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Q64H35

- CCL26_CANFA

UniProt

Q64H35 - CCL26_CANFA

Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic for eosinophils and basophils. Binds to CCR3 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW
    4. positive regulation of actin filament polymerization Source: Ensembl
    5. positive regulation of cell migration Source: Ensembl
    6. positive regulation of endothelial cell proliferation Source: Ensembl
    7. positive regulation of Rac GTPase activity Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 26
    Alternative name(s):
    Eotaxin-3
    Small-inducible cytokine A26
    Gene namesi
    Name:CCL26
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 6

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9471C-C motif chemokine 26PRO_0000005237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000019729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64H35.
    SMRiQ64H35. Positions 24-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG69247.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ64H35.
    KOiK05514.
    OMAiWRTESMA.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64H35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSFPVAFLV LLIFILSVHR GVTTRGSDVA KFCCFQYSHK ILPWKWIQSY   50
    KFTRSSCSQQ AVIFTTKKGH KVCAQPKEKW VQRYIALLRE QQQS 94
    Length:94
    Mass (Da):11,012
    Last modified:October 25, 2004 - v1
    Checksum:iFAC1A201F0981C29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY675236 mRNA. Translation: AAU14061.1.
    RefSeqiNP_001005253.1. NM_001005253.1.
    UniGeneiCfa.15813.

    Genome annotation databases

    EnsembliENSCAFT00000043418; ENSCAFP00000040578; ENSCAFG00000032573.
    GeneIDi448789.
    KEGGicfa:448789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY675236 mRNA. Translation: AAU14061.1 .
    RefSeqi NP_001005253.1. NM_001005253.1.
    UniGenei Cfa.15813.

    3D structure databases

    ProteinModelPortali Q64H35.
    SMRi Q64H35. Positions 24-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000019729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000043418 ; ENSCAFP00000040578 ; ENSCAFG00000032573 .
    GeneIDi 448789.
    KEGGi cfa:448789.

    Organism-specific databases

    CTDi 10344.

    Phylogenomic databases

    eggNOGi NOG69247.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q64H35.
    KOi K05514.
    OMAi WRTESMA.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20832519.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
      Peters I.R., Peeters D., Clercx C., Day M.J.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL26_CANFA
    AccessioniPrimary (citable) accession number: Q64H35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3