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Q64LD2

- WDR25_HUMAN

UniProt

Q64LD2 - WDR25_HUMAN

Protein

WD repeat-containing protein 25

Gene

WDR25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ64LD2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 25
    Gene namesi
    Name:WDR25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:21064. WDR25.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670607.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 544544WD repeat-containing protein 25PRO_0000256227Add
    BLAST

    Proteomic databases

    MaxQBiQ64LD2.
    PaxDbiQ64LD2.
    PRIDEiQ64LD2.

    PTM databases

    PhosphoSiteiQ64LD2.

    Expressioni

    Tissue specificityi

    Expressed in heart, muscle, testis, ovary, uterus and prostate.1 Publication

    Gene expression databases

    ArrayExpressiQ64LD2.
    BgeeiQ64LD2.
    CleanExiHS_WDR25.
    GenevestigatoriQ64LD2.

    Organism-specific databases

    HPAiHPA003113.

    Interactioni

    Protein-protein interaction databases

    BioGridi122671. 1 interaction.
    IntActiQ64LD2. 1 interaction.
    MINTiMINT-1464423.
    STRINGi9606.ENSP00000334148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64LD2.
    SMRiQ64LD2. Positions 218-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati244 – 28643WD 1Add
    BLAST
    Repeati290 – 32940WD 2Add
    BLAST
    Repeati330 – 37344WD 3Add
    BLAST
    Repeati375 – 42046WD 4Add
    BLAST
    Repeati424 – 46340WD 5Add
    BLAST
    Repeati469 – 51042WD 6Add
    BLAST
    Repeati513 – 54432WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000154846.
    HOVERGENiHBG094158.
    InParanoidiQ64LD2.
    OMAiYSVGCEC.
    OrthoDBiEOG79W96M.
    PhylomeDBiQ64LD2.
    TreeFamiTF329325.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q64LD2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF    50
    ASGTLDVPKA GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG 100
    KEPQVTFPIK EPSCSSLWTS HVPASHMPLA AARFKQVKLS RNFPKSSFHA 150
    QSESETVGKN GSSFQKKKCE DCVVPYTPRR LRQRQALSTE TGKGKDVEPQ 200
    GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF HLRGHRGPVN 250
    TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW 300
    APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL 350
    CGGFSSEMKA WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR 400
    DSADRTIIAW DFRTSAKISN QIFHERFTCP SLALHPREPV FLAQTNGNYL 450
    ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE CSPGGDLLVT GSADGRVLMY 500
    SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM KIWH 544
    Length:544
    Mass (Da):60,161
    Last modified:February 20, 2007 - v3
    Checksum:iA4E67A5574F776BD
    GO
    Isoform 2 (identifier: Q64LD2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-257: Missing.
         258-274: LSKSHMLLSTSMDKTFK → MPALCLVLCWFQGLLGE

    Show »
    Length:287
    Mass (Da):32,166
    Checksum:i1132ED739A8EBB8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301F → L in BAF84649. (PubMed:14702039)Curated
    Sequence conflicti165 – 1651Q → R in BAF84649. (PubMed:14702039)Curated
    Sequence conflicti462 – 4621S → I in AAQ63174. (PubMed:15587985)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591K → R.
    Corresponds to variant rs2273801 [ dbSNP | Ensembl ].
    VAR_060042
    Natural varianti88 – 881W → R.2 Publications
    Corresponds to variant rs2181170 [ dbSNP | Ensembl ].
    VAR_028888
    Natural varianti119 – 1191T → M.
    Corresponds to variant rs34331240 [ dbSNP | Ensembl ].
    VAR_060043
    Natural varianti149 – 1491H → R.1 Publication
    Corresponds to variant rs2273800 [ dbSNP | Ensembl ].
    VAR_028889

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 257257Missing in isoform 2. 1 PublicationVSP_021331Add
    BLAST
    Alternative sequencei258 – 27417LSKSH…DKTFK → MPALCLVLCWFQGLLGE in isoform 2. 1 PublicationVSP_021332Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY295082 mRNA. Translation: AAQ63174.1.
    AK291960 mRNA. Translation: BAF84649.1.
    AL135838 Genomic DNA. No translation available.
    AL845552 Genomic DNA. No translation available.
    BC003641 mRNA. Translation: AAH03641.1.
    BX248767 mRNA. Translation: CAD66574.1.
    CCDSiCCDS32157.1. [Q64LD2-1]
    RefSeqiNP_001154948.1. NM_001161476.1. [Q64LD2-1]
    NP_078791.3. NM_024515.4. [Q64LD2-1]
    XP_005268113.1. XM_005268056.2. [Q64LD2-1]
    UniGeneiHs.497600.

