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Protein

Taste receptor type 2 member 16

Gene

TAS2R16

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Gene namesi
Name:TAS2R16
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 41CytoplasmicSequence analysisAdd BLAST19
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 125CytoplasmicSequence analysisAdd BLAST20
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 182ExtracellularSequence analysisAdd BLAST36
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 228CytoplasmicSequence analysisAdd BLAST25
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 291CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822641 – 291Taste receptor type 2 member 16Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ646B3.

Interactioni

Subunit structurei

Interacts with RTP3 and RTP4.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033625.

Structurei

3D structure databases

ProteinModelPortaliQ646B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNW. Eukaryota.
ENOG41119UD. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ646B3.
KOiK08474.
OMAiMITCVTI.
OrthoDBiEOG091G0HIR.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q646B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI
60 70 80 90 100
SLGISRFCLQ WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT
110 120 130 140 150
VFYCIKVSSF THHIFLWLRW RILRLFPWIL LGSLMITCVT IIPSAIGNYI
160 170 180 190 200
QIQLLTMEHL PRNSTVTDKL EKFHQYQFQA HTVALVIPFI LFLASTILLM
210 220 230 240 250
ASLTKQIQHH STGHCNPSMK AHFTALRSLA VLFIVFTSYF LTILITIIGT
260 270 280 290
LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C
Length:291
Mass (Da):33,947
Last modified:October 25, 2004 - v1
Checksum:i5498145FC3CF229A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724890 Genomic DNA. Translation: AAU21106.1.
AY724897 Genomic DNA. Translation: AAU21113.1.
RefSeqiNP_001009160.1. NM_001009160.1.
XP_016800871.1. XM_016945382.1.
UniGeneiPtr.6376.

Genome annotation databases

EnsembliENSPTRT00000036368; ENSPTRP00000033625; ENSPTRG00000019634.
GeneIDi107971632.
494113.
KEGGiptr:494113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724890 Genomic DNA. Translation: AAU21106.1.
AY724897 Genomic DNA. Translation: AAU21113.1.
RefSeqiNP_001009160.1. NM_001009160.1.
XP_016800871.1. XM_016945382.1.
UniGeneiPtr.6376.

3D structure databases

ProteinModelPortaliQ646B3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033625.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ646B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000036368; ENSPTRP00000033625; ENSPTRG00000019634.
GeneIDi107971632.
494113.
KEGGiptr:494113.

Organism-specific databases

CTDi50833.

Phylogenomic databases

eggNOGiENOG410IKNW. Eukaryota.
ENOG41119UD. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ646B3.
KOiK08474.
OMAiMITCVTI.
OrthoDBiEOG091G0HIR.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT2R16_PANTR
AccessioniPrimary (citable) accession number: Q646B3
Secondary accession number(s): Q646A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.