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Protein

WD repeat-containing protein 25

Gene

WDR25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ64LD2.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 25
Gene namesi
Name:WDR25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:21064. WDR25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544WD repeat-containing protein 25PRO_0000256227Add
BLAST

Proteomic databases

MaxQBiQ64LD2.
PaxDbiQ64LD2.
PRIDEiQ64LD2.

PTM databases

PhosphoSiteiQ64LD2.

Expressioni

Tissue specificityi

Expressed in heart, muscle, testis, ovary, uterus and prostate.1 Publication

Gene expression databases

BgeeiQ64LD2.
CleanExiHS_WDR25.
ExpressionAtlasiQ64LD2. baseline and differential.
GenevestigatoriQ64LD2.

Organism-specific databases

HPAiHPA003113.

Interactioni

Protein-protein interaction databases

BioGridi122671. 7 interactions.
IntActiQ64LD2. 1 interaction.
MINTiMINT-1464423.
STRINGi9606.ENSP00000334148.

Structurei

3D structure databases

ProteinModelPortaliQ64LD2.
SMRiQ64LD2. Positions 240-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati244 – 28643WD 1Add
BLAST
Repeati290 – 32940WD 2Add
BLAST
Repeati330 – 37344WD 3Add
BLAST
Repeati375 – 42046WD 4Add
BLAST
Repeati424 – 46340WD 5Add
BLAST
Repeati469 – 51042WD 6Add
BLAST
Repeati513 – 54432WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000154846.
HOVERGENiHBG094158.
InParanoidiQ64LD2.
OMAiYSVGCEC.
OrthoDBiEOG79W96M.
PhylomeDBiQ64LD2.
TreeFamiTF329325.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q64LD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF
60 70 80 90 100
ASGTLDVPKA GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG
110 120 130 140 150
KEPQVTFPIK EPSCSSLWTS HVPASHMPLA AARFKQVKLS RNFPKSSFHA
160 170 180 190 200
QSESETVGKN GSSFQKKKCE DCVVPYTPRR LRQRQALSTE TGKGKDVEPQ
210 220 230 240 250
GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF HLRGHRGPVN
260 270 280 290 300
TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW
310 320 330 340 350
APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL
360 370 380 390 400
CGGFSSEMKA WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR
410 420 430 440 450
DSADRTIIAW DFRTSAKISN QIFHERFTCP SLALHPREPV FLAQTNGNYL
460 470 480 490 500
ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE CSPGGDLLVT GSADGRVLMY
510 520 530 540
SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM KIWH
Length:544
Mass (Da):60,161
Last modified:February 20, 2007 - v3
Checksum:iA4E67A5574F776BD
GO
Isoform 2 (identifier: Q64LD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: Missing.
     258-274: LSKSHMLLSTSMDKTFK → MPALCLVLCWFQGLLGE

Show »
Length:287
Mass (Da):32,166
Checksum:i1132ED739A8EBB8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301F → L in BAF84649 (PubMed:14702039).Curated
Sequence conflicti165 – 1651Q → R in BAF84649 (PubMed:14702039).Curated
Sequence conflicti462 – 4621S → I in AAQ63174 (PubMed:15587985).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591K → R.
Corresponds to variant rs2273801 [ dbSNP | Ensembl ].
VAR_060042
Natural varianti88 – 881W → R.2 Publications
Corresponds to variant rs2181170 [ dbSNP | Ensembl ].
VAR_028888
Natural varianti119 – 1191T → M.
Corresponds to variant rs34331240 [ dbSNP | Ensembl ].
VAR_060043
Natural varianti149 – 1491H → R.1 Publication
Corresponds to variant rs2273800 [ dbSNP | Ensembl ].
VAR_028889

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 257257Missing in isoform 2. 1 PublicationVSP_021331Add
BLAST
Alternative sequencei258 – 27417LSKSH…DKTFK → MPALCLVLCWFQGLLGE in isoform 2. 1 PublicationVSP_021332Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY295082 mRNA. Translation: AAQ63174.1.
AK291960 mRNA. Translation: BAF84649.1.
AL135838 Genomic DNA. No translation available.
AL845552 Genomic DNA. No translation available.
BC003641 mRNA. Translation: AAH03641.1.
BX248767 mRNA. Translation: CAD66574.1.
CCDSiCCDS32157.1. [Q64LD2-1]
RefSeqiNP_001154948.1. NM_001161476.1. [Q64LD2-1]
NP_078791.3. NM_024515.4. [Q64LD2-1]
XP_005268113.1. XM_005268056.2. [Q64LD2-1]
UniGeneiHs.497600.

