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Q64LD2 (WDR25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 25
Gene names
Name:WDR25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in heart, muscle, testis, ovary, uterus and prostate. Ref.1

Sequence similarities

Contains 7 WD repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q64LD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q64LD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: Missing.
     258-274: LSKSHMLLSTSMDKTFK → MPALCLVLCWFQGLLGE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 544544WD repeat-containing protein 25
PRO_0000256227

Regions

Repeat244 – 28643WD 1
Repeat290 – 32940WD 2
Repeat330 – 37344WD 3
Repeat375 – 42046WD 4
Repeat424 – 46340WD 5
Repeat469 – 51042WD 6
Repeat513 – 54432WD 7

Natural variations

Alternative sequence1 – 257257Missing in isoform 2.
VSP_021331
Alternative sequence258 – 27417LSKSH…DKTFK → MPALCLVLCWFQGLLGE in isoform 2.
VSP_021332
Natural variant591K → R.
Corresponds to variant rs2273801 [ dbSNP | Ensembl ].
VAR_060042
Natural variant881W → R. Ref.1 Ref.2
Corresponds to variant rs2181170 [ dbSNP | Ensembl ].
VAR_028888
Natural variant1191T → M.
Corresponds to variant rs34331240 [ dbSNP | Ensembl ].
VAR_060043
Natural variant1491H → R. Ref.2
Corresponds to variant rs2273800 [ dbSNP | Ensembl ].
VAR_028889

Experimental info

Sequence conflict301F → L in BAF84649. Ref.2
Sequence conflict1651Q → R in BAF84649. Ref.2
Sequence conflict4621S → I in AAQ63174. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: A4E67A5574F776BD

FASTA54460,161
        10         20         30         40         50         60 
MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA 

        70         80         90        100        110        120 
GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG KEPQVTFPIK EPSCSSLWTS 

       130        140        150        160        170        180 
HVPASHMPLA AARFKQVKLS RNFPKSSFHA QSESETVGKN GSSFQKKKCE DCVVPYTPRR 

       190        200        210        220        230        240 
LRQRQALSTE TGKGKDVEPQ GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF 

       250        260        270        280        290        300 
HLRGHRGPVN TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW 

       310        320        330        340        350        360 
APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL CGGFSSEMKA 

       370        380        390        400        410        420 
WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR DSADRTIIAW DFRTSAKISN 

       430        440        450        460        470        480 
QIFHERFTCP SLALHPREPV FLAQTNGNYL ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE 

       490        500        510        520        530        540 
CSPGGDLLVT GSADGRVLMY SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM 


KIWH 

« Hide

Isoform 2 [UniParc].

Checksum: 1132ED739A8EBB8B
Show »

FASTA28732,166

References

« Hide 'large scale' references
[1]"A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32."
Jin F., Dai J., Ji C., Gu S., Wu M., Qian J., Xie Y., Mao Y.
Biochem. Genet. 42:419-427(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ARG-88.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-88 AND ARG-149.
Tissue: Neuroblastoma.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.
[5]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-275 (ISOFORM 1).
Tissue: Neuroblastoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY295082 mRNA. Translation: AAQ63174.1.
AK291960 mRNA. Translation: BAF84649.1.
AL135838 Genomic DNA. No translation available.
AL845552 Genomic DNA. No translation available.
BC003641 mRNA. Translation: AAH03641.1.
BX248767 mRNA. Translation: CAD66574.1.
CCDSCCDS32157.1. [Q64LD2-1]
RefSeqNP_001154948.1. NM_001161476.1. [Q64LD2-1]
NP_078791.3. NM_024515.4. [Q64LD2-1]
XP_005268113.1. XM_005268056.2. [Q64LD2-1]
UniGeneHs.497600.

3D structure databases

ProteinModelPortalQ64LD2.
SMRQ64LD2. Positions 218-543.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122671. 1 interaction.
IntActQ64LD2. 1 interaction.
MINTMINT-1464423.
STRING9606.ENSP00000334148.

PTM databases

PhosphoSiteQ64LD2.

Polymorphism databases

DMDM126302614.

Proteomic databases

MaxQBQ64LD2.
PaxDbQ64LD2.
PRIDEQ64LD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335290; ENSP00000334148; ENSG00000176473. [Q64LD2-1]
ENST00000402312; ENSP00000385540; ENSG00000176473. [Q64LD2-1]
ENST00000542471; ENSP00000441903; ENSG00000176473. [Q64LD2-2]
ENST00000554998; ENSP00000450661; ENSG00000176473. [Q64LD2-1]
GeneID79446.
KEGGhsa:79446.
UCSCuc001yhn.3. human. [Q64LD2-1]
uc001yho.3. human. [Q64LD2-2]

Organism-specific databases

CTD79446.
GeneCardsGC14P101164.
HGNCHGNC:21064. WDR25.
HPAHPA003113.
neXtProtNX_Q64LD2.
PharmGKBPA142670607.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000154846.
HOVERGENHBG094158.
InParanoidQ64LD2.
OMAYSVGCEC.
OrthoDBEOG79W96M.
PhylomeDBQ64LD2.
TreeFamTF329325.

Enzyme and pathway databases

SignaLinkQ64LD2.

Gene expression databases

ArrayExpressQ64LD2.
BgeeQ64LD2.
CleanExHS_WDR25.
GenevestigatorQ64LD2.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 4 hits.
[Graphical view]
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79446.
NextBio68413.
PROQ64LD2.

Entry information

Entry nameWDR25_HUMAN
AccessionPrimary (citable) accession number: Q64LD2
Secondary accession number(s): A8K7E5 expand/collapse secondary AC list , Q6NVV6, Q86TQ4, Q9BTK5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM