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Q64737

- PUR2_MOUSE

UniProt

Q64737 - PUR2_MOUSE

Protein

Trifunctional purine biosynthetic protein adenosine-3

Gene

Gart

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
    10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi288 – 2881ManganeseBy similarity
    Metal bindingi290 – 2901ManganeseBy similarity
    Binding sitei871 – 871110-formyltetrahydrofolateBy similarity
    Binding sitei913 – 913110-formyltetrahydrofolateBy similarity
    Active sitei915 – 9151Proton donorBy similarity
    Sitei951 – 9511Raises pKa of active site HisBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi137 – 19963ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methyltransferase activity Source: InterPro
    4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-EC
    5. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC
    6. phosphoribosylglycinamide formyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. brainstem development Source: Ensembl
    3. cerebellum development Source: Ensembl
    4. cerebral cortex development Source: Ensembl
    5. glycine metabolic process Source: Ensembl
    6. purine nucleobase biosynthetic process Source: InterPro
    7. response to inorganic substance Source: Ensembl
    8. response to organic substance Source: Ensembl
    9. tetrahydrofolate biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RKQ64737.
    UniPathwayiUPA00074; UER00125.
    UPA00074; UER00126.
    UPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trifunctional purine biosynthetic protein adenosine-3
    Including the following 3 domains:
    Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
    Alternative name(s):
    Glycinamide ribonucleotide synthetase
    Short name:
    GARS
    Phosphoribosylglycinamide synthetase
    Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
    Alternative name(s):
    AIR synthase
    Short name:
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    Phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)
    Alternative name(s):
    5'-phosphoribosylglycinamide transformylase
    GAR transformylase
    Short name:
    GART
    Gene namesi
    Name:Gart
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:95654. Gart.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 10101009Trifunctional purine biosynthetic protein adenosine-3PRO_0000074938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei350 – 3501N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ64737.
    PaxDbiQ64737.
    PRIDEiQ64737.

    PTM databases

    PhosphoSiteiQ64737.

    Expressioni

    Tissue specificityi

    Detected in liver, kidney and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ64737.
    BgeeiQ64737.
    CleanExiMM_GART.
    GenevestigatoriQ64737.

