Reviewed, UniProtKB/Swiss-Prot Q64I00 (DHE4_PONPY)

Names and origin

Protein names

Recommended name:
    Glutamate dehydrogenase 2, mitochondrial
      Short name=GDH
    EC=1.4.1.3

Gene names

Name:

GLUD2

Organism

Pongo pygmaeus (Bornean orangutan)

Taxonomic identifier

9600 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
Catalytic activity	L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
Subunit structure	Homohexamer By similarity.
Subcellular location	Mitochondrion matrixBy similarity.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 53	53	Mitochondrion By similarity
	Chain	54 – 558	505	Glutamate dehydrogenase 2, mitochondrial		PRO_0000007211
Sites
	Active site	183	1	By similarity
	Binding site	84	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64I00-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: EF26FEC7089E5D44	FASTA	558	61,386
	10 20 30 40 50 60 MYRYLGKALL LSRAGPAALG SAANHSAALL GRARGQPAAA SQPGLALASR RHYSELVADR 70 80 90 100 110 120 EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 130 140 150 160 170 180 PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 190 200 210 220 230 240 GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGID VPAPDMNTGE REMSWIADTY 250 260 270 280 290 300 ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SNVGMTPGFG 310 320 330 340 350 360 DKTFVVQGFG NVGLHSMRYL HRFGAKCVAV GESDGSIWNP DGIDPKELED FRLQHGSILG 370 380 390 400 410 420 FPKAKPYEGS ILEADCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 430 440 450 460 470 480 NILVIPDVYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 490 500 510 520 530 540 HGGTIPIVPT AEFRDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 550 NAIEKVFKVY SEAGVTFT

References

[1]	"Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux." Burki F., Kaessmann H. Nat. Genet. 36:1061-1063(2004) [PubMed: 15378063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY588268 Genomic DNA. Translation: AAU03134.1.
3D structure databases
SMR	Q64I00. Positions 58-558.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q64I00.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DHase. IPR006096. Glu/Leu/Phe/Val_DHase_C. IPR006097. Glu/Leu/Phe/Val_DHase_dimer. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11606:SF2. GLFV_DH. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PRINTS	PR00082. GLFDHDRGNASE.
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE4_PONPY

Accession

Primary (citable) accession number: Q64I00

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	October 25, 2004
Last modified:	November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)