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Q646B3 (T2R16_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 16

Short name=T2R16
Gene names
Name:TAS2R16
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Taste receptor type 2 member 16
PRO_0000082264

Regions

Topological domain11Extracellular Potential
Transmembrane2 – 2221Helical; Name=1; Potential
Topological domain23 – 4119Cytoplasmic Potential
Transmembrane42 – 6221Helical; Name=2; Potential
Topological domain63 – 8422Extracellular Potential
Transmembrane85 – 10521Helical; Name=3; Potential
Topological domain106 – 12520Cytoplasmic Potential
Transmembrane126 – 14621Helical; Name=4; Potential
Topological domain147 – 18236Extracellular Potential
Transmembrane183 – 20321Helical; Name=5; Potential
Topological domain204 – 22825Cytoplasmic Potential
Transmembrane229 – 24921Helical; Name=6; Potential
Topological domain250 – 2578Extracellular Potential
Transmembrane258 – 27821Helical; Name=7; Potential
Topological domain279 – 29113Cytoplasmic Potential

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q646B3 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 5498145FC3CF229A

FASTA29133,947
        10         20         30         40         50         60 
MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI SLGISRFCLQ 

        70         80         90        100        110        120 
WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT VFYCIKVSSF THHIFLWLRW 

       130        140        150        160        170        180 
RILRLFPWIL LGSLMITCVT IIPSAIGNYI QIQLLTMEHL PRNSTVTDKL EKFHQYQFQA 

       190        200        210        220        230        240 
HTVALVIPFI LFLASTILLM ASLTKQIQHH STGHCNPSMK AHFTALRSLA VLFIVFTSYF 

       250        260        270        280        290 
LTILITIIGT LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C 

« Hide

References

[1]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY724890 Genomic DNA. Translation: AAU21106.1.
AY724897 Genomic DNA. Translation: AAU21113.1.
RefSeqNP_001009160.1. NM_001009160.1.
UniGenePtr.6376.

3D structure databases

ProteinModelPortalQ646B3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000036368; ENSPTRP00000033625; ENSPTRG00000019634.
GeneID494113.
KEGGptr:494113.

Organism-specific databases

CTD50833.

Phylogenomic databases

eggNOGNOG39234.
GeneTreeENSGT00560000076937.
HOGENOMHOG000234595.
HOVERGENHBG098568.
InParanoidQ646B3.
KOK08474.
OMAMITCVTI.
OrthoDBEOG7JDQZC.
TreeFamTF335891.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20865622.

Entry information

Entry nameT2R16_PANTR
AccessionPrimary (citable) accession number: Q646B3
Secondary accession number(s): Q646A6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries