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Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chemotactic for eosinophils and basophils. Binds to CCR3 (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. positive regulation of actin filament polymerization Source: Ensembl
  5. positive regulation of cell migration Source: Ensembl
  6. positive regulation of endothelial cell proliferation Source: Ensembl
  7. positive regulation of Rac GTPase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 26
Alternative name(s):
Eotaxin-3
Small-inducible cytokine A26
Gene namesi
Name:CCL26
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9471C-C motif chemokine 26PRO_0000005237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019729.

Structurei

3D structure databases

ProteinModelPortaliQ64H35.
SMRiQ64H35. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69247.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ64H35.
KOiK05514.
OMAiCSQQAVI.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64H35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSFPVAFLV LLIFILSVHR GVTTRGSDVA KFCCFQYSHK ILPWKWIQSY
60 70 80 90
KFTRSSCSQQ AVIFTTKKGH KVCAQPKEKW VQRYIALLRE QQQS
Length:94
Mass (Da):11,012
Last modified:October 25, 2004 - v1
Checksum:iFAC1A201F0981C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675236 mRNA. Translation: AAU14061.1.
RefSeqiNP_001005253.1. NM_001005253.1.
UniGeneiCfa.15813.

Genome annotation databases

EnsembliENSCAFT00000043418; ENSCAFP00000040578; ENSCAFG00000032573.
GeneIDi448789.
KEGGicfa:448789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675236 mRNA. Translation: AAU14061.1.
RefSeqiNP_001005253.1. NM_001005253.1.
UniGeneiCfa.15813.

3D structure databases

ProteinModelPortaliQ64H35.
SMRiQ64H35. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000043418; ENSCAFP00000040578; ENSCAFG00000032573.
GeneIDi448789.
KEGGicfa:448789.

Organism-specific databases

CTDi10344.

Phylogenomic databases

eggNOGiNOG69247.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ64H35.
KOiK05514.
OMAiCSQQAVI.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Miscellaneous databases

NextBioi20832519.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL26_CANFA
AccessioniPrimary (citable) accession number: Q64H35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 25, 2004
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.