    Interactioni

    Protein-protein interaction databases

    BioGridi199831. 1 interaction.
    IntActiQ64737. 1 interaction.
    MINTiMINT-1852011.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64737.
    SMRiQ64737. Positions 1-430, 475-785, 808-1006.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 318208ATP-graspAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni434 – 807374AIRSAdd
    BLAST
    Regioni808 – 1010203GARTAdd
    BLAST
    Regioni818 – 82035'-phosphoribosylglycinamide bindingBy similarity
    Regioni896 – 899410-formyltetrahydrofolate bindingBy similarity
    Regioni947 – 951510-formyltetrahydrofolate bindingBy similarity
    Regioni977 – 98045'-phosphoribosylglycinamide bindingBy similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the GARS family.Curated
    In the central section; belongs to the AIR synthase family.Curated
    In the C-terminal section; belongs to the GART family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    eggNOGiCOG0151.
    GeneTreeiENSGT00390000000292.
    HOGENOMiHOG000030315.
    HOVERGENiHBG008333.
    InParanoidiQ3TGI3.
    KOiK11787.
    OMAiTARYESF.
    OrthoDBiEOG7RBZ7H.
    TreeFamiTF106368.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.170. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00138. GARS.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR002376. Formyl_transf_N.
    IPR001555. GART_AS.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    IPR004607. PurN_trans.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00877. purD. 1 hit.
    TIGR00878. purM. 1 hit.
    TIGR00639. PurN. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    PS00373. GART. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q64737-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARVLVIGS GGREHTLAWK LAQSPQVKQV LVAPGNAGTA CAGKISNAAV     50
    SVNDHSALAQ FCKDEKIELV VVGPEAPLAA GIVGDLTSAG VRCFGPTAQA 100
    AQLESSKKFA KEFMDRHEIP TAQWRAFTNP EDACSFITSA NFPALVVKAS 150
    GLAAGKGVIV AKSQAEACRA VQEIMQEKSF GAAGETVVVE EFLEGEEVSC 200
    LCFTDGKTVA EMPPAQDHKR LLDGDEGPNT GGMGAYCPAP QVSKDLLVKI 250
    KNTILQRAVD GMQQEGAPYT GILYAGIMLT KDGPKVLEFN CRFGDPECQV 300
    ILPLLKSDLY EVMQSTLDGL LSASLPVWLE NHSAVTVVMA SKGYPGAYTK 350
    GVEITGFPEA QALGLQVFHA GTALKDGKVV TSGGRVLTVT AVQENLMSAL 400
    AEARKGLAAL KFEGAIYRKD IGFRAVAFLQ RPRGLTYKDS GVDIAAGNML 450
    VKKIQPLAKA TSRPGCSVDL GGFAGLFDLK AAGFKDPLLA SGTDGVGTKL 500
    KIAQLCNKHD SIGQDLVAMC VNDILAQGAE PLFFLDYFSC GKLDLSTTEA 550
    VIAGIAAACQ QAGCALLGGE TAEMPNMYPP GEYDLAGFAV GAMERHQKLP 600
    QLERITEGDA VIGVASSGLH SNGFSLVRKI VERSSLQYSS PAPGGCGDQT 650
    LGDLLLTPTR IYSHSLLPII RSGRVKAFAH ITGGGLLENI PRVLPQKFGV 700
    DLDASTWRVP KVFSWLQQEG ELSEEEMART FNCGIGAALV VSKDQAEQVL 750
    HDVRRRQEEA WVIGSVVACP EDSPRVRVKN LIETIQTNGS LVANGFLKSN 800
    FPVQQKKARV AVLISGTGSN LQALIDSTRD PKSSSHIVLV ISNKAAVAGL 850
    DRAERAGIPT RVINHKLYKN RVEFDNAVDH VLEEFSVDIV CLAGFMRILS 900
    GPFVRKWDGK MLNIHPSLLP SFKGSNAHEQ VLEAGVTITG CTVHFVAEDV 950
    DAGQIILQEA VPVRRGDTVA TLSERVKVAE HKIFPAALQL VASGAVQLRE 1000
    DGKIHWAKEQ 1010
    Length:1,010
    Mass (Da):107,503
    Last modified:July 27, 2011 - v3
    Checksum:i894D7D07D3C258B2
    GO
    Isoform Short (identifier: Q64737-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         434-1010: Missing.

    Show »
    Length:433
    Mass (Da):45,698
    Checksum:iC6B2789DB78932D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411C → G in AAA19012. (PubMed:8299947)Curated
    Sequence conflicti41 – 411C → G in AAA19013. (PubMed:8299947)Curated
    Sequence conflicti41 – 411C → G in AAC53250. (PubMed:7829519)Curated
    Sequence conflicti41 – 411C → G in AAC53251. (PubMed:7829519)Curated
    Sequence conflicti318 – 3181D → G in AAC53250. (PubMed:7829519)Curated
    Sequence conflicti318 – 3181D → G in AAC53251. (PubMed:7829519)Curated
    Sequence conflicti563 – 5631G → A in AAA19013. (PubMed:8299947)Curated
    Sequence conflicti690 – 6901I → T in AAA19013. (PubMed:8299947)Curated
    Sequence conflicti868 – 8681Y → S in AAA19013. (PubMed:8299947)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei434 – 1010577Missing in isoform Short. 1 PublicationVSP_005518Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01023 mRNA. Translation: AAA19012.1.
    U01024 mRNA. Translation: AAA19013.1.
    U20886
    , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883 Genomic DNA. Translation: AAC53250.1.
    U20892
    , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883, U20886, U20884, U20887, U20885, U20889, U20890, U20891 Genomic DNA. Translation: AAC53251.1.
    AK168501 mRNA. Translation: BAE40386.1.
    AK168724 mRNA. Translation: BAE40565.1.
    AK168796 mRNA. Translation: BAE40629.1.
    AK168864 mRNA. Translation: BAE40683.1.
    AK168876 mRNA. Translation: BAE40694.1.
    CH466602 Genomic DNA. Translation: EDL03819.1.
    BC070465 mRNA. Translation: AAH70465.1.
    CCDSiCCDS28329.1. [Q64737-1]
    PIRiI67805.
    RefSeqiNP_034386.2. NM_010256.2. [Q64737-1]
    XP_006522973.1. XM_006522910.1. [Q64737-1]
    XP_006522974.1. XM_006522911.1. [Q64737-1]
    XP_006522975.1. XM_006522912.1. [Q64737-1]
    UniGeneiMm.4505.

