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Protein

Taste receptor type 2 member 38

Gene

TAS2R38

Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 38
Short name:
T2R38
Gene namesi
Name:TAS2R38
OrganismiPapio hamadryas (Hamadryas baboon)
Taxonomic identifieri9557 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 55CytoplasmicSequence analysisAdd BLAST17
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 142CytoplasmicSequence analysisAdd BLAST27
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 190ExtracellularSequence analysisAdd BLAST27
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 251CytoplasmicSequence analysisAdd BLAST40
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 276ExtracellularSequence analysis4
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 333CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822771 – 333Taste receptor type 2 member 38Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ646E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098741.

Family and domain databases

CDDicd15025. 7tm_TAS2R38. 1 hit.
InterProiView protein in InterPro
IPR007960. T2R.
IPR030050. TAS2R38.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF86. PTHR11394:SF86. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q646E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLTHICTV SYEVRSTFLF ISVLEFAVGF LTNAFISLVN FWDVVKRQPL
60 70 80 90 100
SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQVILMLWM
110 120 130 140 150
IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC
160 170 180 190 200
SCICTVLCVW CFFGRLHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL
210 220 230 240 250
WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRDSRDPSLE AHIKALKSLV
260 270 280 290 300
SFFCFFVISS CAAFISVPLL ILWHDKIGVM VCVGIMAACP SGHAAVLISG
310 320 330
NAKLRRAVTT ILLWAQSSLK VRADHMADSR TLC
Length:333
Mass (Da):37,755
Last modified:October 25, 2004 - v1
Checksum:i7FBBD2DCC90825F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724835 Genomic DNA. Translation: AAU21070.1.

Similar proteinsi

Entry informationi

Entry nameiT2R38_PAPHA
AccessioniPrimary (citable) accession number: Q646E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: August 30, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families