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Q64HZ9 (DHE4_HYLLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate dehydrogenase 2, mitochondrial

Short name=GDH 2
EC=1.4.1.3
Gene names
Name:GLUD2
OrganismHylobates lar (Common gibbon) (White-handed gibbon)
Taxonomic identifier9580 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeHylobates

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

Catalytic activity

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Subunit structure

Homohexamer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Post-translational modification

Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
ADP-ribosylation
Phosphoprotein
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5050Mitochondrion By similarity
Chain51 – 555505Glutamate dehydrogenase 2, mitochondrial
PRO_0000007209

Sites

Active site1801 By similarity
Binding site811Substrate By similarity

Amino acid modifications

Modified residue651N6-succinyllysine By similarity
Modified residue761Phosphoserine By similarity
Modified residue811N6-acetyllysine; alternate By similarity
Modified residue811N6-succinyllysine; alternate By similarity
Modified residue1071N6-acetyllysine; alternate By similarity
Modified residue1071N6-succinyllysine; alternate By similarity
Modified residue1251Phosphoserine By similarity
Modified residue1321Phosphotyrosine By similarity
Modified residue1591N6-acetyllysine; alternate By similarity
Modified residue1591N6-succinyllysine; alternate By similarity
Modified residue1681N6-acetyllysine By similarity
Modified residue1691ADP-ribosylcysteine By similarity
Modified residue1801N6-acetyllysine; alternate By similarity
Modified residue1801N6-succinyllysine; alternate By similarity
Modified residue1841N6-acetyllysine By similarity
Modified residue1881N6-acetyllysine; alternate By similarity
Modified residue1881N6-succinyllysine; alternate By similarity
Modified residue1971N6-succinyllysine By similarity
Modified residue2081N6-acetyllysine By similarity
Modified residue3231N6-acetyllysine By similarity
Modified residue3431N6-acetyllysine; alternate By similarity
Modified residue3431N6-succinyllysine; alternate By similarity
Modified residue3491N6-acetyllysine; alternate By similarity
Modified residue3491N6-succinyllysine; alternate By similarity
Modified residue3601N6-acetyllysine; alternate By similarity
Modified residue3601N6-succinyllysine; alternate By similarity
Modified residue3621N6-acetyllysine; alternate By similarity
Modified residue3621N6-succinyllysine; alternate By similarity
Modified residue3831N6-acetyllysine By similarity
Modified residue3871N6-acetyllysine; alternate By similarity
Modified residue3871N6-succinyllysine; alternate By similarity
Modified residue3961N6-acetyllysine By similarity
Modified residue4121N6-acetyllysine; alternate By similarity
Modified residue4121N6-succinyllysine; alternate By similarity
Modified residue4541N6-acetyllysine; alternate By similarity
Modified residue4541N6-succinyllysine; alternate By similarity
Modified residue4741N6-acetyllysine; alternate By similarity
Modified residue4741N6-succinyllysine; alternate By similarity
Modified residue4771N6-acetyllysine; alternate By similarity
Modified residue4771N6-succinyllysine; alternate By similarity
Modified residue5001N6-acetyllysine; alternate By similarity
Modified residue5001N6-succinyllysine; alternate By similarity
Modified residue5241N6-acetyllysine; alternate By similarity
Modified residue5241N6-succinyllysine; alternate By similarity
Modified residue5421N6-acetyllysine; alternate By similarity
Modified residue5421N6-succinyllysine; alternate By similarity
Modified residue5451N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64HZ9 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 36BF0E321F993A53

FASTA55560,866
        10         20         30         40         50         60 
MYCYLGKALL PSGAGPAALG SAGAALLGRA RGQPAAAPQP GLALAAWRHY SEVVADRKDD 

        70         80         90        100        110        120 
PNFFKMVEGF FDRGASIVED KLVKDLRTRE SEEQKRNRVR GILRIIKPCN HVLSLSFPIR 

       130        140        150        160        170        180 
RDDGSWEVIE GYRAQHSQHR TPCKGGIRYS ADVSVDEVKA LASLMTYKCA VVDVPFGGAK 

       190        200        210        220        230        240 
AGVKINPKNY TENELEKITR RFTMELAKKG FIGPGIDVPA PDMNTGEREM SWIADTYAST 

       250        260        270        280        290        300 
IGHYDINAHA CVTGKPISQG GIHGRISATG RGVFHGIENF INEASYMSIL GMTPGFGDKT 

       310        320        330        340        350        360 
FVVQGFGNVG LHSMRYLHRF GAKCIAVGES DGSIWNPDGI DPKELEDFKL QHGSILGFPK 

       370        380        390        400        410        420 
AKPYEGSILE ADCDILIPAA SEKQLTKSNA PRVKAKIIAE GANGPTTPEA DKIFLERNIM 

       430        440        450        460        470        480 
VIPDLYVNAG GVTVSYFEWL KNLNHVSYGR LTFKYERDSN YHLLMSVQES LERKFGKHGG 

       490        500        510        520        530        540 
TIPIVPTAEF QDSISGASEK DIVHSALAYT MERSARQIMR TAMKYNLGLD LRTAAYVNAI 

       550 
EKVFKVYSEA GVTFT 

« Hide

References

[1]"Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux."
Burki F., Kaessmann H.
Nat. Genet. 36:1061-1063(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY588269 Genomic DNA. Translation: AAU03135.1.

3D structure databases

ProteinModelPortalQ64HZ9.
SMRQ64HZ9. Positions 60-555.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ64HZ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005479.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_HYLLA
AccessionPrimary (citable) accession number: Q64HZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: March 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families