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Q646B3

- T2R16_PANTR

UniProt

Q646B3 - T2R16_PANTR

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Protein
Taste receptor type 2 member 16
Gene
TAS2R16
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Gene namesi
Name:TAS2R16
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Extracellular Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini23 – 4119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini63 – 8422Extracellular Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini106 – 12520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini147 – 18236Extracellular Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini204 – 22825Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini250 – 2578Extracellular Reviewed prediction
Transmembranei258 – 27821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini279 – 29113Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Taste receptor type 2 member 16
PRO_0000082264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ646B3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39234.
GeneTreeiENSGT00560000076937.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ646B3.
KOiK08474.
OMAiMITCVTI.
OrthoDBiEOG7JDQZC.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q646B3-1 [UniParc]FASTAAdd to Basket

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MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI    50
SLGISRFCLQ WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT 100
VFYCIKVSSF THHIFLWLRW RILRLFPWIL LGSLMITCVT IIPSAIGNYI 150
QIQLLTMEHL PRNSTVTDKL EKFHQYQFQA HTVALVIPFI LFLASTILLM 200
ASLTKQIQHH STGHCNPSMK AHFTALRSLA VLFIVFTSYF LTILITIIGT 250
LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C 291
Length:291
Mass (Da):33,947
Last modified:October 25, 2004 - v1
Checksum:i5498145FC3CF229A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY724890 Genomic DNA. Translation: AAU21106.1.
AY724897 Genomic DNA. Translation: AAU21113.1.
RefSeqiNP_001009160.1. NM_001009160.1.
UniGeneiPtr.6376.

Genome annotation databases

EnsembliENSPTRT00000036368; ENSPTRP00000033625; ENSPTRG00000019634.
GeneIDi494113.
KEGGiptr:494113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY724890 Genomic DNA. Translation: AAU21106.1 .
AY724897 Genomic DNA. Translation: AAU21113.1 .
RefSeqi NP_001009160.1. NM_001009160.1.
UniGenei Ptr.6376.

3D structure databases

ProteinModelPortali Q646B3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000036368 ; ENSPTRP00000033625 ; ENSPTRG00000019634 .
GeneIDi 494113.
KEGGi ptr:494113.

Organism-specific databases

CTDi 50833.

Phylogenomic databases

eggNOGi NOG39234.
GeneTreei ENSGT00560000076937.
HOGENOMi HOG000234595.
HOVERGENi HBG098568.
InParanoidi Q646B3.
KOi K08474.
OMAi MITCVTI.
OrthoDBi EOG7JDQZC.
TreeFami TF335891.

Miscellaneous databases

NextBioi 20865622.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiT2R16_PANTR
AccessioniPrimary (citable) accession number: Q646B3
Secondary accession number(s): Q646A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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