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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7410CytoplasmicSequence analysis
Transmembranei75 – 9521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini96 – 11217ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 20631ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini228 – 24316CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 28824ExtracellularSequence analysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini310 – 35950CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-C chemokine receptor type 3PRO_0000069236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441PhosphoserineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64H34.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020344.

Structurei

3D structure databases

ProteinModelPortaliQ64H34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ64H34.
KOiK04178.
OMAiLLRCPSK.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64H34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTAEIKT MDESIQTTVF DYENSLPCEK VNIKHLGAQF LPPLYSLVFV
60 70 80 90 100
IGLLGNVVVV VILTKYKRLW IMTNIFLLNL AISDLLFLFT LVFWIHYTGW
110 120 130 140 150
NDWVFGRSMC KLISGLYYLG LYGEIFFIIL LTIDRYLAIV HAVFALRART
160 170 180 190 200
VTFGIITSVL TWGLAGLAAL PEFIFHESQK ESEQFVCTPL YPKDQEDNWK
210 220 230 240 250
RFHALRMNIL GLALPLLIMV VCYSGIIKTL LRCPSKKKYK AIRLIFVIMV
260 270 280 290 300
VFFIFWTPYN LVLLLSAFQT IFFETTCEQS KQLDVAMQIT EVIAYTHCCI
310 320 330 340 350
NPIIYAFVGE RFRKHLCHFF RRNVATYLGK YIPFLPSEKL ERSSSVSPST

GEQEFSFVF
Length:359
Mass (Da):41,496
Last modified:October 25, 2004 - v1
Checksum:i7F8D6EB5D98615D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891F → S in BAD83841 (Ref. 2) Curated
Sequence conflicti170 – 1701L → S in BAD83841 (Ref. 2) Curated
Sequence conflicti203 – 2031H → D in BAD83841 (Ref. 2) Curated
Sequence conflicti255 – 2551F → L in BAD83841 (Ref. 2) Curated
Sequence conflicti261 – 2611L → R in BAD83841 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675237 mRNA. Translation: AAU14062.1.
AB183193 mRNA. Translation: BAD83841.1.
RefSeqiNP_001005261.1. NM_001005261.1.
XP_005632374.1. XM_005632317.2.
UniGeneiCfa.30412.

Genome annotation databases

GeneIDi448802.
KEGGicfa:448802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675237 mRNA. Translation: AAU14062.1.
AB183193 mRNA. Translation: BAD83841.1.
RefSeqiNP_001005261.1. NM_001005261.1.
XP_005632374.1. XM_005632317.2.
UniGeneiCfa.30412.

3D structure databases

ProteinModelPortaliQ64H34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020344.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ64H34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448802.
KEGGicfa:448802.

Organism-specific databases

CTDi1232.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ64H34.
KOiK04178.
OMAiLLRCPSK.

Miscellaneous databases

NextBioi20832530.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression analysis of CCR3 gene in canine atopic dermatitis."
    Tsukui T., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K., Sakaguchi M., Tsujimoto H., Iwabuchi S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCR3_CANLF
AccessioniPrimary (citable) accession number: Q64H34
Secondary accession number(s): Q5KSV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.