Q64LD2 (WDR25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 25

Gene names

Name:

WDR25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in heart, muscle, testis, ovary, uterus and prostate. Ref.1
Sequence similarities	Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q64LD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q64LD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: Missing.
     258-274: LSKSHMLLSTSMDKTFK → MPALCLVLCWFQGLLGE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 544	544	WD repeat-containing protein 25		PRO_0000256227
Regions
	Repeat	244 – 286	43	WD 1
	Repeat	290 – 329	40	WD 2
	Repeat	330 – 373	44	WD 3
	Repeat	375 – 420	46	WD 4
	Repeat	424 – 463	40	WD 5
	Repeat	469 – 510	42	WD 6
	Repeat	513 – 544	32	WD 7
Natural variations
	Alternative sequence	1 – 257	257	Missing in isoform 2.		VSP_021331
	Alternative sequence	258 – 274	17	LSKSH…DKTFK → MPALCLVLCWFQGLLGE in isoform 2.		VSP_021332
	Natural variant	59	1	K → R. Corresponds to variant rs2273801 [ dbSNP | Ensembl ].		VAR_060042
	Natural variant	88	1	W → R. Ref.1 Ref.2 Corresponds to variant rs2181170 [ dbSNP | Ensembl ].		VAR_028888
	Natural variant	119	1	T → M. Corresponds to variant rs34331240 [ dbSNP | Ensembl ].		VAR_060043
	Natural variant	149	1	H → R. Ref.2 Corresponds to variant rs2273800 [ dbSNP | Ensembl ].		VAR_028889
Experimental info
	Sequence conflict	30	1	F → L in BAF84649. Ref.2
	Sequence conflict	165	1	Q → R in BAF84649. Ref.2
	Sequence conflict	462	1	S → I in AAQ63174. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 3. Checksum: A4E67A5574F776BD	FASTA	544	60,161
	10 20 30 40 50 60 MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA 70 80 90 100 110 120 GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG KEPQVTFPIK EPSCSSLWTS 130 140 150 160 170 180 HVPASHMPLA AARFKQVKLS RNFPKSSFHA QSESETVGKN GSSFQKKKCE DCVVPYTPRR 190 200 210 220 230 240 LRQRQALSTE TGKGKDVEPQ GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF 250 260 270 280 290 300 HLRGHRGPVN TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW 310 320 330 340 350 360 APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL CGGFSSEMKA 370 380 390 400 410 420 WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR DSADRTIIAW DFRTSAKISN 430 440 450 460 470 480 QIFHERFTCP SLALHPREPV FLAQTNGNYL ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE 490 500 510 520 530 540 CSPGGDLLVT GSADGRVLMY SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM KIWH
	Isoform 2 [UniParc]. Checksum: 1132ED739A8EBB8B	FASTA	287	32,166
	10 20 30 40 50 60 MPALCLVLCW FQGLLGEVWN AVDSGHCLQT YSLHTEAVRA ARWAPCGRRI LSGGFDFALH 70 80 90 100 110 120 LTDLETGTQL FSGRSDFRIT TLKFHPKDHN IFLCGGFSSE MKAWDIRTGK VMRSYKATIQ 130 140 150 160 170 180 QTLDILFLRE GSEFLSSTDA STRDSADRTI IAWDFRTSAK ISNQIFHERF TCPSLALHPR 190 200 210 220 230 240 EPVFLAQTNG NYLALFSTVW PYRMSRRRRY EGHKVEGYSV GCECSPGGDL LVTGSADGRV 250 260 270 280 LMYSFRTASR ACTLQGHTQA CVGTTYHPVL PSVLATCSWG GDMKIWH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32." Jin F., Dai J., Ji C., Gu S., Wu M., Qian J., Xie Y., Mao Y. Biochem. Genet. 42:419-427(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ARG-88. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-88 AND ARG-149. Tissue: Neuroblastoma.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[5]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-275 (ISOFORM 1). Tissue: Neuroblastoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY295082 mRNA. Translation: AAQ63174.1. AK291960 mRNA. Translation: BAF84649.1. AL135838 Genomic DNA. No translation available. AL845552 Genomic DNA. No translation available. BC003641 mRNA. Translation: AAH03641.1. BX248767 mRNA. Translation: CAD66574.1.
IPI	IPI00465281. IPI00796363.
RefSeq	NP_001154948.1. NM_001161476.1. NP_078791.3. NM_024515.4.
UniGene	Hs.497600.
3D structure databases
ProteinModelPortal	Q64LD2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q64LD2. 1 interaction.
MINT	MINT-1464423.
STRING	9606.ENSP00000334148.
PTM databases
PhosphoSite	Q64LD2.
Polymorphism databases
DMDM	126302614.
Proteomic databases
PaxDb	Q64LD2.
PRIDE	Q64LD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335290; ENSP00000334148; ENSG00000176473. ENST00000402312; ENSP00000385540; ENSG00000176473. ENST00000542471; ENSP00000441903; ENSG00000176473. ENST00000554998; ENSP00000450661; ENSG00000176473.
GeneID	79446.
KEGG	hsa:79446.
UCSC	uc001yhn.3. human. uc001yho.3. human.
Organism-specific databases
CTD	79446.
GeneCards	GC14P101078.
HGNC	HGNC:21064. WDR25.
HPA	HPA003113.
neXtProt	NX_Q64LD2.
PharmGKB	PA142670607.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000154846.
HOVERGEN	HBG094158.
InParanoid	Q64LD2.
OMA	YSVGCEC.
OrthoDB	EOG4H19WH.
Gene expression databases
ArrayExpress	Q64LD2.
Bgee	Q64LD2.
CleanEx	HS_WDR25.
Genevestigator	Q64LD2.
GermOnline	ENSG00000176473. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79446.
NextBio	68413.

Entry information

Entry name

WDR25_HUMAN

Accession

Primary (citable) accession number: Q64LD2
Secondary accession number(s): A8K7E5 , Q6NVV6, Q86TQ4, Q9BTK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.