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Protein

Complement component receptor 1-like protein

Gene

Cr1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.5 Publications

GO - Biological processi

  • complement activation, classical pathway Source: UniProtKB-KW
  • electron transport chain Source: InterPro
  • female pregnancy Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • in utero embryonic development Source: MGI
  • negative regulation of complement activation Source: MGI
  • regulation of complement activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity, Pregnancy

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component receptor 1-like protein
Alternative name(s):
Complement regulatory protein Crry
Protein p65
Gene namesi
Name:Cr1l
Synonyms:Crry, Cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88513. Cr1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 405ExtracellularSequence analysisAdd BLAST365
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 483CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Death between 9.5 and 13.5 dpc from developmental arrest.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000023897841 – 483Complement component receptor 1-like proteinAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 128PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 187PROSITE-ProRule annotation
Disulfide bondi173 ↔ 203PROSITE-ProRule annotation
Disulfide bondi208 ↔ 257PROSITE-ProRule annotation
Disulfide bondi237 ↔ 274PROSITE-ProRule annotation
Disulfide bondi280 ↔ 323PROSITE-ProRule annotation
Disulfide bondi309 ↔ 336PROSITE-ProRule annotation
Disulfide bondi342 ↔ 385PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi371 ↔ 398PROSITE-ProRule annotation
Modified residuei454PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei463PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiQ64735.
PRIDEiQ64735.

PTM databases

iPTMnetiQ64735.
PhosphoSitePlusiQ64735.

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level).2 Publications

Developmental stagei

Highly expressed in trophoblasts at 7.5 dpc, and in the maternally derived decidual tissues until 16 dpc. Expressed only at low levels in the embryo itself.1 Publication

Gene expression databases

BgeeiENSMUSG00000016481.
CleanExiMM_CR1L.
ExpressionAtlasiQ64735. baseline and differential.
GenevisibleiQ64735. MM.

Interactioni

Subunit structurei

Interacts with C3b.By similarity

Protein-protein interaction databases

IntActiQ64735. 1 interactor.
MINTiMINT-4117560.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NTLX-ray30.00A/B83-401[»]
ProteinModelPortaliQ64735.
SMRiQ64735.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ64735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 143Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini144 – 205Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini206 – 276Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini278 – 338Sushi 4PROSITE-ProRule annotationAdd BLAST61
Domaini340 – 400Sushi 5PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 5 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOVERGENiHBG081346.
InParanoidiQ64735.
KOiK04005.
OMAiSAPEISH.
OrthoDBiEOG091G0A1X.
PhylomeDBiQ64735.
TreeFamiTF334137.

Family and domain databases

CDDicd00033. CCP. 5 hits.
Gene3Di1.10.287.90. 1 hit.
InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 5 hits.
[Graphical view]
SMARTiSM00032. CCP. 5 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q64735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVSSRSSEP LDPVWLLVAF GRGGVKLEVL LLFLLPFTLG ELRGGLGKHG
60 70 80 90 100
HTVHREPAVN RLCADSKRWS GLPVSAQRPF PMGHCPAPSQ LPSAKPINLT
110 120 130 140 150
DESMFPIGTY LLYECLPGYI KRQFSITCKQ DSTWTSAEDK CIRKQCKTPS
160 170 180 190 200
DPENGLVHVH TGIQFGSRIN YTCNQGYRLI GSSSAVCVIT DQSVDWDTEA
210 220 230 240 250
PICEWIPCEI PPGIPNGDFF SSTREDFHYG MVVTYRCNTD ARGKALFNLV
260 270 280 290 300
GEPSLYCTSN DGEIGVWSGP PPQCIELNKC TPPPYVENAV MLSENRSLFS
310 320 330 340 350
LRDIVEFRCH PGFIMKGASS VHCQSLNKWE PELPSCFKGV ICRLPQEMSG
360 370 380 390 400
FQKGLGMKKE YYYGENVTLE CEDGYTLEGS SQSQCQSDGS WNPLLAKCVS
410 420 430 440 450
RSISGLIVGI FIGIIVFILV IIVFIWMILK YKKRNTTDEK YKEVGIHLNY
460 470 480
KEDSCVRLQS LLTSQENSST TSPARNSLTQ EVS
Length:483
Mass (Da):53,763
Last modified:November 1, 1996 - v1
Checksum:i259BFFED4CE547C1
GO
Isoform 2 (identifier: Q64735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-82: Missing.

