Checksum:iD0D33550C9618E50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268426 mRNA. Translation: AAP15202.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268426 mRNA. Translation: AAP15202.1 .

    3D structure databases

    ProteinModelPortali Q64LH1.
    SMRi Q64LH1. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 751. Amb a 8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bridging PCR and partially overlapping primers for novel allergen gene cloning and expression insert decoration."
      Tao A.L., He S.H.
      World J. Gastroenterol. 10:2103-2108(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.

    Entry informationi

    Entry nameiPROF1_AMBAR
    AccessioniPrimary (citable) accession number: Q64LH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3