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Q64704 (STX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-3
Gene names
Name:Stx3
Synonyms:Stx3a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processNeurotransmitter transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processexocytosis

Inferred from mutant phenotype PubMed 18505797. Source: MGI

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

long-term synaptic potentiation

Inferred from mutant phenotype PubMed 23395379. Source: MGI

membrane fusion

Inferred from electronic annotation. Source: Ensembl

neuron projection development

Inferred from electronic annotation. Source: Ensembl

neurotransmitter transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentSNARE complex

Inferred from electronic annotation. Source: Ensembl

apical plasma membrane

Inferred from direct assay PubMed 10469351PubMed 18505797. Source: MGI

azurophil granule

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from direct assay PubMed 23395379. Source: MGI

growth cone

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay PubMed 23395379. Source: MGI

secretory granule

Inferred from direct assay PubMed 18321981. Source: MGI

specific granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionarachidonic acid binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 10469351PubMed 18505797PubMed 8774707. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3A (identifier: Q64704-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3B (identifier: Q64704-2)

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LAIILASTIG
Isoform 3C (identifier: Q64704-3)

The sequence of this isoform differs from the canonical sequence as follows:
     39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA
Isoform 3D (identifier: Q64704-4)

The sequence of this isoform differs from the canonical sequence as follows:
     87-289: Missing.
Isoform 3D-1 (identifier: Q64704-5)

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT
Isoform 3D-2 (identifier: Q64704-6)

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPRNPLLSPEIELT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Syntaxin-3
PRO_0000210200

Regions

Topological domain1 – 263263Cytoplasmic Potential
Transmembrane264 – 28320Helical; Anchor for type IV membrane protein; Potential
Topological domain284 – 2896Extracellular Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil32 – 11180 Potential

Natural variations

Alternative sequence39 – 7234IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C.
VSP_006341
Alternative sequence73 – 8614TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D-1.
VSP_006342
Alternative sequence73 – 8614TKDDL…TEIKK → LPRNPLLSPEIELT in isoform 3D-2.
VSP_006343
Alternative sequence87 – 289203Missing in isoform 3D.
VSP_006344
Alternative sequence227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIG in isoform 3B.
VSP_006345
Alternative sequence227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3C.
VSP_006346

Sequences

Sequence LengthMass (Da)Tools
Isoform 3A [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4A8EAFC2049EEE6F

FASTA28933,243
        10         20         30         40         50         60 
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 

        70         80         90        100        110        120 
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 

       130        140        150        160        170        180 
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 

       190        200        210        220        230        240 
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 

       250        260        270        280 
DHVEKARDET KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK 

« Hide

Isoform 3B [UniParc].

Checksum: F0FC71579A5BA16D
Show »

FASTA28332,564
Isoform 3C [UniParc].

Checksum: 02EA1FCAE471CB33
Show »

FASTA26930,934
Isoform 3D [UniParc].

Checksum: 146915A25056201B
Show »

FASTA8610,011
Isoform 3D-1 [UniParc].

Checksum: 75FDF1D1DEB0A330
Show »

FASTA28933,203
Isoform 3D-2 [UniParc].

Checksum: 0288D183DB90F085
Show »

FASTA28933,173

References

[1]"Identification of four different forms of syntaxin 3."
Ibaraki K., Horikawa H.P.M., Morita T., Mori H., Sakimura K., Mishina M., Saisu H., Abe T.
Biochem. Biophys. Res. Commun. 211:997-1005(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3A; 3B; 3C; 3D; 3D-1 AND 3D-2).
Strain: ICR.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1. Different termination.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1. Sequence problems.
CCDSCCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRI60170.
I83197.
I83198.
RefSeqNP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneMm.272264.

3D structure databases

ProteinModelPortalQ64704.
SMRQ64704. Positions 31-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203562. 4 interactions.
STRING10090.ENSMUSP00000108589.

PTM databases

PhosphoSiteQ64704.

Proteomic databases

MaxQBQ64704.
PaxDbQ64704.
PRIDEQ64704.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-3]
GeneID20908.
KEGGmmu:20908.
UCSCuc008gsz.1. mouse. [Q64704-3]
uc008gtb.1. mouse. [Q64704-1]

Organism-specific databases

CTD6809.
MGIMGI:103077. Stx3.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00730000110552.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidQ64704.
KOK08486.
PhylomeDBQ64704.
TreeFamTF313763.

Gene expression databases

ArrayExpressQ64704.
BgeeQ64704.
CleanExMM_STX3.
GenevestigatorQ64704.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTX3. mouse.
NextBio299785.
PROQ64704.
SOURCESearch...

Entry information

Entry nameSTX3_MOUSE
AccessionPrimary (citable) accession number: Q64704
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot