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Q64704

- STX3_MOUSE

UniProt

Q64704 - STX3_MOUSE

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Protein
Syntaxin-3
Gene
Stx3, Stx3a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  1. arachidonic acid binding Source: Ensembl
  2. protein binding Source: MGI

GO - Biological processi

  1. exocytosis Source: MGI
  2. intracellular protein transport Source: InterPro
  3. long-term synaptic potentiation Source: MGI
  4. membrane fusion Source: Ensembl
  5. neuron projection development Source: Ensembl
  6. neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:103077. Stx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei264 – 28320Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini284 – 2896Extracellular Reviewed prediction

GO - Cellular componenti

  1. SNARE complex Source: Ensembl
  2. apical plasma membrane Source: MGI
  3. azurophil granule Source: Ensembl
  4. cell-cell junction Source: Ensembl
  5. dendrite Source: MGI
  6. growth cone Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. membrane Source: MGI
  9. secretory granule Source: MGI
  10. specific granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Syntaxin-3
PRO_0000210200Add
BLAST

Proteomic databases

MaxQBiQ64704.
PaxDbiQ64704.
PRIDEiQ64704.

PTM databases

PhosphoSiteiQ64704.

Expressioni

Gene expression databases

ArrayExpressiQ64704.
BgeeiQ64704.
CleanExiMM_STX3.
GenevestigatoriQ64704.

Interactioni

Protein-protein interaction databases

BioGridi203562. 4 interactions.
STRINGi10090.ENSMUSP00000108589.

Structurei

3D structure databases

ProteinModelPortaliQ64704.
SMRiQ64704. Positions 31-283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11180 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00730000110552.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ64704.
KOiK08486.
PhylomeDBiQ64704.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 3A (identifier: Q64704-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS    50
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK 100
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ 150
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD 200
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET 250
KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK 289
Length:289
Mass (Da):33,243
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFC2049EEE6F
GO
Isoform 3B (identifier: Q64704-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LAIILASTIG

Show »
Length:283
Mass (Da):32,564
Checksum:iF0FC71579A5BA16D
GO
Isoform 3C (identifier: Q64704-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:269
Mass (Da):30,934
Checksum:i02EA1FCAE471CB33
GO
Isoform 3D (identifier: Q64704-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-289: Missing.

Show »
Length:86
Mass (Da):10,011
Checksum:i146915A25056201B
GO
Isoform 3D-1 (identifier: Q64704-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT

Show »
Length:289
Mass (Da):33,203
Checksum:i75FDF1D1DEB0A330
GO
Isoform 3D-2 (identifier: Q64704-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPRNPLLSPEIELT

Show »
Length:289
Mass (Da):33,173
Checksum:i0288D183DB90F085
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 7234IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C.
VSP_006341Add
BLAST
Alternative sequencei73 – 8614TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D-1.
VSP_006342Add
BLAST
Alternative sequencei73 – 8614TKDDL…TEIKK → LPRNPLLSPEIELT in isoform 3D-2.
VSP_006343Add
BLAST
Alternative sequencei87 – 289203Missing in isoform 3D.
VSP_006344Add
BLAST
Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIG in isoform 3B.
VSP_006345Add
BLAST
Alternative sequencei227 – 28963EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3C.
VSP_006346Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29797 mRNA. Translation: BAA06180.1.
D29798 mRNA. Translation: BAA06181.1. Different termination.
D29799 mRNA. Translation: BAA06182.1.
D29800 mRNA. Translation: BAA06183.1.
D38375 mRNA. Translation: BAA07454.1. Sequence problems.
CCDSiCCDS29612.1. [Q64704-3]
CCDS29613.1. [Q64704-1]
PIRiI60170.
I83197.
I83198.
RefSeqiNP_035632.1. NM_011502.3. [Q64704-3]
NP_689344.1. NM_152220.2. [Q64704-1]
UniGeneiMm.272264.

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488. [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488. [Q64704-3]
GeneIDi20908.
KEGGimmu:20908.
UCSCiuc008gsz.1. mouse. [Q64704-3]
uc008gtb.1. mouse. [Q64704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29797 mRNA. Translation: BAA06180.1 .
D29798 mRNA. Translation: BAA06181.1 . Different termination.
D29799 mRNA. Translation: BAA06182.1 .
D29800 mRNA. Translation: BAA06183.1 .
D38375 mRNA. Translation: BAA07454.1 . Sequence problems.
CCDSi CCDS29612.1. [Q64704-3 ]
CCDS29613.1. [Q64704-1 ]
PIRi I60170.
I83197.
I83198.
RefSeqi NP_035632.1. NM_011502.3. [Q64704-3 ]
NP_689344.1. NM_152220.2. [Q64704-1 ]
UniGenei Mm.272264.

3D structure databases

ProteinModelPortali Q64704.
SMRi Q64704. Positions 31-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203562. 4 interactions.
STRINGi 10090.ENSMUSP00000108589.

PTM databases

PhosphoSitei Q64704.

Proteomic databases

MaxQBi Q64704.
PaxDbi Q64704.
PRIDEi Q64704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069285 ; ENSMUSP00000069529 ; ENSMUSG00000041488 . [Q64704-1 ]
ENSMUST00000075304 ; ENSMUSP00000074776 ; ENSMUSG00000041488 . [Q64704-3 ]
GeneIDi 20908.
KEGGi mmu:20908.
UCSCi uc008gsz.1. mouse. [Q64704-3 ]
uc008gtb.1. mouse. [Q64704-1 ]

Organism-specific databases

CTDi 6809.
MGIi MGI:103077. Stx3.

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00730000110552.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi Q64704.
KOi K08486.
PhylomeDBi Q64704.
TreeFami TF313763.

Miscellaneous databases

ChiTaRSi STX3. mouse.
NextBioi 299785.
PROi Q64704.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64704.
Bgeei Q64704.
CleanExi MM_STX3.
Genevestigatori Q64704.

Family and domain databases

InterProi IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3A; 3B; 3C; 3D; 3D-1 AND 3D-2).
    Strain: ICR.
    Tissue: Brain.

Entry informationi

Entry nameiSTX3_MOUSE
AccessioniPrimary (citable) accession number: Q64704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi