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Protein

Syntaxin-3

Gene

Stx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103077. Stx3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 283Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20
Topological domaini284 – 289ExtracellularSequence analysis6

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • azurophil granule Source: MGI
  • cell-cell junction Source: MGI
  • dendrite Source: MGI
  • extracellular exosome Source: MGI
  • growth cone Source: Ensembl
  • integral component of membrane Source: GO_Central
  • lamellipodium Source: MGI
  • melanosome Source: MGI
  • membrane Source: MGI
  • photoreceptor cell terminal bouton Source: MGI
  • plasma membrane Source: MGI
  • presynaptic membrane Source: MGI
  • ribbon synapse Source: MGI
  • secretory granule Source: MGI
  • SNARE complex Source: MGI
  • specific granule Source: MGI
  • synaptic vesicle Source: MGI
  • zymogen granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102001 – 289Syntaxin-3Add BLAST289

Proteomic databases

PaxDbiQ64704.
PeptideAtlasiQ64704.
PRIDEiQ64704.

PTM databases

iPTMnetiQ64704.
PhosphoSitePlusiQ64704.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041488.
CleanExiMM_STX3.
GenevisibleiQ64704. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203562. 4 interactors.
STRINGi10090.ENSMUSP00000069529.

Structurei

3D structure databases

ProteinModelPortaliQ64704.
SMRiQ64704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ64704.
KOiK08486.
OMAiVITTEYR.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ64704.
TreeFamiTF313763.

Family and domain databases

InterProiIPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF34. PTHR19957:SF34. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3A1 Publication (identifier: Q64704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,243
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFC2049EEE6F
GO
Isoform 3B1 Publication (identifier: Q64704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:287
Mass (Da):32,953
Checksum:iA0417FB810FC7157
GO
Isoform 3C1 Publication (identifier: Q64704-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:269
Mass (Da):30,934
Checksum:i02EA1FCAE471CB33
GO
Isoform 3D1 Publication (identifier: Q64704-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT
     87-289: Missing.

Show »
Length:86
Mass (Da):9,971
Checksum:i948B6A5C88498A9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3D1 Publication (identifier: Q64704-4)
Sequence conflicti75W → R in BAA07454 (PubMed:7598732).1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00634139 – 72IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_00634273 – 86TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_00634487 – 289Missing in isoform 3D. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_006346227 – 289EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3B and isoform 3C. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1.
AK171135 mRNA. Translation: BAE42269.1.
AC126036 Genomic DNA. No translation available.
AC126266 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41444.1.
BC024844 mRNA. Translation: AAH24844.1.
CCDSiCCDS29611.1. [Q64704-2]
CCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRiI60170.
I83197.
I83198.
RefSeqiNP_001020478.1. NM_001025307.1. [Q64704-2]
NP_001273472.1. NM_001286543.1.
NP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneiMm.272264.

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-2]
ENSMUST00000211641; ENSMUSP00000147398; ENSMUSG00000041488. [Q64704-3]
GeneIDi20908.
KEGGimmu:20908.
UCSCiuc008gsy.1. mouse.
uc008gsz.1. mouse. [Q64704-3]
uc008gtb.2. mouse. [Q64704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1.
AK171135 mRNA. Translation: BAE42269.1.
AC126036 Genomic DNA. No translation available.
AC126266 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41444.1.
BC024844 mRNA. Translation: AAH24844.1.
CCDSiCCDS29611.1. [Q64704-2]
CCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRiI60170.
I83197.
I83198.
RefSeqiNP_001020478.1. NM_001025307.1. [Q64704-2]
NP_001273472.1. NM_001286543.1.
NP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneiMm.272264.

3D structure databases

ProteinModelPortaliQ64704.
SMRiQ64704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203562. 4 interactors.
STRINGi10090.ENSMUSP00000069529.

PTM databases

iPTMnetiQ64704.
PhosphoSitePlusiQ64704.

Proteomic databases

PaxDbiQ64704.
PeptideAtlasiQ64704.
PRIDEiQ64704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-2]
ENSMUST00000211641; ENSMUSP00000147398; ENSMUSG00000041488. [Q64704-3]
GeneIDi20908.
KEGGimmu:20908.
UCSCiuc008gsy.1. mouse.
uc008gsz.1. mouse. [Q64704-3]
uc008gtb.2. mouse. [Q64704-1]

Organism-specific databases

CTDi6809.
MGIiMGI:103077. Stx3.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ64704.
KOiK08486.
OMAiVITTEYR.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ64704.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiStx3. mouse.
PROiQ64704.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041488.
CleanExiMM_STX3.
GenevisibleiQ64704. MM.

Family and domain databases

InterProiIPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF34. PTHR19957:SF34. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX3_MOUSE
AccessioniPrimary (citable) accession number: Q64704
Secondary accession number(s): Q3TBP0, Q8R1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.