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Protein
Submitted name:

Fiber

Gene

L5

Organism
Human adenovirus D37
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121MagnesiumCombined sources
Metal bindingi365 – 3651MagnesiumCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
FiberImported
Submitted name:
Fiber proteinImported
Gene namesi
Name:L5Imported
OrganismiHuman adenovirus D37Imported
Taxonomic identifieri52275 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusHuman mastadenovirus D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UXAX-ray1.50A/B/C174-365[»]
1UXEX-ray2.00A/B/C174-365[»]
2WBWX-ray1.55A177-365[»]
2WGTX-ray1.80A/B/C177-365[»]
2WGUX-ray1.80A/B/C177-365[»]
3N0IX-ray1.65A/B/C177-365[»]
3QNDX-ray2.40A/B/C/E/F/G177-365[»]
4K6TX-ray2.00A/B/C/E/F/G177-365[»]
4K6UX-ray1.90A/B/C177-365[»]
4K6VX-ray1.50A/B/C177-365[»]
4K6WX-ray1.50A/B/C177-365[»]
4XQAX-ray1.41A/B/C177-365[»]
4XQBX-ray1.60A/B/C177-365[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 361176Adeno_knobInterPro annotationAdd
BLAST

Family and domain databases

Gene3Di2.10.25.20. 2 hits.
2.60.90.10. 1 hit.
InterProiIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamiPF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 2 hits.
[Graphical view]
PRINTSiPR00307. ADENOVSFIBRE.
SUPFAMiSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 2 hits.

Sequencei

Sequence statusi: Complete.

Q64823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLRVEDD FNPVYPYGYA RNQNIPFLTP PFVSSDGFKN FPPGVLSLKL
60 70 80 90 100
ADPITITNGD VSLKVGGGLT LQDGSLTVNP KAPLQVNTDK KLELAYDNPF
110 120 130 140 150
ESSANKLSLK VGHGLKVLDE KSAAGLKDLI GKLVVLTGKG IGTENLENTD
160 170 180 190 200
GSSRGIGINV RAREGLTFDN DGYLVAWNPK YDTRTLWTTP DTSPNCTIAQ
210 220 230 240 250
DKDSKLTLVL TKCGSQILAN VSLIVVAGKY HIINNKTNPK IKSFTIKLLF
260 270 280 290 300
NKNGVLLDNS NLGKAYWNFR SGNSNVSTAY EKAIGFMPNL VAYPKPSNSK
310 320 330 340 350
KYARDIVYGT IYLGGKPDQP AVIKTTFNQE TGCEYSITFN FSWSKTYENV
360
EFETTSFTFS YIAQE
Length:365
Mass (Da):40,093
Last modified:January 1, 1998 - v2
Checksum:i2F713268BD55AD80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69132 Genomic DNA. Translation: AAB71734.1.
DQ900900 Genomic DNA. Translation: ABK59080.1.
AB369370 Genomic DNA. Translation: BAG69150.1.
AB448775 Genomic DNA. Translation: BAH19086.1.
AB448776 Genomic DNA. Translation: BAH19122.1.
X94484 Genomic DNA. Translation: CAA64230.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69132 Genomic DNA. Translation: AAB71734.1.
DQ900900 Genomic DNA. Translation: ABK59080.1.
AB369370 Genomic DNA. Translation: BAG69150.1.
AB448775 Genomic DNA. Translation: BAH19086.1.
AB448776 Genomic DNA. Translation: BAH19122.1.
X94484 Genomic DNA. Translation: CAA64230.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UXAX-ray1.50A/B/C174-365[»]
1UXEX-ray2.00A/B/C174-365[»]
2WBWX-ray1.55A177-365[»]
2WGTX-ray1.80A/B/C177-365[»]
2WGUX-ray1.80A/B/C177-365[»]
3N0IX-ray1.65A/B/C177-365[»]
3QNDX-ray2.40A/B/C/E/F/G177-365[»]
4K6TX-ray2.00A/B/C/E/F/G177-365[»]
4K6UX-ray1.90A/B/C177-365[»]
4K6VX-ray1.50A/B/C177-365[»]
4K6WX-ray1.50A/B/C177-365[»]
4XQAX-ray1.41A/B/C177-365[»]
4XQBX-ray1.60A/B/C177-365[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.10.25.20. 2 hits.
2.60.90.10. 1 hit.
InterProiIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamiPF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 2 hits.
[Graphical view]
PRINTSiPR00307. ADENOVSFIBRE.
SUPFAMiSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Fiber genes of adenoviruses with tropism for the eye and the genital tract."
    Arnberg N., Mei Y.f., Wadell G.
    Virology 227:239-244(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GWImported.
  2. Zverlov V.V.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites."
    Burmeister W.P., Guilligay D., Cusack S., Wadell G., Arnberg N.
    J. Virol. 78:7727-7736(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 174-365.
  4. "Genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism."
    Robinson C.M., Shariati F., Gillaspy A.F., Dyer D.W., Chodosh J.
    BMC Genomics 9:213-213(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GW [76-19026]Imported.
  5. "Epidemic keratoconjunctivitis due to the novel hexon-chimeric-intermediate 22,37/H8 human adenovirus."
    Aoki K., Ishiko H., Konno T., Shimada Y., Hayashi A., Kaneko H., Ohguchi T., Tagawa Y., Ohno S., Yamazaki S.
    J. Clin. Microbiol. 46:3259-3269(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GWImported.
  6. "Analysis of the complete genome sequence of epidemic keratoconjunctivitis-related human adenovirus type 8, 19, 37 and a novel serotype."
    Kaneko H., Iida T., Ishiko H., Ohguchi T., Ariga T., Tagawa Y., Aoki K., Ohno S., Suzutani T.
    J. Gen. Virol. 90:1471-1476(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1991Imported and GWImported.
  7. "Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis."
    Johansson S., Nilsson E., Qian W., Guilligay D., Crepin T., Cusack S., Arnberg N., Elofsson M.
    J. Med. Chem. 52:3666-3678(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 177-365.
  8. "The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution."
    Seiradake E., Henaff D., Wodrich H., Billet O., Perreau M., Hippert C., Mennechet F., Schoehn G., Lortat-Jacob H., Dreja H., Ibanes S., Kalatzis V., Wang J.P., Finberg R.W., Cusack S., Kremer E.J.
    PLoS Pathog. 5:e1000277-e1000277(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 177-365.
  9. Baldwin C., Mounts J., Smith D., Weigt L.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GW [76-19026]Imported.
  10. "A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells."
    Spjut S., Qian W., Bauer J., Storm R., Frangsmyr L., Stehle T., Arnberg N., Elofsson M.
    Angew. Chem. Int. Ed. 50:6519-6521(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 177-365.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 177-365.
  12. "Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells."
    Caraballo R., Saleeb M., Bauer J., Liaci A.M., Chandra N., Storm R.J., Frangsmyr L., Qian W., Stehle T., Arnberg N., Elofsson M.
    Org. Biomol. Chem. 13:9194-9205(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 177-365 IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiQ64823_9ADEN
AccessioniPrimary (citable) accession number: Q64823
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.