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Protein

Collagen alpha-2(XI) chain

Gene

Col11a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1589CalciumBy similarity1
Metal bindingi1591CalciumBy similarity1
Metal bindingi1592Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1594Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1597CalciumBy similarity1

GO - Molecular functioni

  • extracellular matrix structural constituent Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cartilage development Source: MGI
  • chondrocyte differentiation Source: MGI
  • collagen fibril organization Source: MGI
  • osteoblast differentiation Source: Ensembl
  • palate development Source: MGI
  • sensory perception of sound Source: MGI
  • skeletal system development Source: MGI
  • skeletal system morphogenesis Source: MGI
  • soft palate development Source: MGI
  • tissue homeostasis Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-8874081. MET activates PTK2 signaling.
R-MMU-8948216. Collagen chain trimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-2(XI) chain
Gene namesi
Name:Col11a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88447. Col11a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000584228 – 1736Collagen alpha-2(XI) chainAdd BLAST1709
PropeptideiPRO_00000058431501 – 1736C-terminal propeptideAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1571 ↔ 1603PROSITE-ProRule annotation
Disulfide bondi1577InterchainPROSITE-ProRule annotation
Disulfide bondi1594InterchainPROSITE-ProRule annotation
Glycosylationi1604N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1612 ↔ 1733PROSITE-ProRule annotation
Disulfide bondi1655 ↔ 1689PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ64739.
PRIDEiQ64739.

PTM databases

iPTMnetiQ64739.
PhosphoSitePlusiQ64739.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024330.
CleanExiMM_COL11A2.
ExpressionAtlasiQ64739. baseline and differential.
GenevisibleiQ64739. MM.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ64739.
SMRiQ64739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 228Laminin G-likeAdd BLAST172
Domaini399 – 447Collagen-like 1Add BLAST49
Domaini487 – 545Collagen-like 2Add BLAST59
Domaini546 – 583Collagen-like 3Add BLAST38
Domaini682 – 737Collagen-like 4Add BLAST56
Domaini868 – 924Collagen-like 5Add BLAST57
Domaini967 – 1025Collagen-like 6Add BLAST59
Domaini1026 – 1055Collagen-like 7Add BLAST30
Domaini1056 – 1086Collagen-like 8Add BLAST31
Domaini1114 – 1172Collagen-like 9Add BLAST59
Domaini1393 – 1447Collagen-like 10Add BLAST55
Domaini1448 – 1499Collagen-like 11Add BLAST52
Domaini1541 – 1735Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 486Nonhelical regionAdd BLAST272
Regioni487 – 1500Triple-helical regionAdd BLAST1014

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00900000140789.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
InParanoidiQ64739.
KOiK19721.
OMAiQKGTKGN.
OrthoDBiEOG091G01AE.
PhylomeDBiQ64739.
TreeFamiTF323987.

Family and domain databases

Gene3Di2.160.20.50. 11 hits.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR013320. ConA-like_dom_sf.
IPR000885. Fib_collagen_C.
IPR016133. Insect_cyst_antifreeze_prot.
IPR001791. Laminin_G.
PfamiView protein in Pfam
PF01410. COLFI. 2 hits.
PF01391. Collagen. 7 hits.
PF02210. Laminin_G_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078. Fib_collagen_C. 1 hit.
SMARTiView protein in SMART
SM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51461. NC1_FIB. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q64739-2) [UniParc]FASTAAdd to basket
Also known as: E56789

