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Q64HZ8 (DHE4_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate dehydrogenase 2, mitochondrial
Short name=GDH 2
EC=1.4.1.3
Gene names
Name:GLUD2
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

Catalytic activity

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Subunit structure

Homohexamer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Post-translational modification

Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   PTMADP-ribosylation
Acetylation
Gene Ontology (GO)
   Biological processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutamate dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5353Mitochondrion By similarity
Chain54 – 558505Glutamate dehydrogenase 2, mitochondrial
PRO_0000007210

Sites

Active site1831 By similarity
Binding site841Substrate By similarity

Amino acid modifications

Modified residue1721ADP-ribosylcysteine By similarity
Modified residue4151N6-acetyllysine By similarity
Modified residue4571N6-acetyllysine By similarity
Modified residue5271N6-acetyllysine By similarity
Modified residue5451N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64HZ8 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 9180BC7CB62C251D

FASTA55861,439
        10         20         30         40         50         60 
MYRYLAKALL TSRAGPAALG SAANHSAALL GRGPGQPAAA SQPGLALAAR RHYSELVADR 

        70         80         90        100        110        120 
EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 

       130        140        150        160        170        180 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 

       190        200        210        220        230        240 
GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY 

       250        260        270        280        290        300 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR 

       310        320        330        340        350        360 
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FRLQHGSLLG 

       370        380        390        400        410        420 
FPKAKPYEGS ILEIDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 

       430        440        450        460        470        480 
NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 

       490        500        510        520        530        540 
HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 

       550 
NAIEKVFKVY SEAGVTFT

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References

[1]"Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux."
Burki F., Kaessmann H.
Nat. Genet. 36:1061-1063(2004) [PubMed: 15378063] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY588274 Genomic DNA. Translation: AAU03136.1.
RefSeqNP_001009004.1. NM_001009004.1.
UniGenePtr.6132.

3D structure databases

ProteinModelPortalQ64HZ8.
SMRQ64HZ8. Positions 63-558.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ64HZ8.

Proteomic databases

PRIDEQ64HZ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID449581.
KEGGptr:449581.

Organism-specific databases

CTD2747.

Phylogenomic databases

eggNOGprNOG10069.
GeneTreeENSGT00390000000854.
HOVERGENHBG005479.
InParanoidQ64HZ8.
OrthoDBEOG41NTKQ.

Family and domain databases

InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00261.
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_PANTR
AccessionPrimary (citable) accession number: Q64HZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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