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Protein

Forkhead box protein B1

Gene

Foxb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 10392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • axon target recognition Source: UniProtKB
  • cell migration in diencephalon Source: UniProtKB
  • epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
  • floor plate development Source: UniProtKB
  • hypothalamus cell migration Source: UniProtKB
  • inferior colliculus development Source: UniProtKB
  • lactation Source: UniProtKB
  • mammary gland lobule development Source: UniProtKB
  • mammillary body development Source: UniProtKB
  • mammillothalamic axonal tract development Source: UniProtKB
  • midbrain development Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • somitogenesis Source: UniProtKB
  • spinal cord development Source: UniProtKB
  • telencephalon cell migration Source: UniProtKB
  • thalamus development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • urogenital system development Source: UniProtKB
  • visual learning Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:Foxb1
Synonyms:Fkh5, Foxb1a, Foxb1b, Mf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1927549. Foxb1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Forkhead box protein B1PRO_0000091804Add
BLAST

Proteomic databases

PaxDbiQ64732.
PRIDEiQ64732.

PTM databases

PhosphoSiteiQ64732.

Expressioni

Gene expression databases

BgeeiQ64732.
CleanExiMM_FOXB1.
GenevisibleiQ64732. MM.

Interactioni

Protein-protein interaction databases

BioGridi211052. 1 interaction.
STRINGi10090.ENSMUSP00000096197.

Structurei

3D structure databases

ProteinModelPortaliQ64732.
SMRiQ64732. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ64732.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ64732.
TreeFamiTF350628.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM
160 170 180 190 200
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL
210 220 230 240 250
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMTSGDYSA YGVPLKPLCH
260 270 280 290 300
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
310 320
SQSSPATPSE TLTSPASALH SVAVH
Length:325
Mass (Da):35,008
Last modified:June 20, 2002 - v2
Checksum:iE7456B02F48D2DF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 686HNLSFN → PLTVRH in AAD12223 (PubMed:8306889).Curated
Sequence conflicti125 – 1251Missing in CAA63336 (PubMed:8861101).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92592 mRNA. Translation: CAA63336.1.
U90538 mRNA. Translation: AAB57686.1.
BC111908 mRNA. Translation: AAI11909.1.
U04198 mRNA. Translation: AAD12223.1.
X71943 Genomic DNA. Translation: CAA50745.1.
CCDSiCCDS40677.1.
PIRiE47746.
RefSeqiNP_071773.2. NM_022378.3.
UniGeneiMm.440890.

Genome annotation databases

EnsembliENSMUST00000071281; ENSMUSP00000096197; ENSMUSG00000059246.
GeneIDi64290.
KEGGimmu:64290.
UCSCiuc012gwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92592 mRNA. Translation: CAA63336.1.
U90538 mRNA. Translation: AAB57686.1.
BC111908 mRNA. Translation: AAI11909.1.
U04198 mRNA. Translation: AAD12223.1.
X71943 Genomic DNA. Translation: CAA50745.1.
CCDSiCCDS40677.1.
PIRiE47746.
RefSeqiNP_071773.2. NM_022378.3.
UniGeneiMm.440890.

3D structure databases

ProteinModelPortaliQ64732.
SMRiQ64732. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211052. 1 interaction.
STRINGi10090.ENSMUSP00000096197.

PTM databases

PhosphoSiteiQ64732.

Proteomic databases

PaxDbiQ64732.
PRIDEiQ64732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071281; ENSMUSP00000096197; ENSMUSG00000059246.
GeneIDi64290.
KEGGimmu:64290.
UCSCiuc012gwj.1. mouse.

Organism-specific databases

CTDi27023.
MGIiMGI:1927549. Foxb1.

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ64732.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ64732.
TreeFamiTF350628.

Miscellaneous databases

NextBioi319993.
PROiQ64732.
SOURCEiSearch...

Gene expression databases

BgeeiQ64732.
CleanExiMM_FOXB1.
GenevisibleiQ64732. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system."
    Kaestner K.H., Schuetz G., Monaghan A.P.
    Mech. Dev. 55:221-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A winged helix gene expressed in thymocytes."
    Li S.C., Lai E.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymocyte.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins."
    Ang S.-L., Wierda A., Wong D., Stevens K.A., Cascio S., Rossant J., Zaret K.S.
    Development 119:1301-1315(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-68.
  5. "Six members of the mouse forkhead gene family are developmentally regulated."
    Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
    Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-114.
    Strain: 129.

Entry informationi

Entry nameiFOXB1_MOUSE
AccessioniPrimary (citable) accession number: Q64732
Secondary accession number(s): O08753, Q2M2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2002
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.