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERCSRCHRL LLFLPLVLGL SAAPGWAGAP SVDVLRALRF PSLPDGVRRS
60 70 80 90 100
KGVCPGDVAY RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL
110 120 130 140 150
LTLYSAQGVQ QLGLELGRPV RFLYEDQRGR PQASAQPIFR GLSLADGKWH
160 170 180 190 200
HVAVAVKGQS VTLIVDCKKR VTRPLPRSVH PVLDTHGVVI FGAHILDDEV
210 220 230 240 250
FEGDVQELLV VPGVQAAYQS CGQKDLECER EQRDGPQTQK PHRAQRSPKK
260 270 280 290 300
EPARLHKPQS QEPQKQPTES LYYDYEPPYY DVMTTGTAPD YQYPTPGEEE
310 320 330 340 350
GVLESSPLPF LEEEQTDLQV SPTADSFQAE EYGEGGTDSP AGFYDYTYGY
360 370 380 390 400
GDDYREETEL GPALSAETAH SGAVAHGPRG LKGEKGEPAV LEPGMFVEGP
410 420 430 440 450
PGPEGPAGLA GPPGIQGNPG PVGDPGERGP PGRAGLPGSD GPPGPPGTSL
460 470 480 490 500
MLPFRFGSSG GDKGPVVAAQ EAQAQAILQQ ARLALRGPPG PMGYTGRPGP
510 520 530 540 550
LGQPGSPGLK GESGDLGPQG PRGPQGLTGP PGKAGRRGRA GADGARGMPG
560 570 580 590 600
EPGMKGDRGF DGLPGLPGEK GQRGDTGAQG LPGPPGEDGE RGDDGEIGPR
610 620 630 640 650
GLPGESGPRG LLGPKGPPGI PGPPGVRGMD GPHGPKGSLG PQGEPGPPGQ
660 670 680 690 700
QGTPGAQGLP GPQGAIGPHG EKGARGKPGL PGMPGSDGLP GHPGKEGPPG
710 720 730 740 750
TKGNQGPSGP QGPLGYPGPR GVKGVDGIRG LKGHKGEKGE DGFPGFKGDI
760 770 780 790 800
GVKGDRGEVG VPGSRGEDGP EGPKGRTGPT GDPGPTGLMG EKGKLGVPGL
810 820 830 840 850
PGYPGRQGPK GSLGFPGFPG ASGEKGARGL SGKSGPRGER GPTGPRGQRG
860 870 880 890 900
PRGATGKSGA KGTSGGDGPH GPPGERGLPG PQGPNGFPGP KGPPGPAGKD
910 920 930 940 950
GLPGHPGQRG EVGFQGKTGP PGPPGVVGPQ GTAGESGPMG ERGHSGPPGP
960 970 980 990 1000
PGEQGLPGTS GKEGTKGDPG PPGAPGKDGP AGLRGFPGER GLPGTAGGPG
1010 1020 1030 1040 1050
LKGNEGPAGP PGPAGSPGER GAAGSGGPIG PPGRPGPQGP PGAAGEKGVP
1060 1070 1080 1090 1100
GEKGPIGPTG RDGVQGPVGL PGPAGPPGVA GEDGDKGEVG DPGQKGTKGN
1110 1120 1130 1140 1150
KGEHGPPGPP GPIGPVGQPG AAGADGEPGA RGPQGHFGAK GDEGTRGFNG
1160 1170 1180 1190 1200
PPGPIGLQGL PGPSGEKGET GDGGPMGPPG PPGPRGPAGP NGADGPQGSP
1210 1220 1230 1240 1250
GGVGNLGPPG EKGEPGESGS PGVQGEPGVK GPRGERGEKG ESGQAGEAGP
1260 1270 1280 1290 1300
PGPKGPTGDN GPKGNPGPVG FPGDPGPPGE AGPRGQDGAK GDRGEDGEPG
1310 1320 1330 1340 1350
QPGSPGPTGE NGPPGPLGKR GPAGTPGPEG RQGEKGAKGD PGAVGAPGKT
1360 1370 1380 1390 1400
GPVGPAGLAG KPGPDGLRGL PGSVGQQGRP GATGQAGPPG PVGPPGLPGL
1410 1420 1430 1440 1450
RGDAGAKGEK GHPGLIGLIG PTGEQGEKGD RGLPGPQGSP GQKGETGIPG
1460 1470 1480 1490 1500
ASGPIGPGGP PGLPGPSGPK GAKGATGPAG PKGEKGVQGP PGHPGPPGEV
1510 1520 1530 1540 1550
IQPLPIQMPK KTRRSVDGSK LIQDEEAVPT GGAPGSPAGL EEIFGSLDSL
1560 1570 1580 1590 1600
REEIEQMRRP AGTQDSPART CQDLKLCHPE LPDGEYWVDP NQGCARDAFR
1610 1620 1630 1640 1650
VFCNFTAGGE TCVTPRDDVT QFSYVDSEGS PVGVVQLTFL RLLSVSAHQD
1660 1670 1680 1690 1700
VSYPCSGVSQ DGPLKLRGAN EDELSPETSP YVKEFRDGCQ TQQGRTVLEV
1710 1720 1730
RTPVLEQLPV LDASFADLGA PTRRGGVLLG PVCFMG
Length:1,736
Mass (Da):171,535
Last modified:April 30, 2003 - v3
Checksum:i18D792D4A3387C61
GO
Isoform 2 (identifier: Q64739-3) [UniParc]FASTAAdd to basket
Also known as: E5689