Show »
Length:440
Mass (Da):49,074
Checksum:iA1826E2975E1242B
GO

Sequence cautioni

The sequence AAA37477 differs from that shown. Reason: Frameshift at position 200.Curated
The sequence BAC25098 differs from that shown. Reason: Frameshift at position 152.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21G → A in AAA37477 (PubMed:2911011).Curated1
Sequence conflicti28E → A in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti64 – 67ADSK → GRLQ in BAE35790 (PubMed:16141072).Curated4
Sequence conflicti67Missing in AC139206 (PubMed:19468303).Curated1
Sequence conflicti112L → M in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti164Q → E in AAA37477 (PubMed:2911011).Curated1
Sequence conflicti182S → P in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti240D → N in AAH92048 (PubMed:15489334).Curated1
Sequence conflicti435 – 437NTT → TRF in BAE35790 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01905040 – 82Missing in isoform 2. 3 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA. Translation: AAA37467.1.
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA. Translation: AAA37468.1.
AK004825 mRNA. Translation: BAC25098.1. Frameshift.
AK160440 mRNA. Translation: BAE35790.1.
AC139206 Genomic DNA. No translation available.
BC028945 mRNA. Translation: AAH28945.1.
BC092048 mRNA. Translation: AAH92048.1.
M23529 mRNA. Translation: AAA37477.1. Frameshift.
M23446 mRNA. Translation: AAA37478.1.
CCDSiCCDS15641.1. [Q64735-2]
PIRiA43519.
B30550.
I55975.
RefSeqiNP_038527.2. NM_013499.2. [Q64735-2]
UniGeneiMm.301652.

Genome annotation databases

EnsembliENSMUST00000075451; ENSMUSP00000074902; ENSMUSG00000016481. [Q64735-2]
GeneIDi12946.
KEGGimmu:12946.
UCSCiuc007eeu.1. mouse. [Q64735-1]
uc007eev.1. mouse. [Q64735-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA. Translation: AAA37467.1.
M34173
, M34164, M34165, M34166, M34167, M34168, M34169, M34170, M34171, M34172 Genomic DNA. Translation: AAA37468.1.
AK004825 mRNA. Translation: BAC25098.1. Frameshift.
AK160440 mRNA. Translation: BAE35790.1.
AC139206 Genomic DNA. No translation available.
BC028945 mRNA. Translation: AAH28945.1.
BC092048 mRNA. Translation: AAH92048.1.
M23529 mRNA. Translation: AAA37477.1. Frameshift.
M23446 mRNA. Translation: AAA37478.1.
CCDSiCCDS15641.1. [Q64735-2]
PIRiA43519.
B30550.
I55975.
RefSeqiNP_038527.2. NM_013499.2. [Q64735-2]
UniGeneiMm.301652.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NTLX-ray30.00A/B83-401[»]
ProteinModelPortaliQ64735.
SMRiQ64735.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64735. 1 interactor.
MINTiMINT-4117560.

PTM databases

iPTMnetiQ64735.
PhosphoSitePlusiQ64735.

Proteomic databases

PeptideAtlasiQ64735.
PRIDEiQ64735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075451; ENSMUSP00000074902; ENSMUSG00000016481. [Q64735-2]
GeneIDi12946.
KEGGimmu:12946.
UCSCiuc007eeu.1. mouse. [Q64735-1]
uc007eev.1. mouse. [Q64735-2]

Organism-specific databases

CTDi1379.
MGIiMGI:88513. Cr1l.

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOVERGENiHBG081346.
InParanoidiQ64735.
KOiK04005.
OMAiSAPEISH.
OrthoDBiEOG091G0A1X.
PhylomeDBiQ64735.
TreeFamiTF334137.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

EvolutionaryTraceiQ64735.
PROiQ64735.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016481.
CleanExiMM_CR1L.
ExpressionAtlasiQ64735. baseline and differential.
GenevisibleiQ64735. MM.

Family and domain databases

CDDicd00033. CCP. 5 hits.
Gene3Di1.10.287.90. 1 hit.
InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 5 hits.
[Graphical view]
SMARTiSM00032. CCP. 5 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCR1L_MOUSE
AccessioniPrimary (citable) accession number: Q64735
Secondary accession number(s): E9QL18
, Q3TV30, Q58E68, Q61447, Q61449, Q8CF59, Q8K328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.