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Protein

RNA-binding protein 4B

Gene

Rbm4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 17718CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 4B
Alternative name(s):
RNA-binding motif protein 30
RNA-binding motif protein 4B
RNA-binding protein 30
Zinc-responsive protein ZD7
Gene namesi
Name:Rbm4b
Synonyms:Rbm30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359343. Rbm4b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357RNA-binding protein 4BPRO_0000081789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei302 – 3021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64LC9.
PRIDEiQ64LC9.

PTM databases

iPTMnetiQ64LC9.

Expressioni

Gene expression databases

GenevisibleiQ64LC9. RN.

Interactioni

Subunit structurei

Interacts with TNPO3, which may mediate nuclear import of the protein.By similarity

Protein-protein interaction databases

IntActiQ64LC9. 1 interaction.
STRINGi10116.ENSRNOP00000026605.

Structurei

3D structure databases

ProteinModelPortaliQ64LC9.
SMRiQ64LC9. Positions 1-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7271RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 14871RRM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 357162Interaction with TNPO3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi231 – 24010Poly-Ala
Compositional biasi286 – 2927Poly-Ala

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 17718CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0109. Eukaryota.
ENOG41105PP. LUCA.
GeneTreeiENSGT00390000020883.
HOGENOMiHOG000026790.
HOVERGENiHBG062217.
InParanoidiQ64LC9.
KOiK13187.
OMAiVYYNDAY.
OrthoDBiEOG7SFJ0M.
PhylomeDBiQ64LC9.
TreeFamiTF320661.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64LC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED
60 70 80 90 100
AIRNLHHYKL HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE
110 120 130 140 150
YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL
160 170 180 190 200
RTAPGMGDQS GCYRCGKEGH WSKECPVDRT GRVADFTEQY NEQYGAVRTP
210 220 230 240 250
YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA YNYAEQTMSH
260 270 280 290 300
LPQVQSSAVP SHLNSTSVDP YDRHLLQNSG SAATSAAMAA AASSSYYGRD
310 320 330 340 350
RSPLRRNAAV LPTVGEGYGY GPESEMSQAS AATRNSLYDM ARYEREQYVD

RARYSAF
Length:357
Mass (Da):39,991
Last modified:April 12, 2005 - v2
Checksum:i3BD8274D9261BC39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861F → L in AAQ73500 (PubMed:15361827).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303541 mRNA. Translation: AAQ73500.1.
BC086416 mRNA. Translation: AAH86416.1.
RefSeqiNP_001007015.2. NM_001007014.2.
XP_008758386.1. XM_008760164.1.
XP_008758387.1. XM_008760165.1.
XP_008758388.1. XM_008760166.1.
UniGeneiRn.203522.

Genome annotation databases

EnsembliENSRNOT00000084410; ENSRNOP00000071527; ENSRNOG00000061795.
GeneIDi474154.
KEGGirno:474154.
UCSCiRGD:1359343. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303541 mRNA. Translation: AAQ73500.1.
BC086416 mRNA. Translation: AAH86416.1.
RefSeqiNP_001007015.2. NM_001007014.2.
XP_008758386.1. XM_008760164.1.
XP_008758387.1. XM_008760165.1.
XP_008758388.1. XM_008760166.1.
UniGeneiRn.203522.

3D structure databases

ProteinModelPortaliQ64LC9.
SMRiQ64LC9. Positions 1-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64LC9. 1 interaction.
STRINGi10116.ENSRNOP00000026605.

PTM databases

iPTMnetiQ64LC9.

Proteomic databases

PaxDbiQ64LC9.
PRIDEiQ64LC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084410; ENSRNOP00000071527; ENSRNOG00000061795.
GeneIDi474154.
KEGGirno:474154.
UCSCiRGD:1359343. rat.

Organism-specific databases

CTDi83759.
RGDi1359343. Rbm4b.

Phylogenomic databases

eggNOGiKOG0109. Eukaryota.
ENOG41105PP. LUCA.
GeneTreeiENSGT00390000020883.
HOGENOMiHOG000026790.
HOVERGENiHBG062217.
InParanoidiQ64LC9.
KOiK13187.
OMAiVYYNDAY.
OrthoDBiEOG7SFJ0M.
PhylomeDBiQ64LC9.
TreeFamiTF320661.

Miscellaneous databases

PROiQ64LC9.

Gene expression databases

GenevisibleiQ64LC9. RN.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats."
    Ishii H., Vecchione A., Furukawa Y., Croce C.M., Huebner K., Fong L.Y.Y.
    Oncogene 23:8040-8048(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRBM4B_RAT
AccessioniPrimary (citable) accession number: Q64LC9
Secondary accession number(s): Q5U1X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.