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Q64705

- USF2_MOUSE

UniProt

Q64705 - USF2_MOUSE

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Protein
Upstream stimulatory factor 2
Gene
Usf2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. double-stranded DNA binding Source: Ensembl
  5. protein binding Source: IntAct

GO - Biological processi

  1. lactation Source: MGI
  2. lipid homeostasis Source: BHF-UCL
  3. positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream stimulatory factor 2
Alternative name(s):
Major late transcription factor 2
Upstream transcription factor 2
Gene namesi
Name:Usf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:99961. Usf2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Upstream stimulatory factor 2
PRO_0000127501Add
BLAST

Proteomic databases

MaxQBiQ64705.
PaxDbiQ64705.
PRIDEiQ64705.

PTM databases

PhosphoSiteiQ64705.

Expressioni

Gene expression databases

ArrayExpressiQ64705.
BgeeiQ64705.
CleanExiMM_USF2.
GenevestigatoriQ64705.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). Interacts with MAF.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat1P422253EBI-647583,EBI-647118

Protein-protein interaction databases

IntActiQ64705. 2 interactions.
STRINGi10090.ENSMUSP00000057569.

Structurei

3D structure databases

ProteinModelPortaliQ64705.
SMRiQ64705. Positions 233-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 29056bHLH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni307 – 32822Leucine-zipper
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 207Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG272240.
GeneTreeiENSGT00390000004498.
HOGENOMiHOG000294174.
HOVERGENiHBG004346.
InParanoidiQ64705.
KOiK09106.
OMAiIPDCNTD.
OrthoDBiEOG7GXPBW.
PhylomeDBiQ64705.
TreeFamiTF323338.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform USF2A (identifier: Q64705-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDMLDPGLDP ASSATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA    50
IASVQQAAFG DHNIQYQFRT ESNGGQVTYR VVQVTDGQLD GQGDAAGAVS 100
VVSTAAFAGG QQAVTQVGVD GAAQRPGPAA ASVPTGPAAP FPLAVIQNPF 150
SNGGSPAAEA VSGEARFAYF PASSVGDTTA VSVQTTDQSL QAGGQFYVMM 200
TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH NEVERRRRDK 250
INNWIVQLSK IIPDCHADNS KTGASKGGIL SKACDYIREL RQTNQRMQET 300
FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GESTRQ 346
Length:346
Mass (Da):36,954
Last modified:November 1, 1996 - v1
Checksum:iE9D216BC25F9447B
GO
Isoform USF2B (identifier: Q64705-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-143: Missing.

Show »
Length:279
Mass (Da):30,595
Checksum:iD9474CE884D8A60B
GO

Sequence cautioni

The sequence AAA20493.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH19729.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 14367Missing in isoform USF2B.
VSP_002166Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2434Missing in CAA54697. 1 Publication
Sequence conflicti326 – 3261A → S in CAA54697. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12283, U12282 Genomic DNA. Translation: AAB60674.1.
U01662 mRNA. Translation: AAA20492.1.
U01663 mRNA. Translation: AAA20493.1. Different initiation.
X77602, X77605 Genomic DNA. Translation: CAA54697.1.
BC019729 mRNA. Translation: AAH19729.1. Different initiation.
BC082995 mRNA. Translation: AAH82995.1.
AK146871 mRNA. Translation: BAE27494.1.
CCDSiCCDS21118.1. [Q64705-1]
PIRiA55111.
RefSeqiNP_035810.1. NM_011680.2. [Q64705-1]
XP_006539796.1. XM_006539733.1. [Q64705-2]
XP_006539797.1. XM_006539734.1.
XP_006539798.1. XM_006539735.1.
UniGeneiMm.322453.

Genome annotation databases

EnsembliENSMUST00000058860; ENSMUSP00000132256; ENSMUSG00000058239. [Q64705-1]
ENSMUST00000108119; ENSMUSP00000132021; ENSMUSG00000058239. [Q64705-2]
GeneIDi22282.
KEGGimmu:22282.
UCSCiuc009ghg.2. mouse. [Q64705-2]
uc009ghh.2. mouse. [Q64705-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12283 , U12282 Genomic DNA. Translation: AAB60674.1 .
U01662 mRNA. Translation: AAA20492.1 .
U01663 mRNA. Translation: AAA20493.1 . Different initiation.
X77602 , X77605 Genomic DNA. Translation: CAA54697.1 .
BC019729 mRNA. Translation: AAH19729.1 . Different initiation.
BC082995 mRNA. Translation: AAH82995.1 .
AK146871 mRNA. Translation: BAE27494.1 .
CCDSi CCDS21118.1. [Q64705-1 ]
PIRi A55111.
RefSeqi NP_035810.1. NM_011680.2. [Q64705-1 ]
XP_006539796.1. XM_006539733.1. [Q64705-2 ]
XP_006539797.1. XM_006539734.1.
XP_006539798.1. XM_006539735.1.
UniGenei Mm.322453.

3D structure databases

ProteinModelPortali Q64705.
SMRi Q64705. Positions 233-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64705. 2 interactions.
STRINGi 10090.ENSMUSP00000057569.

PTM databases

PhosphoSitei Q64705.

Proteomic databases

MaxQBi Q64705.
PaxDbi Q64705.
PRIDEi Q64705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058860 ; ENSMUSP00000132256 ; ENSMUSG00000058239 . [Q64705-1 ]
ENSMUST00000108119 ; ENSMUSP00000132021 ; ENSMUSG00000058239 . [Q64705-2 ]
GeneIDi 22282.
KEGGi mmu:22282.
UCSCi uc009ghg.2. mouse. [Q64705-2 ]
uc009ghh.2. mouse. [Q64705-1 ]

Organism-specific databases

CTDi 7392.
MGIi MGI:99961. Usf2.

Phylogenomic databases

eggNOGi NOG272240.
GeneTreei ENSGT00390000004498.
HOGENOMi HOG000294174.
HOVERGENi HBG004346.
InParanoidi Q64705.
KOi K09106.
OMAi IPDCNTD.
OrthoDBi EOG7GXPBW.
PhylomeDBi Q64705.
TreeFami TF323338.

Miscellaneous databases

NextBioi 302407.
PROi Q64705.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64705.
Bgeei Q64705.
CleanExi MM_USF2.
Genevestigatori Q64705.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Archaic structure of the gene encoding transcription factor USF."
    Lin Q., Luo X., Sawadogo M.
    J. Biol. Chem. 269:23894-23903(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Kidney and Spleen.
  2. "Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells."
    Sirito M., Lin Q., Maity T., Sawadogo M.
    Nucleic Acids Res. 22:427-433(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS USF2A AND USF2B).
  3. "Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse."
    Henrion A.A., Martinez A., Mattei M.-G., Kahn A., Raymondjean M.
    Genomics 25:36-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM USF2A).
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary tumor.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346 (ISOFORM USF2A).
    Strain: C57BL/6J.
    Tissue: Amnion.
  6. "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity."
    Kurschner C., Morgan J.I.
    Biochem. Biophys. Res. Commun. 231:333-339(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAF.

Entry informationi

Entry nameiUSF2_MOUSE
AccessioniPrimary (citable) accession number: Q64705
Secondary accession number(s): Q3UIL2, Q8VE59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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