Genome annotation databases

EnsembliENST00000335290; ENSP00000334148; ENSG00000176473. [Q64LD2-1]
ENST00000402312; ENSP00000385540; ENSG00000176473. [Q64LD2-1]
ENST00000542471; ENSP00000441903; ENSG00000176473. [Q64LD2-2]
ENST00000554998; ENSP00000450661; ENSG00000176473. [Q64LD2-1]
GeneIDi79446.
KEGGihsa:79446.
UCSCiuc001yhn.3. human. [Q64LD2-1]
uc001yho.3. human. [Q64LD2-2]

Polymorphism databases

DMDMi126302614.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY295082 mRNA. Translation: AAQ63174.1.
AK291960 mRNA. Translation: BAF84649.1.
AL135838 Genomic DNA. No translation available.
AL845552 Genomic DNA. No translation available.
BC003641 mRNA. Translation: AAH03641.1.
BX248767 mRNA. Translation: CAD66574.1.
CCDSiCCDS32157.1. [Q64LD2-1]
RefSeqiNP_001154948.1. NM_001161476.1. [Q64LD2-1]
NP_078791.3. NM_024515.4. [Q64LD2-1]
XP_005268113.1. XM_005268056.2. [Q64LD2-1]
UniGeneiHs.497600.

3D structure databases

ProteinModelPortaliQ64LD2.
SMRiQ64LD2. Positions 240-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122671. 7 interactions.
IntActiQ64LD2. 1 interaction.
MINTiMINT-1464423.
STRINGi9606.ENSP00000334148.

PTM databases

PhosphoSiteiQ64LD2.

Polymorphism databases

DMDMi126302614.

Proteomic databases

MaxQBiQ64LD2.
PaxDbiQ64LD2.
PRIDEiQ64LD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335290; ENSP00000334148; ENSG00000176473. [Q64LD2-1]
ENST00000402312; ENSP00000385540; ENSG00000176473. [Q64LD2-1]
ENST00000542471; ENSP00000441903; ENSG00000176473. [Q64LD2-2]
ENST00000554998; ENSP00000450661; ENSG00000176473. [Q64LD2-1]
GeneIDi79446.
KEGGihsa:79446.
UCSCiuc001yhn.3. human. [Q64LD2-1]
uc001yho.3. human. [Q64LD2-2]

Organism-specific databases

CTDi79446.
GeneCardsiGC14P101226.
HGNCiHGNC:21064. WDR25.
HPAiHPA003113.
neXtProtiNX_Q64LD2.
PharmGKBiPA142670607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000154846.
HOVERGENiHBG094158.
InParanoidiQ64LD2.
OMAiYSVGCEC.
OrthoDBiEOG79W96M.
PhylomeDBiQ64LD2.
TreeFamiTF329325.

Enzyme and pathway databases

SignaLinkiQ64LD2.

Miscellaneous databases

ChiTaRSiWDR25. human.
GenomeRNAii79446.
NextBioi68413.
PROiQ64LD2.

Gene expression databases

BgeeiQ64LD2.
CleanExiHS_WDR25.
ExpressionAtlasiQ64LD2. baseline and differential.
GenevestigatoriQ64LD2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32."
    Jin F., Dai J., Ji C., Gu S., Wu M., Qian J., Xie Y., Mao Y.
    Biochem. Genet. 42:419-427(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ARG-88.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-88 AND ARG-149.
    Tissue: Neuroblastoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-275 (ISOFORM 1).
    Tissue: Neuroblastoma.

Entry informationi

Entry nameiWDR25_HUMAN
AccessioniPrimary (citable) accession number: Q64LD2
Secondary accession number(s): A8K7E5
, Q6NVV6, Q86TQ4, Q9BTK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.