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Q64704

- STX3_MOUSE

UniProt

Q64704 - STX3_MOUSE

Protein

Syntaxin-3

Gene

Stx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones.

    GO - Molecular functioni

    1. arachidonic acid binding Source: Ensembl
    2. protein binding Source: MGI

    GO - Biological processi

    1. exocytosis Source: MGI
    2. intracellular protein transport Source: InterPro
    3. long-term synaptic potentiation Source: MGI
    4. membrane fusion Source: Ensembl
    5. neuron projection development Source: Ensembl
    6. neurotransmitter transport Source: UniProtKB-KW

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-3
    Gene namesi
    Name:Stx3
    Synonyms:Stx3a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:103077. Stx3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. azurophil granule Source: Ensembl
    3. cell-cell junction Source: Ensembl
    4. dendrite Source: MGI
    5. growth cone Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. membrane Source: MGI
    8. secretory granule Source: MGI
    9. SNARE complex Source: Ensembl
    10. specific granule Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Syntaxin-3PRO_0000210200Add
    BLAST

    Proteomic databases

    MaxQBiQ64704.
    PaxDbiQ64704.
    PRIDEiQ64704.

    PTM databases

    PhosphoSiteiQ64704.

    Expressioni

    Gene expression databases

    ArrayExpressiQ64704.
    BgeeiQ64704.
    CleanExiMM_STX3.
    GenevestigatoriQ64704.

    Interactioni

    Protein-protein interaction databases

    BioGridi203562. 4 interactions.
    STRINGi10090.ENSMUSP00000108589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64704.
    SMRiQ64704. Positions 31-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 2896ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28320Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 11180Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110552.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiQ64704.
    KOiK08486.
    PhylomeDBiQ64704.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 3A (identifier: Q64704-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS    50
    EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK 100
    HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ 150
    RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD 200
    IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET 250
    KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK 289
    Length:289
    Mass (Da):33,243
    Last modified:November 1, 1996 - v1
    Checksum:i4A8EAFC2049EEE6F
    GO
    Isoform 3B (identifier: Q64704-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LAIILASTIG

    Show »
    Length:283
    Mass (Da):32,564
    Checksum:iF0FC71579A5BA16D
    GO
    Isoform 3C (identifier: Q64704-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
         227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

    Show »
    Length:269
    Mass (Da):30,934
    Checksum:i02EA1FCAE471CB33
    GO
    Isoform 3D (identifier: Q64704-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-289: Missing.

    Show »
    Length:86
    Mass (Da):10,011
    Checksum:i146915A25056201B
    GO
    Isoform 3D-1 (identifier: Q64704-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT

    Show »
    Length:289
    Mass (Da):33,203
    Checksum:i75FDF1D1DEB0A330
    GO
    Isoform 3D-2 (identifier: Q64704-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-86: TKDDLEQLTTEIKK → LPRNPLLSPEIELT

    Show »
    Length:289
    Mass (Da):33,173
    Checksum:i0288D183DB90F085
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 7234IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C. 1 PublicationVSP_006341Add
    BLAST
    Alternative sequencei73 – 8614TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D-1. 1 PublicationVSP_006342Add
    BLAST
    Alternative sequencei73 – 8614TKDDL…TEIKK → LPRNPLLSPEIELT in isoform 3D-2. 1 PublicationVSP_006343Add
    BLAST
    Alternative sequencei87 – 289203Missing in isoform 3D. 1 PublicationVSP_006344Add
    BLAST
    Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIG in isoform 3B. 1 PublicationVSP_006345Add
    BLAST
    Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3C. 1 PublicationVSP_006346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29797 mRNA. Translation: BAA06180.1.
    D29798 mRNA. Translation: BAA06181.1. Different termination.
    D29799 mRNA. Translation: BAA06182.1.
    D29800 mRNA. Translation: BAA06183.1.
    D38375 mRNA. Translation: BAA07454.1. Sequence problems.
    CCDSiCCDS29612.1. [Q64704-3]
    CCDS29613.1. [Q64704-1]
    PIRiI60170.
    I83197.
    I83198.
    RefSeqiNP_035632.1. NM_011502.3. [Q64704-3]
    NP_689344.1. NM_152220.2. [Q64704-1]
    UniGeneiMm.272264.

    Genome annotation databases

    EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
    ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-3]
    GeneIDi20908.
    KEGGimmu:20908.
    UCSCiuc008gsz.1. mouse. [Q64704-3]
    uc008gtb.1. mouse. [Q64704-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29797 mRNA. Translation: BAA06180.1 .
    D29798 mRNA. Translation: BAA06181.1 . Different termination.
    D29799 mRNA. Translation: BAA06182.1 .
    D29800 mRNA. Translation: BAA06183.1 .
    D38375 mRNA. Translation: BAA07454.1 . Sequence problems.
    CCDSi CCDS29612.1. [Q64704-3 ]
    CCDS29613.1. [Q64704-1 ]
    PIRi I60170.
    I83197.
    I83198.
    RefSeqi NP_035632.1. NM_011502.3. [Q64704-3 ]
    NP_689344.1. NM_152220.2. [Q64704-1 ]
    UniGenei Mm.272264.

    3D structure databases

    ProteinModelPortali Q64704.
    SMRi Q64704. Positions 31-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203562. 4 interactions.
    STRINGi 10090.ENSMUSP00000108589.

    PTM databases

    PhosphoSitei Q64704.

    Proteomic databases

    MaxQBi Q64704.
    PaxDbi Q64704.
    PRIDEi Q64704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069285 ; ENSMUSP00000069529 ; ENSMUSG00000041488 . [Q64704-1 ]
    ENSMUST00000075304 ; ENSMUSP00000074776 ; ENSMUSG00000041488 . [Q64704-3 ]
    GeneIDi 20908.
    KEGGi mmu:20908.
    UCSCi uc008gsz.1. mouse. [Q64704-3 ]
    uc008gtb.1. mouse. [Q64704-1 ]

    Organism-specific databases

    CTDi 6809.
    MGIi MGI:103077. Stx3.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110552.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi Q64704.
    KOi K08486.
    PhylomeDBi Q64704.
    TreeFami TF313763.

    Miscellaneous databases

    ChiTaRSi STX3. mouse.
    NextBioi 299785.
    PROi Q64704.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64704.
    Bgeei Q64704.
    CleanExi MM_STX3.
    Genevestigatori Q64704.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3A; 3B; 3C; 3D; 3D-1 AND 3D-2).
      Strain: ICR.
      Tissue: Brain.

    Entry informationi

    Entry nameiSTX3_MOUSE
    AccessioniPrimary (citable) accession number: Q64704
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3