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Protein

Syntaxin-3

Gene

Stx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103077. Stx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28320Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini284 – 2896ExtracellularSequence Analysis

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • azurophil granule Source: MGI
  • cell-cell junction Source: MGI
  • dendrite Source: MGI
  • extracellular exosome Source: MGI
  • growth cone Source: Ensembl
  • integral component of membrane Source: GO_Central
  • lamellipodium Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: MGI
  • secretory granule Source: MGI
  • SNARE complex Source: GO_Central
  • specific granule Source: MGI
  • synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Syntaxin-3PRO_0000210200Add
BLAST

Proteomic databases

MaxQBiQ64704.
PaxDbiQ64704.
PRIDEiQ64704.

PTM databases

PhosphoSiteiQ64704.

Expressioni

Gene expression databases

BgeeiQ64704.
CleanExiMM_STX3.
ExpressionAtlasiQ64704. baseline and differential.
GenevestigatoriQ64704.

Interactioni

Protein-protein interaction databases

BioGridi203562. 4 interactions.
STRINGi10090.ENSMUSP00000108589.

Structurei

3D structure databases

ProteinModelPortaliQ64704.
SMRiQ64704. Positions 31-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11180Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ64704.
KOiK08486.
PhylomeDBiQ64704.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3A (identifier: Q64704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,243
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFC2049EEE6F
GO
Isoform 3B (identifier: Q64704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LAIILASTIG

Show »
Length:283
Mass (Da):32,564
Checksum:iF0FC71579A5BA16D
GO
Isoform 3C (identifier: Q64704-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:269
Mass (Da):30,934
Checksum:i02EA1FCAE471CB33
GO
Isoform 3D (identifier: Q64704-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-289: Missing.

Show »
Length:86
Mass (Da):10,011
Checksum:i146915A25056201B
GO
Isoform 3D-1 (identifier: Q64704-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT

Show »
Length:289
Mass (Da):33,203
Checksum:i75FDF1D1DEB0A330
GO
Isoform 3D-2 (identifier: Q64704-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPRNPLLSPEIELT

Show »
Length:289
Mass (Da):33,173
Checksum:i0288D183DB90F085
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 7234IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C. 1 PublicationVSP_006341Add
BLAST
Alternative sequencei73 – 8614TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D-1. 1 PublicationVSP_006342Add
BLAST
Alternative sequencei73 – 8614TKDDL…TEIKK → LPRNPLLSPEIELT in isoform 3D-2. 1 PublicationVSP_006343Add
BLAST
Alternative sequencei87 – 289203Missing in isoform 3D. 1 PublicationVSP_006344Add
BLAST
Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIG in isoform 3B. 1 PublicationVSP_006345Add
BLAST
Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3C. 1 PublicationVSP_006346Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1. Different termination.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1. Sequence problems.
CCDSiCCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRiI60170.
I83197.
I83198.
RefSeqiNP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneiMm.272264.

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-3]
GeneIDi20908.
KEGGimmu:20908.
UCSCiuc008gsz.1. mouse. [Q64704-3]
uc008gtb.1. mouse. [Q64704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1. Different termination.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1. Sequence problems.
CCDSiCCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRiI60170.
I83197.
I83198.
RefSeqiNP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneiMm.272264.

3D structure databases

ProteinModelPortaliQ64704.
SMRiQ64704. Positions 31-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203562. 4 interactions.
STRINGi10090.ENSMUSP00000108589.

PTM databases

PhosphoSiteiQ64704.

Proteomic databases

MaxQBiQ64704.
PaxDbiQ64704.
PRIDEiQ64704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-3]
GeneIDi20908.
KEGGimmu:20908.
UCSCiuc008gsz.1. mouse. [Q64704-3]
uc008gtb.1. mouse. [Q64704-1]

Organism-specific databases

CTDi6809.
MGIiMGI:103077. Stx3.

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ64704.
KOiK08486.
PhylomeDBiQ64704.
TreeFamiTF313763.

Miscellaneous databases

ChiTaRSiStx3. mouse.
NextBioi299785.
PROiQ64704.
SOURCEiSearch...

Gene expression databases

BgeeiQ64704.
CleanExiMM_STX3.
ExpressionAtlasiQ64704. baseline and differential.
GenevestigatoriQ64704.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3A; 3B; 3C; 3D; 3D-1 AND 3D-2).
    Strain: ICR.
    Tissue: Brain.

Entry informationi

Entry nameiSTX3_MOUSE
AccessioniPrimary (citable) accession number: Q64704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.