    Genome annotation databases

    EnsembliENST00000335290; ENSP00000334148; ENSG00000176473. [Q64LD2-1]
    ENST00000402312; ENSP00000385540; ENSG00000176473. [Q64LD2-1]
    ENST00000542471; ENSP00000441903; ENSG00000176473. [Q64LD2-2]
    ENST00000554998; ENSP00000450661; ENSG00000176473. [Q64LD2-1]
    GeneIDi79446.
    KEGGihsa:79446.
    UCSCiuc001yhn.3. human. [Q64LD2-1]
    uc001yho.3. human. [Q64LD2-2]

    Polymorphism databases

    DMDMi126302614.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY295082 mRNA. Translation: AAQ63174.1 .
    AK291960 mRNA. Translation: BAF84649.1 .
    AL135838 Genomic DNA. No translation available.
    AL845552 Genomic DNA. No translation available.
    BC003641 mRNA. Translation: AAH03641.1 .
    BX248767 mRNA. Translation: CAD66574.1 .
    CCDSi CCDS32157.1. [Q64LD2-1 ]
    RefSeqi NP_001154948.1. NM_001161476.1. [Q64LD2-1 ]
    NP_078791.3. NM_024515.4. [Q64LD2-1 ]
    XP_005268113.1. XM_005268056.2. [Q64LD2-1 ]
    UniGenei Hs.497600.

    3D structure databases

    ProteinModelPortali Q64LD2.
    SMRi Q64LD2. Positions 218-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122671. 1 interaction.
    IntActi Q64LD2. 1 interaction.
    MINTi MINT-1464423.
    STRINGi 9606.ENSP00000334148.

    PTM databases

    PhosphoSitei Q64LD2.

    Polymorphism databases

    DMDMi 126302614.

    Proteomic databases

    MaxQBi Q64LD2.
    PaxDbi Q64LD2.
    PRIDEi Q64LD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335290 ; ENSP00000334148 ; ENSG00000176473 . [Q64LD2-1 ]
    ENST00000402312 ; ENSP00000385540 ; ENSG00000176473 . [Q64LD2-1 ]
    ENST00000542471 ; ENSP00000441903 ; ENSG00000176473 . [Q64LD2-2 ]
    ENST00000554998 ; ENSP00000450661 ; ENSG00000176473 . [Q64LD2-1 ]
    GeneIDi 79446.
    KEGGi hsa:79446.
    UCSCi uc001yhn.3. human. [Q64LD2-1 ]
    uc001yho.3. human. [Q64LD2-2 ]

    Organism-specific databases

    CTDi 79446.
    GeneCardsi GC14P101164.
    HGNCi HGNC:21064. WDR25.
    HPAi HPA003113.
    neXtProti NX_Q64LD2.
    PharmGKBi PA142670607.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000154846.
    HOVERGENi HBG094158.
    InParanoidi Q64LD2.
    OMAi YSVGCEC.
    OrthoDBi EOG79W96M.
    PhylomeDBi Q64LD2.
    TreeFami TF329325.

    Enzyme and pathway databases

    SignaLinki Q64LD2.

    Miscellaneous databases

    GenomeRNAii 79446.
    NextBioi 68413.
    PROi Q64LD2.

    Gene expression databases

    ArrayExpressi Q64LD2.
    Bgeei Q64LD2.
    CleanExi HS_WDR25.
    Genevestigatori Q64LD2.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32."
      Jin F., Dai J., Ji C., Gu S., Wu M., Qian J., Xie Y., Mao Y.
      Biochem. Genet. 42:419-427(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ARG-88.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-88 AND ARG-149.
      Tissue: Neuroblastoma.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    5. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-275 (ISOFORM 1).
      Tissue: Neuroblastoma.

    Entry informationi

    Entry nameiWDR25_HUMAN
    AccessioniPrimary (citable) accession number: Q64LD2
    Secondary accession number(s): A8K7E5
    , Q6NVV6, Q86TQ4, Q9BTK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3