    Genome annotation databases

    EnsembliENSMUST00000023684; ENSMUSP00000023684; ENSMUSG00000022962. [Q64737-1]
    ENSMUST00000120450; ENSMUSP00000114034; ENSMUSG00000022962. [Q64737-2]
    GeneIDi14450.
    KEGGimmu:14450.
    UCSCiuc007zxu.1. mouse. [Q64737-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01023 mRNA. Translation: AAA19012.1 .
    U01024 mRNA. Translation: AAA19013.1 .
    U20886
    , U20875 , U20876 , U20877 , U20879 , U20880 , U20881 , U20882 , U20883 Genomic DNA. Translation: AAC53250.1 .
    U20892
    , U20875 , U20876 , U20877 , U20879 , U20880 , U20881 , U20882 , U20883 , U20886 , U20884 , U20887 , U20885 , U20889 , U20890 , U20891 Genomic DNA. Translation: AAC53251.1 .
    AK168501 mRNA. Translation: BAE40386.1 .
    AK168724 mRNA. Translation: BAE40565.1 .
    AK168796 mRNA. Translation: BAE40629.1 .
    AK168864 mRNA. Translation: BAE40683.1 .
    AK168876 mRNA. Translation: BAE40694.1 .
    CH466602 Genomic DNA. Translation: EDL03819.1 .
    BC070465 mRNA. Translation: AAH70465.1 .
    CCDSi CCDS28329.1. [Q64737-1 ]
    PIRi I67805.
    RefSeqi NP_034386.2. NM_010256.2. [Q64737-1 ]
    XP_006522973.1. XM_006522910.1. [Q64737-1 ]
    XP_006522974.1. XM_006522911.1. [Q64737-1 ]
    XP_006522975.1. XM_006522912.1. [Q64737-1 ]
    UniGenei Mm.4505.

    3D structure databases

    ProteinModelPortali Q64737.
    SMRi Q64737. Positions 1-430, 475-785, 808-1006.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199831. 1 interaction.
    IntActi Q64737. 1 interaction.
    MINTi MINT-1852011.

    Chemistry

    BindingDBi Q64737.
    ChEMBLi CHEMBL3690.
    GuidetoPHARMACOLOGYi 2612.

    PTM databases

    PhosphoSitei Q64737.

    Proteomic databases

    MaxQBi Q64737.
    PaxDbi Q64737.
    PRIDEi Q64737.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023684 ; ENSMUSP00000023684 ; ENSMUSG00000022962 . [Q64737-1 ]
    ENSMUST00000120450 ; ENSMUSP00000114034 ; ENSMUSG00000022962 . [Q64737-2 ]
    GeneIDi 14450.
    KEGGi mmu:14450.
    UCSCi uc007zxu.1. mouse. [Q64737-1 ]

    Organism-specific databases

    CTDi 2618.
    MGIi MGI:95654. Gart.

    Phylogenomic databases

    eggNOGi COG0151.
    GeneTreei ENSGT00390000000292.
    HOGENOMi HOG000030315.
    HOVERGENi HBG008333.
    InParanoidi Q3TGI3.
    KOi K11787.
    OMAi TARYESF.
    OrthoDBi EOG7RBZ7H.
    TreeFami TF106368.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00125 .
    UPA00074 ; UER00126 .
    UPA00074 ; UER00129 .
    SABIO-RK Q64737.

    Miscellaneous databases

    ChiTaRSi GART. mouse.
    NextBioi 286065.
    PROi Q64737.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64737.
    Bgeei Q64737.
    CleanExi MM_GART.
    Genevestigatori Q64737.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.170. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00138. GARS.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR002376. Formyl_transf_N.
    IPR001555. GART_AS.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    IPR004607. PurN_trans.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00877. purD. 1 hit.
    TIGR00878. purM. 1 hit.
    TIGR00639. PurN. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    PS00373. GART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase."
      Kan J.L., Jannatipour M., Taylor S.M., Moran R.G.
      Gene 137:195-202(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: C57BL/6 X CBA.
      Tissue: Spleen.
    2. "Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage."
      Kan J.L., Moran R.G.
      J. Biol. Chem. 270:1823-1832(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney, Liver and Stomach.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiPUR2_MOUSE
    AccessioniPrimary (citable) accession number: Q64737
    Secondary accession number(s): Q3TGI3, Q6NS48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3