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Protein

Zinc-alpha-2-glycoprotein

Gene

Azgp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-alpha-2-glycoprotein
Short name:
Zn-alpha-2-GP
Short name:
Zn-alpha-2-glycoprotein
Gene namesi
Name:Azgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103163. Azgp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 307290Zinc-alpha-2-glycoproteinPRO_0000019013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Pyrrolidone carboxylic acidBy similarity
Disulfide bondi118 ↔ 181PROSITE-ProRule annotation
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)1 Publication
Disulfide bondi220 ↔ 275PROSITE-ProRule annotation
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiQ64726.
PaxDbiQ64726.
PeptideAtlasiQ64726.
PRIDEiQ64726.

PTM databases

iPTMnetiQ64726.
PhosphoSiteiQ64726.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037053.
CleanExiMM_AZGP1.
ExpressionAtlasiQ64726. baseline and differential.
GenevisibleiQ64726. MM.

Interactioni

Subunit structurei

Interacts with PIP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038559.

Structurei

3D structure databases

ProteinModelPortaliQ64726.
SMRiQ64726. Positions 21-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 28786Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9FR. Eukaryota.
ENOG4111CJX. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ64726.
OMAiIFMVTLK.
OrthoDBiEOG091G0K1X.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVLLSLPL LLGPAVFQET GSYYLTFLYT GLSRPSKGFP RFQATAFLND
60 70 80 90 100
QAFFHYNSNS GKAEPVGPWS QVEGMEDWEK ESQLQRAREE IFLVTLKDIM
110 120 130 140 150
DYYKDTTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI
160 170 180 190 200
PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPEMLKRYLN YSRSHLDRID
210 220 230 240 250
PPTVTITSRV IPGGNRIFKC LAYGFYPQRI SLHWNKANKK LAFEPERGVF
260 270 280 290 300
PNGNGTYLSW AEVEVSPQDI DPFFCLIDHR GFSQSLSVQW DRTRKVKDEN

NVVAQPQ
Length:307
Mass (Da):35,332
Last modified:July 27, 2011 - v2
Checksum:iA116304EFE10F814
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241Y → S in BAB23777 (PubMed:7852290).Curated
Sequence conflicti24 – 241Y → S in AAH61646 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21059 mRNA. Translation: BAA04638.1.
AF281658 Genomic DNA. Translation: AAQ14325.1.
AY248694 mRNA. Translation: AAO93093.1.
AK005051 mRNA. Translation: BAB23777.1.
BC061646 mRNA. Translation: AAH61646.1.
D44593 Genomic DNA. Translation: BAA07996.1.
CCDSiCCDS19783.1.
PIRiJX0352.
RefSeqiNP_038506.2. NM_013478.2.
UniGeneiMm.30061.

Genome annotation databases

EnsembliENSMUST00000035390; ENSMUSP00000038559; ENSMUSG00000037053.
GeneIDi12007.
KEGGimmu:12007.
UCSCiuc009aeh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21059 mRNA. Translation: BAA04638.1.
AF281658 Genomic DNA. Translation: AAQ14325.1.
AY248694 mRNA. Translation: AAO93093.1.
AK005051 mRNA. Translation: BAB23777.1.
BC061646 mRNA. Translation: AAH61646.1.
D44593 Genomic DNA. Translation: BAA07996.1.
CCDSiCCDS19783.1.
PIRiJX0352.
RefSeqiNP_038506.2. NM_013478.2.
UniGeneiMm.30061.

3D structure databases

ProteinModelPortaliQ64726.
SMRiQ64726. Positions 21-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038559.

PTM databases

iPTMnetiQ64726.
PhosphoSiteiQ64726.

Proteomic databases

MaxQBiQ64726.
PaxDbiQ64726.
PeptideAtlasiQ64726.
PRIDEiQ64726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035390; ENSMUSP00000038559; ENSMUSG00000037053.
GeneIDi12007.
KEGGimmu:12007.
UCSCiuc009aeh.2. mouse.

Organism-specific databases

CTDi563.
MGIiMGI:103163. Azgp1.

Phylogenomic databases

eggNOGiENOG410J9FR. Eukaryota.
ENOG4111CJX. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ64726.
OMAiIFMVTLK.
OrthoDBiEOG091G0K1X.
TreeFamiTF336617.

Enzyme and pathway databases

ReactomeiR-MMU-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiAzgp1. mouse.
PROiQ64726.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037053.
CleanExiMM_AZGP1.
ExpressionAtlasiQ64726. baseline and differential.
GenevisibleiQ64726. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZA2G_MOUSE
AccessioniPrimary (citable) accession number: Q64726
Secondary accession number(s): Q9DBB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.