ID   CCL26_CANLF             Reviewed;          94 AA.
AC   Q64H35;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   RecName: Full=C-C motif chemokine 26 {ECO:0000303|Ref.1};
DE   AltName: Full=Eotaxin-3 {ECO:0000303|Ref.1};
DE   AltName: Full=Small-inducible cytokine A26;
DE   Flags: Precursor;
GN   Name=CCL26 {ECO:0000303|Ref.1};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Peters I.R., Peeters D., Clercx C., Day M.J.;
RT   "Identification of coding sequences for canine monocyte chemotactic
RT   protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine
RT   receptor 3 (CCR3).";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemoattractant for eosinophils and basophils. Acts as a
CC       ligand for C-C chemokine receptor CCR3 which triggers Ca(2+)
CC       mobilization in eosinophils. Also acts as a ligand for CX3C chemokine
CC       receptor CX3CR1, inducing cell chemotaxis.
CC       {ECO:0000250|UniProtKB:Q9Y258}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9Y258}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9Y258}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY675236; AAU14061.1; -; mRNA.
DR   RefSeq; NP_001005253.1; NM_001005253.1.
DR   AlphaFoldDB; Q64H35; -.
DR   SMR; Q64H35; -.
DR   STRING; 9615.ENSCAFP00000040578; -.
DR   PaxDb; 9612-ENSCAFP00000040578; -.
DR   Ensembl; ENSCAFT00000043418.3; ENSCAFP00000040578.1; ENSCAFG00000032573.3.
DR   Ensembl; ENSCAFT00040024304.1; ENSCAFP00040021118.1; ENSCAFG00040013153.1.
DR   Ensembl; ENSCAFT00805002142; ENSCAFP00805001669; ENSCAFG00805001182.
DR   Ensembl; ENSCAFT00845007282.1; ENSCAFP00845005786.1; ENSCAFG00845004038.1.
DR   GeneID; 448789; -.
DR   KEGG; cfa:448789; -.
DR   CTD; 10344; -.
DR   VEuPathDB; HostDB:ENSCAFG00845004038; -.
DR   VGNC; VGNC:38888; CCL26.
DR   eggNOG; ENOG502T082; Eukaryota.
DR   GeneTree; ENSGT01100000263482; -.
DR   HOGENOM; CLU_141716_6_0_1; -.
DR   InParanoid; Q64H35; -.
DR   OMA; CAHPKEK; -.
DR   OrthoDB; 4265193at2759; -.
DR   TreeFam; TF334888; -.
DR   Proteomes; UP000002254; Chromosome 6.
DR   Proteomes; UP000694429; Unplaced.
DR   Proteomes; UP000694542; Chromosome 6.
DR   Proteomes; UP000805418; Chromosome 6.
DR   Bgee; ENSCAFG00000032573; Expressed in jejunum and 16 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031728; F:CCR3 chemokine receptor binding; IEA:Ensembl.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0031737; F:CX3C chemokine receptor binding; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0050921; P:positive regulation of chemotaxis; IEA:Ensembl.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF73; C-C MOTIF CHEMOKINE 26; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..94
FT                   /note="C-C motif chemokine 26"
FT                   /id="PRO_0000005237"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y258"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y258"
SQ   SEQUENCE   94 AA;  11012 MW;  FAC1A201F0981C29 CRC64;
     MKSFPVAFLV LLIFILSVHR GVTTRGSDVA KFCCFQYSHK ILPWKWIQSY KFTRSSCSQQ
     AVIFTTKKGH KVCAQPKEKW VQRYIALLRE QQQS
//