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Q64LH1 (PROF1_AMBAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin-1
Alternative name(s):
Pollen allergen Amb a 8
Allergen=Amb a 8
Gene names
ORF Names:D106
OrganismAmbrosia artemisiifolia (Short ragweed)
Taxonomic identifier4212 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the profilin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DiseaseAllergen
   LigandActin-binding
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 131130Profilin-1
PRO_0000199609

Sequences

Sequence LengthMass (Da)Tools
Q64LH1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: D0D33550C9618E50

FASTA13114,113
        10         20         30         40         50         60 
MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG VVWAQSATFP QVKPEEITGI MNDFNEPGSL 

        70         80         90        100        110        120 
APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTIKKTTMS LIIGIYDEPM TPGQCNMLVE 

       130 
RPGDYLLEQG F 

« Hide

References

[1]"Bridging PCR and partially overlapping primers for novel allergen gene cloning and expression insert decoration."
Tao A.L., He S.H.
World J. Gastroenterol. 10:2103-2108(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY268426 mRNA. Translation: AAP15202.1.

3D structure databases

ProteinModelPortalQ64LH1.
SMRQ64LH1. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome751. Amb a 8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROF1_AMBAR
AccessionPrimary (citable) accession number: Q64LH1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries