ID   Q647J8_HUMAN            Unreviewed;       144 AA.
AC   Q647J8;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   03-MAY-2023, entry version 83.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor {ECO:0000256|ARBA:ARBA00018697};
DE   AltName: Full=Colony-stimulating factor {ECO:0000256|ARBA:ARBA00029601};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAU21240.1};
RN   [1] {ECO:0000313|EMBL:AAU21240.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Li C.;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC       hematopoietic precursor cells from various lineages, including
CC       granulocytes, macrophages, eosinophils and erythrocytes.
CC       {ECO:0000256|ARBA:ARBA00003164}.
CC   -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC       of two head-to-head hexamers of two alpha, two beta, and two ligand
CC       subunits. {ECO:0000256|ARBA:ARBA00025874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the GM-CSF family.
CC       {ECO:0000256|ARBA:ARBA00009378}.
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DR   EMBL; AY720441; AAU21240.1; -; mRNA.
DR   AlphaFoldDB; Q647J8; -.
DR   PeptideAtlas; Q647J8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00040; CSF2; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000773; GM_colony-stim-fac.
DR   PANTHER; PTHR10059:SF0; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10059; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GM-CSF; 1.
DR   Pfam; PF01109; GM_CSF; 1.
DR   PRINTS; PR00693; GMCSFACTOR.
DR   SMART; SM00040; CSF2; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00702; GM_CSF; 1.
PE   2: Evidence at transcript level;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..144
FT                   /note="Granulocyte-macrophage colony-stimulating factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004267550"
SQ   SEQUENCE   144 AA;  16269 MW;  75D1E0B9D4D1A1A8 CRC64;
     MWLQSLLLLG TVACSISAPG RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI
     SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQTITF
     ESFKENLKDF LLVIPFDCWE PVQE
//