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Protein

Endothelial protein C receptor

Gene

Procr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

  • protein C-terminus binding Source: MGI
  • signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Centrocyclin
Centrosomal protein CCD41
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:Procr
Synonyms:Epcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104596 Procr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 214ExtracellularSequence analysisAdd BLAST197
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 242CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002119218 – 242Endothelial protein C receptorAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 190By similarity
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 236By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ64695
MaxQBiQ64695
PaxDbiQ64695
PeptideAtlasiQ64695
PRIDEiQ64695

PTM databases

iPTMnetiQ64695
PhosphoSitePlusiQ64695
SwissPalmiQ64695

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Gene expression databases

BgeeiENSMUSG00000027611
CleanExiMM_PROCR
ExpressionAtlasiQ64695 baseline and differential
GenevisibleiQ64695 MM

Interactioni

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

IntActiQ64695, 1 interactor
MINTiQ64695
STRINGi10090.ENSMUSP00000029140

Structurei

3D structure databases

ProteinModelPortaliQ64695
SMRiQ64695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ64695
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
TreeFamiTF335868

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKFLPLLL LLLPGCALCN SDGSQSLHML QISYFQDNHH VRHQGNASLG
60 70 80 90 100
KLLTHTLEGP SQNVTILQLQ PWQDPESWER TESGLQIYLT QFESLVKLVY
110 120 130 140 150
RERKENVFFP LTVSCSLGCE LPEEEEEGSE PHVFFDVAVN GSAFVSFRPK
160 170 180 190 200
TAVWVSGSQE PSKAANFTLK QLNAYNRTRY ELQEFLQDTC VEFLENHITT
210 220 230 240
QNMKGSQTGR SYTSLVLGIL MGCFIIAGVA VGIFMCTSGR RC
Length:242
Mass (Da):27,189
Last modified:October 3, 2012 - v3
Checksum:i7215B7F51C81B50A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → L in CAA45281 (PubMed:8449997).Curated1
Sequence conflicti38N → H in CAA45281 (PubMed:8449997).Curated1
Sequence conflicti38N → H in AAC42049 (PubMed:7890676).Curated1
Sequence conflicti38N → H in AAD43351 (PubMed:10235444).Curated1
Sequence conflicti241 – 242RC → GLLII in CAA45281 (PubMed:8449997).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63748 mRNA Translation: CAA45281.2
L39017 mRNA Translation: AAC42049.1
AF162695 Genomic DNA Translation: AAD43351.1
AK143719 mRNA Translation: BAE25514.1
AK167302 mRNA Translation: BAE39407.1
CT010175 mRNA Translation: CAJ18383.1
AL929233 Genomic DNA Translation: CAM22836.1
CH466551 Genomic DNA Translation: EDL06143.1
CCDSiCCDS16954.1
PIRiA55945
S18948
RefSeqiNP_035301.2, NM_011171.2
UniGeneiMm.3243

Genome annotation databases

EnsembliENSMUST00000029140; ENSMUSP00000029140; ENSMUSG00000027611
GeneIDi19124
KEGGimmu:19124
UCSCiuc008nlh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiEPCR_MOUSE
AccessioniPrimary (citable) accession number: Q64695
Secondary accession number(s): Q4FK76, Q9WV33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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