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Q64H35

- CCL26_CANFA

UniProt

Q64H35 - CCL26_CANFA

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Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemotactic for eosinophils and basophils. Binds to CCR3 (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. positive regulation of actin filament polymerization Source: Ensembl
  5. positive regulation of cell migration Source: Ensembl
  6. positive regulation of endothelial cell proliferation Source: Ensembl
  7. positive regulation of Rac GTPase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 26
Alternative name(s):
Eotaxin-3
Small-inducible cytokine A26
Gene namesi
Name:CCL26
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9471C-C motif chemokine 26PRO_0000005237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019729.

Structurei

3D structure databases

ProteinModelPortaliQ64H35.
SMRiQ64H35. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69247.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ64H35.
KOiK05514.
OMAiWRTESMA.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64H35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSFPVAFLV LLIFILSVHR GVTTRGSDVA KFCCFQYSHK ILPWKWIQSY
60 70 80 90
KFTRSSCSQQ AVIFTTKKGH KVCAQPKEKW VQRYIALLRE QQQS
Length:94
Mass (Da):11,012
Last modified:October 25, 2004 - v1
Checksum:iFAC1A201F0981C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675236 mRNA. Translation: AAU14061.1.
RefSeqiNP_001005253.1. NM_001005253.1.
UniGeneiCfa.15813.

Genome annotation databases

EnsembliENSCAFT00000043418; ENSCAFP00000040578; ENSCAFG00000032573.
GeneIDi448789.
KEGGicfa:448789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675236 mRNA. Translation: AAU14061.1 .
RefSeqi NP_001005253.1. NM_001005253.1.
UniGenei Cfa.15813.

3D structure databases

ProteinModelPortali Q64H35.
SMRi Q64H35. Positions 24-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000019729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000043418 ; ENSCAFP00000040578 ; ENSCAFG00000032573 .
GeneIDi 448789.
KEGGi cfa:448789.

Organism-specific databases

CTDi 10344.

Phylogenomic databases

eggNOGi NOG69247.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q64H35.
KOi K05514.
OMAi WRTESMA.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20832519.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL26_CANFA
AccessioniPrimary (citable) accession number: Q64H35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3