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Show »
Length:1,715
Mass (Da):169,234
Checksum:iCC2B4D1773123877
GO
Isoform 3 (identifier: Q64739-4) [UniParc]FASTAAdd to basket
Also known as: E5789

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.

Show »
Length:1,710
Mass (Da):168,473
Checksum:i8BAB1973804954C2
GO
Isoform 4 (identifier: Q64739-5) [UniParc]FASTAAdd to basket
Also known as: E569

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.
     314-373: Missing.

Show »
Length:1,655
Mass (Da):162,833
Checksum:i28ECA47A24C6174B
GO
Isoform 5 (identifier: Q64739-6) [UniParc]FASTAAdd to basket
Also known as: E589

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.

Show »
Length:1,689
Mass (Da):166,172
Checksum:iFBBF356DBACE1482
GO
Isoform 6 (identifier: Q64739-7) [UniParc]FASTAAdd to basket
Also known as: E59

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.
     314-373: Missing.

Show »
Length:1,629
Mass (Da):159,771
Checksum:i618E1167953435BF
GO
Isoform 7 (identifier: Q64739-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     314-373: Missing.

Show »
Length:1,650
Mass (Da):162,072
Checksum:i8ECDB8702E71E2DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti536R → L in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti621P → S in BAA18910 (PubMed:7836472).Curated1
Sequence conflicti704 – 705NQ → KP in AAA67751 (PubMed:8981332).Curated2
Sequence conflicti797V → A in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti843 – 845TGP → HGS in AAA67751 (PubMed:8981332).Curated3
Sequence conflicti854A → S in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti876R → G in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti889G → V in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti922G → D in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1005E → V in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1253P → S in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1386A → T in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1522I → M in AAA67751 (PubMed:8981332).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007345267 – 292Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_007346293 – 313Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_007347314 – 373Missing in isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100956 Genomic DNA. Translation: AAC69905.1.
U16789 mRNA. Translation: AAA67751.1.
U16790 Genomic DNA. Translation: AAA67752.1.
D38412 mRNA. Translation: BAA18910.1.
D84066 Genomic DNA. Translation: BAA12208.1.
CCDSiCCDS28640.1. [Q64739-1]
PIRiA55576.
RefSeqiNP_001304651.1. NM_001317722.1. [Q64739-3]
NP_034056.1. NM_009926.2. [Q64739-1]
XP_006523627.1. XM_006523564.3. [Q64739-2]
XP_006523629.1. XM_006523566.3. [Q64739-4]
XP_006523630.1. XM_006523567.3. [Q64739-6]
XP_006523632.1. XM_006523569.3. [Q64739-5]
XP_006523633.1. XM_006523570.3. [Q64739-7]
UniGeneiMm.20230.

Genome annotation databases

EnsembliENSMUST00000087497; ENSMUSP00000084772; ENSMUSG00000024330. [Q64739-1]
ENSMUST00000114252; ENSMUSP00000109890; ENSMUSG00000024330. [Q64739-5]
ENSMUST00000114255; ENSMUSP00000109893; ENSMUSG00000024330. [Q64739-6]
GeneIDi12815.
KEGGimmu:12815.
UCSCiuc056zel.1. mouse. [Q64739-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCOBA2_MOUSE
AccessioniPrimary (citable) accession number: Q64739
Secondary accession number(s): Q61432, Q9Z1W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 30, 2003
Last modified: November 22, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families