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Protein

Forkhead box protein B2

Gene

Foxb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 10392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B2
Alternative name(s):
Transcription factor FKH-4
Gene namesi
Name:Foxb2
Synonyms:Fkh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1347468. Foxb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Forkhead box protein B2PRO_0000091805Add
BLAST

Proteomic databases

PaxDbiQ64733.
PRIDEiQ64733.

Expressioni

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiQ64733.
CleanExiMM_FOXB2.
ExpressionAtlasiQ64733. baseline.
GenevisibleiQ64733. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072687.

Structurei

3D structure databases

ProteinModelPortaliQ64733.
SMRiQ64733. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi139 – 15315Poly-HisAdd
BLAST
Compositional biasi156 – 1627Poly-His
Compositional biasi163 – 17210Poly-Pro
Compositional biasi217 – 23115Poly-AlaAdd
BLAST
Compositional biasi249 – 25810Poly-Ala
Compositional biasi321 – 33010Poly-Ala
Compositional biasi396 – 3994Poly-Ala

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ64733.
KOiK09395.
OMAiCHSASQS.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ64733.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY
60 70 80 90 100
REHTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLRADHAHLH SGSSKGAPGT GPGGHLHPHH PHHAHHHHHH
160 170 180 190 200
HHHAAHHHHH HHPPQPPPPP PPHMVPYFHQ QPAPAPQPPH LPSQPAQQPQ
210 220 230 240 250
PQSQPPQTSH PGKMQEAAAV AAAAAAAAAA AVGSVGRLSQ FPPYGLGSAA
260 270 280 290 300
AAAAAAAAST TGFKHPFAIE NIIGRDYKGV LQAGGLPLAS VMHHLGYPVP
310 320 330 340 350
GQLSNVVGSV WPHVGVMDSV AAAAAAAAAA GVPVGPEYGA FGVPVKALCH
360 370 380 390 400
SANQSLPAVP VPIKPTPALP PVTTLPPALS VPTASQQLPA PSTVCAAAAS
410 420
PTAPLLEPTA AGRADSKGSS LHSVLVHS
Length:428
Mass (Da):45,170
Last modified:November 1, 1997 - v1
Checksum:iDB8A8EFD1E94AB10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92591 mRNA. Translation: CAA63335.1.
X71942 Genomic DNA. Translation: CAA50744.1.
CCDSiCCDS29686.1.
PIRiD47746.
RefSeqiNP_032049.1. NM_008023.1.
UniGeneiMm.7971.

Genome annotation databases

EnsembliENSMUST00000072915; ENSMUSP00000072687; ENSMUSG00000056829.
GeneIDi14240.
KEGGimmu:14240.
UCSCiuc008gxc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92591 mRNA. Translation: CAA63335.1.
X71942 Genomic DNA. Translation: CAA50744.1.
CCDSiCCDS29686.1.
PIRiD47746.
RefSeqiNP_032049.1. NM_008023.1.
UniGeneiMm.7971.

3D structure databases

ProteinModelPortaliQ64733.
SMRiQ64733. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072687.

Proteomic databases

PaxDbiQ64733.
PRIDEiQ64733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072915; ENSMUSP00000072687; ENSMUSG00000056829.
GeneIDi14240.
KEGGimmu:14240.
UCSCiuc008gxc.1. mouse.

Organism-specific databases

CTDi442425.
MGIiMGI:1347468. Foxb2.

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ64733.
KOiK09395.
OMAiCHSASQS.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ64733.
TreeFamiTF316127.

Miscellaneous databases

PROiQ64733.
SOURCEiSearch...

Gene expression databases

BgeeiQ64733.
CleanExiMM_FOXB2.
ExpressionAtlasiQ64733. baseline.
GenevisibleiQ64733. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system."
    Kaestner K.H., Schuetz G., Monaghan A.P.
    Mech. Dev. 55:221-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Six members of the mouse forkhead gene family are developmentally regulated."
    Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
    Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-114, DEVELOPMENTAL STAGE.
    Strain: 129.

Entry informationi

Entry nameiFOXB2_MOUSE
AccessioniPrimary (citable) accession number: Q64733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.