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Protein

Forkhead box protein L1

Gene

Foxl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 13992Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • heart development Source: MGI
  • Peyer's patch morphogenesis Source: MGI
  • proteoglycan biosynthetic process Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of Wnt signaling pathway Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • visceral mesoderm-endoderm interaction involved in midgut development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein L1
Alternative name(s):
Forkhead-related protein FKHL11
Transcription factor FKH-6
Gene namesi
Name:Foxl1
Synonyms:Fkh6, Fkhl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347469. Foxl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Deficient mice show postnatal growth retardation secondary to severe structural abnormalities of the stomach, duodenum, jejunum and decreased intestinal uptake of D-glucose and levels of the intestinal D-glucose transporter Slc5a1.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Forkhead box protein L1PRO_0000091860Add
BLAST

Proteomic databases

PaxDbiQ64731.
PRIDEiQ64731.

PTM databases

iPTMnetiQ64731.

Expressioni

Gene expression databases

CleanExiMM_FOXL1.
GenevisibleiQ64731. MM.

Interactioni

Protein-protein interaction databases

BioGridi199698. 1 interaction.
IntActiQ64731. 1 interaction.
STRINGi10090.ENSMUSP00000137732.

Structurei

3D structure databases

ProteinModelPortaliQ64731.
SMRiQ64731. Positions 49-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOVERGENiHBG051650.
InParanoidiQ64731.
KOiK09405.
OMAiLRPPFNA.
OrthoDBiEOG7C8GHD.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLFSPPLA ALAASPLLYV YSPERPGLPL AFAPAAALAG PGRVEPPQKP
60 70 80 90 100
PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN
110 120 130 140 150
LSLNECFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPAAG
160 170 180 190 200
SPEAKRTRVE PPESEVGCDV GSPDLATALP TRAPDRSQSP AVGTARPALL
210 220 230 240 250
PWPGPEPRDP DADLTVQGAG AVASGQLQRP AHHLGSPLCP APSGSPKGSK
260 270 280 290 300
SKSFSIDSIL AVRPTPASGA EAPGIPKPVP GALGSSLLAA SSGLAPPFNA
310 320 330
SLVFDAHVQG GFSQLGIPFL SYFPLQVPEA TVLRFH
Length:336
Mass (Da):35,793
Last modified:October 3, 2012 - v2
Checksum:i244437F043BA7F43
GO

Sequence cautioni

The sequence CAA63243.1 differs from that shown. Reason: Frameshift at positions 230 and 262. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → LV in CAA50746 (Ref. 2) Curated
Sequence conflicti175 – 1751L → LV in CAA63243 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92498 Genomic DNA. Translation: CAA63243.1. Frameshift.
CH466525 Genomic DNA. Translation: EDL11654.1.
BC137805 mRNA. Translation: AAI37806.1.
BC137806 mRNA. Translation: AAI37807.1.
X71944 Genomic DNA. Translation: CAA50746.1.
CCDSiCCDS59744.1.
PIRiF47746.
RefSeqiNP_032050.2. NM_008024.2.
UniGeneiMm.5111.

Genome annotation databases

EnsembliENSMUST00000181609; ENSMUSP00000137732; ENSMUSG00000097084.
GeneIDi14241.
KEGGimmu:14241.
UCSCiuc009nrs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92498 Genomic DNA. Translation: CAA63243.1. Frameshift.
CH466525 Genomic DNA. Translation: EDL11654.1.
BC137805 mRNA. Translation: AAI37806.1.
BC137806 mRNA. Translation: AAI37807.1.
X71944 Genomic DNA. Translation: CAA50746.1.
CCDSiCCDS59744.1.
PIRiF47746.
RefSeqiNP_032050.2. NM_008024.2.
UniGeneiMm.5111.

3D structure databases

ProteinModelPortaliQ64731.
SMRiQ64731. Positions 49-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199698. 1 interaction.
IntActiQ64731. 1 interaction.
STRINGi10090.ENSMUSP00000137732.

PTM databases

iPTMnetiQ64731.

Proteomic databases

PaxDbiQ64731.
PRIDEiQ64731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000181609; ENSMUSP00000137732; ENSMUSG00000097084.
GeneIDi14241.
KEGGimmu:14241.
UCSCiuc009nrs.1. mouse.

Organism-specific databases

CTDi2300.
MGIiMGI:1347469. Foxl1.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOVERGENiHBG051650.
InParanoidiQ64731.
KOiK09405.
OMAiLRPPFNA.
OrthoDBiEOG7C8GHD.

Miscellaneous databases

PROiQ64731.
SOURCEiSearch...

Gene expression databases

CleanExiMM_FOXL1.
GenevisibleiQ64731. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development."
    Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A., Lichter P., Schuetz G.
    Development 122:1751-1758(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Six members of the mouse forkhead gene family are developmentally regulated."
    Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
    Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-150.
    Strain: 129.
  5. "The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation."
    Kaestner K.H., Silberg D.G., Traber P.G., Schutz G.
    Genes Dev. 11:1583-1595(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. "Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake."
    Katz J.P., Perreault N., Goldstein B.G., Chao H.H., Ferraris R.P., Kaestner K.H.
    Am. J. Physiol. 287:G856-G864(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine."
    Madison B.B., McKenna L.B., Dolson D., Epstein D.J., Kaestner K.H.
    J. Biol. Chem. 284:5936-5944(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFOXL1_MOUSE
AccessioniPrimary (citable) accession number: Q64731
Secondary accession number(s): B2RQ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.