Reviewed,
UniProtKB/Swiss-Prot Q64HZ8 (DHE4_PANTR)
Last modified
January 19, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutamate dehydrogenase 2, mitochondrial Short name=GDH 2 EC=1.4.1.3 | ||
| Gene names |
| ||
| Organism | Pan troglodytes (Chimpanzee) | ||
| Taxonomic identifier | 9598 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Protein attributes
| Sequence length | 558 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. |
| Catalytic activity | L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H. |
| Subunit structure | Homohexamer By similarity. |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the Glu/Leu/Phe/Val dehydrogenases family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 53 | 53 | Mitochondrion By similarity | ||||||
| Chain | 54 – 558 | 505 | Glutamate dehydrogenase 2, mitochondrial | PRO_0000007210 | |||||
Sites | |||||||||
| Active site | 183 | 1 | By similarity | ||||||
| Binding site | 84 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 415 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 457 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 527 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 545 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux." Burki F., Kaessmann H. Nat. Genet. 36:1061-1063(2004) [PubMed: 15378063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY588274 Genomic DNA. Translation: AAU03136.1. |
| RefSeq | NP_001009004.1. |
3D structure databases | |
| SMR | Q64HZ8. Positions 63-558. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q64HZ8. |
Genome annotation databases | |
| Ensembl | ENSPTRT00000005122; ENSPTRP00000004733; ENSPTRG00000028207; Pan troglodytes. [Genome view] |
| GeneID | 449581. |
| KEGG | ptr:449581. |
Organism-specific databases | |
| CTD | 449581. |
Phylogenomic databases | |
| eggNOG | prNOG10069. |
| HOVERGEN | Q64HZ8. |
| InParanoid | Q64HZ8. |
Enzyme and pathway databases | |
| BRENDA | 1.4.1.3. 264977. |
Family and domain databases | |
| InterPro | IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11606:SF2. GLFV_DH. 1 hit. |
| Pfam | PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view] |
| PRINTS | PR00082. GLFDHDRGNASE. |
| SMART | SM00839. ELFV_dehydrog. 1 hit. [Graphical view] |
| PROSITE | PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHE4_PANTR | ||||||||
| Accession | Primary (citable) accession number: Q64HZ8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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