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Q646B3

- T2R16_PANTR

UniProt

Q646B3 - T2R16_PANTR

Protein

Taste receptor type 2 member 16

Gene

TAS2R16

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 16
    Short name:
    T2R16
    Gene namesi
    Name:TAS2R16
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Taste receptor type 2 member 16PRO_0000082264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ646B3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 4119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini106 – 12520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 18236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 22825CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 2578ExtracellularSequence Analysis
    Topological domaini279 – 29113CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39234.
    GeneTreeiENSGT00560000076937.
    HOGENOMiHOG000234595.
    HOVERGENiHBG098568.
    InParanoidiQ646B3.
    KOiK08474.
    OMAiMITCVTI.
    OrthoDBiEOG7JDQZC.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q646B3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI    50
    SLGISRFCLQ WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT 100
    VFYCIKVSSF THHIFLWLRW RILRLFPWIL LGSLMITCVT IIPSAIGNYI 150
    QIQLLTMEHL PRNSTVTDKL EKFHQYQFQA HTVALVIPFI LFLASTILLM 200
    ASLTKQIQHH STGHCNPSMK AHFTALRSLA VLFIVFTSYF LTILITIIGT 250
    LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C 291
    Length:291
    Mass (Da):33,947
    Last modified:October 25, 2004 - v1
    Checksum:i5498145FC3CF229A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY724890 Genomic DNA. Translation: AAU21106.1.
    AY724897 Genomic DNA. Translation: AAU21113.1.
    RefSeqiNP_001009160.1. NM_001009160.1.
    UniGeneiPtr.6376.

    Genome annotation databases

    EnsembliENSPTRT00000036368; ENSPTRP00000033625; ENSPTRG00000019634.
    GeneIDi494113.
    KEGGiptr:494113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY724890 Genomic DNA. Translation: AAU21106.1 .
    AY724897 Genomic DNA. Translation: AAU21113.1 .
    RefSeqi NP_001009160.1. NM_001009160.1.
    UniGenei Ptr.6376.

    3D structure databases

    ProteinModelPortali Q646B3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000036368 ; ENSPTRP00000033625 ; ENSPTRG00000019634 .
    GeneIDi 494113.
    KEGGi ptr:494113.

    Organism-specific databases

    CTDi 50833.

    Phylogenomic databases

    eggNOGi NOG39234.
    GeneTreei ENSGT00560000076937.
    HOGENOMi HOG000234595.
    HOVERGENi HBG098568.
    InParanoidi Q646B3.
    KOi K08474.
    OMAi MITCVTI.
    OrthoDBi EOG7JDQZC.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 20865622.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiT2R16_PANTR
    AccessioniPrimary (citable) accession number: Q646B3
    Secondary accession number(s): Q646A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3