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Protein

Complement component receptor 1-like protein

Gene

Cr1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.5 Publications

GO - Biological processi

  • complement activation, classical pathway Source: UniProtKB-KW
  • female pregnancy Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • in utero embryonic development Source: MGI
  • negative regulation of complement activation Source: MGI
  • regulation of complement activation Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processComplement pathway, Immunity, Innate immunity, Pregnancy

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component receptor 1-like protein
Alternative name(s):
Complement regulatory protein Crry
Protein p65
Gene namesi
Name:Cr1l
Synonyms:Crry, Cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88513 Cr1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 405ExtracellularSequence analysisAdd BLAST365
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 483CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Death between 9.5 and 13.5 dpc from developmental arrest.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000023897841 – 483Complement component receptor 1-like proteinAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 128PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 187PROSITE-ProRule annotation
Disulfide bondi173 ↔ 203PROSITE-ProRule annotation
Disulfide bondi208 ↔ 257PROSITE-ProRule annotation
Disulfide bondi237 ↔ 274PROSITE-ProRule annotation
Disulfide bondi280 ↔ 323PROSITE-ProRule annotation
Disulfide bondi309 ↔ 336PROSITE-ProRule annotation
Disulfide bondi342 ↔ 385PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi371 ↔ 398PROSITE-ProRule annotation
Modified residuei454PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei463PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiQ64735
PRIDEiQ64735

PTM databases

iPTMnetiQ64735
PhosphoSitePlusiQ64735

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level).2 Publications

Developmental stagei

Highly expressed in trophoblasts at 7.5 dpc, and in the maternally derived decidual tissues until 16 dpc. Expressed only at low levels in the embryo itself.1 Publication

Gene expression databases

BgeeiENSMUSG00000016481
CleanExiMM_CR1L
ExpressionAtlasiQ64735 baseline and differential
GenevisibleiQ64735 MM

Interactioni

Subunit structurei

Interacts with C3b.By similarity

Protein-protein interaction databases

IntActiQ64735, 1 interactor
MINTiQ64735

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NTLX-ray30.00A/B83-401[»]
ProteinModelPortaliQ64735
SMRiQ64735
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ64735

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 143Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini144 – 205Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini206 – 276Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini278 – 338Sushi 4PROSITE-ProRule annotationAdd BLAST61
Domaini340 – 400Sushi 5PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118803
HOVERGENiHBG081346
InParanoidiQ64735
KOiK04005
OMAiRITYACG
OrthoDBiEOG091G0A1X
PhylomeDBiQ64735
TreeFamiTF334137

Family and domain databases

CDDicd00033 CCP, 5 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SUPFAMiSSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q64735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVSSRSSEP LDPVWLLVAF GRGGVKLEVL LLFLLPFTLG ELRGGLGKHG
60 70 80 90 100
HTVHREPAVN RLCADSKRWS GLPVSAQRPF PMGHCPAPSQ LPSAKPINLT
110 120 130 140 150
DESMFPIGTY LLYECLPGYI KRQFSITCKQ DSTWTSAEDK CIRKQCKTPS
160 170 180 190 200
DPENGLVHVH TGIQFGSRIN YTCNQGYRLI GSSSAVCVIT DQSVDWDTEA
210 220 230 240 250
PICEWIPCEI PPGIPNGDFF SSTREDFHYG MVVTYRCNTD ARGKALFNLV
260 270 280 290 300
GEPSLYCTSN DGEIGVWSGP PPQCIELNKC TPPPYVENAV MLSENRSLFS
310 320 330 340 350
LRDIVEFRCH PGFIMKGASS VHCQSLNKWE PELPSCFKGV ICRLPQEMSG
360 370 380 390 400
FQKGLGMKKE YYYGENVTLE CEDGYTLEGS SQSQCQSDGS WNPLLAKCVS
410 420 430 440 450
RSISGLIVGI FIGIIVFILV IIVFIWMILK YKKRNTTDEK YKEVGIHLNY
460 470 480
KEDSCVRLQS LLTSQENSST TSPARNSLTQ EVS
Length:483
Mass (Da):53,763
Last modified:November 1, 1996 - v1
Checksum:i259BFFED4CE547C1
GO
Isoform 2 (identifier: Q64735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-82: Missing.

Show »
Length:440
Mass (Da):49,074
Checksum:iA1826E2975E1242B
GO

Sequence cautioni

The sequence AAA37477 differs from that shown. Reason: Frameshift at position 200.Curated
The sequence BAC25098 differs from that shown. Reason: Frameshift at position 152.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21G → A in AAA37477 (PubMed:2911011).Curated1
Sequence conflicti28E → A in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti64 – 67ADSK → GRLQ in BAE35790 (PubMed:16141072).Curated4
Sequence conflicti67Missing in AC139206 (PubMed:19468303).Curated1
Sequence conflicti112L → M in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti164Q → E in AAA37477 (PubMed:2911011).Curated1
Sequence conflicti182S → P in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti240D → N in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti435 – 437NTT → TRF in BAE35790 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01905040 – 82Missing in isoform 2. 3 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA Translation: AAA37467.1
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA Translation: AAA37468.1
AK004825 mRNA Translation: BAC25098.1 Frameshift.
AK160440 mRNA Translation: BAE35790.1
AC139206 Genomic DNA No translation available.
BC028945 mRNA Translation: AAH28945.1
BC092048 mRNA Translation: AAH92048.1
M23529 mRNA Translation: AAA37477.1 Frameshift.
M23446 mRNA Translation: AAA37478.1
CCDSiCCDS15641.1 [Q64735-2]
PIRiA43519
B30550
I55975
RefSeqiNP_038527.2, NM_013499.2 [Q64735-2]
UniGeneiMm.301652

Genome annotation databases

EnsembliENSMUST00000075451; ENSMUSP00000074902; ENSMUSG00000016481 [Q64735-2]
GeneIDi12946
KEGGimmu:12946
UCSCiuc007eeu.1 mouse [Q64735-1]
uc007eev.1 mouse [Q64735-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCR1L_MOUSE
AccessioniPrimary (citable) accession number: Q64735
Secondary accession number(s): E9QL18
, Q3TV30, Q58E68, Q61447, Q61449, Q8CF59, Q8K328
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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