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Protein

Endothelial protein C receptor

Gene

Procr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Centrocyclin
Centrosomal protein CCD41
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:Procr
Synonyms:Epcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104596. Procr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 214197ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 2427CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 242225Endothelial protein C receptorPRO_0000021192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi119 ↔ 190By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi223 ↔ 236By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ64695.
MaxQBiQ64695.
PaxDbiQ64695.
PRIDEiQ64695.

PTM databases

iPTMnetiQ64695.
SwissPalmiQ64695.

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Gene expression databases

CleanExiMM_PROCR.
ExpressionAtlasiQ64695. baseline and differential.
GenevisibleiQ64695. MM.

Interactioni

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

IntActiQ64695. 1 interaction.
MINTiMINT-4094503.
STRINGi10090.ENSMUSP00000029140.

Structurei

3D structure databases

ProteinModelPortaliQ64695.
SMRiQ64695. Positions 25-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ64695.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG7F5131.
TreeFamiTF335868.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKFLPLLL LLLPGCALCN SDGSQSLHML QISYFQDNHH VRHQGNASLG
60 70 80 90 100
KLLTHTLEGP SQNVTILQLQ PWQDPESWER TESGLQIYLT QFESLVKLVY
110 120 130 140 150
RERKENVFFP LTVSCSLGCE LPEEEEEGSE PHVFFDVAVN GSAFVSFRPK
160 170 180 190 200
TAVWVSGSQE PSKAANFTLK QLNAYNRTRY ELQEFLQDTC VEFLENHITT
210 220 230 240
QNMKGSQTGR SYTSLVLGIL MGCFIIAGVA VGIFMCTSGR RC
Length:242
Mass (Da):27,189
Last modified:October 3, 2012 - v3
Checksum:i7215B7F51C81B50A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71P → L in CAA45281 (PubMed:8449997).Curated
Sequence conflicti38 – 381N → H in CAA45281 (PubMed:8449997).Curated
Sequence conflicti38 – 381N → H in AAC42049 (PubMed:7890676).Curated
Sequence conflicti38 – 381N → H in AAD43351 (PubMed:10235444).Curated
Sequence conflicti241 – 2422RC → GLLII in CAA45281 (PubMed:8449997).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63748 mRNA. Translation: CAA45281.2.
L39017 mRNA. Translation: AAC42049.1.
AF162695 Genomic DNA. Translation: AAD43351.1.
AK143719 mRNA. Translation: BAE25514.1.
AK167302 mRNA. Translation: BAE39407.1.
CT010175 mRNA. Translation: CAJ18383.1.
AL929233 Genomic DNA. Translation: CAM22836.1.
CH466551 Genomic DNA. Translation: EDL06143.1.
CCDSiCCDS16954.1.
PIRiA55945.
S18948.
RefSeqiNP_035301.2. NM_011171.2.
UniGeneiMm.3243.

Genome annotation databases

EnsembliENSMUST00000029140; ENSMUSP00000029140; ENSMUSG00000027611.
GeneIDi19124.
KEGGimmu:19124.
UCSCiuc008nlh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63748 mRNA. Translation: CAA45281.2.
L39017 mRNA. Translation: AAC42049.1.
AF162695 Genomic DNA. Translation: AAD43351.1.
AK143719 mRNA. Translation: BAE25514.1.
AK167302 mRNA. Translation: BAE39407.1.
CT010175 mRNA. Translation: CAJ18383.1.
AL929233 Genomic DNA. Translation: CAM22836.1.
CH466551 Genomic DNA. Translation: EDL06143.1.
CCDSiCCDS16954.1.
PIRiA55945.
S18948.
RefSeqiNP_035301.2. NM_011171.2.
UniGeneiMm.3243.

3D structure databases

ProteinModelPortaliQ64695.
SMRiQ64695. Positions 25-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64695. 1 interaction.
MINTiMINT-4094503.
STRINGi10090.ENSMUSP00000029140.

PTM databases

iPTMnetiQ64695.
SwissPalmiQ64695.

Proteomic databases

EPDiQ64695.
MaxQBiQ64695.
PaxDbiQ64695.
PRIDEiQ64695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029140; ENSMUSP00000029140; ENSMUSG00000027611.
GeneIDi19124.
KEGGimmu:19124.
UCSCiuc008nlh.2. mouse.

Organism-specific databases

CTDi10544.
MGIiMGI:104596. Procr.

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ64695.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG7F5131.
TreeFamiTF335868.

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiQ64695.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PROCR.
ExpressionAtlasiQ64695. baseline and differential.
GenevisibleiQ64695. MM.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein."
    Rothbarth K., Petzelt C., Lu X., Todorov I.T., Joswigt G.H., Pepperkok R., Ansorge W., Werner D.
    J. Cell Sci. 104:19-30(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Werner D.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 18-47.
  3. "Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR."
    Fukudome K., Esmon C.T.
    J. Biol. Chem. 270:5571-5577(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hemangioendothelioma.
  4. "Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor."
    Liang Z., Rosen E.D., Castellino F.J.
    Thromb. Haemost. 81:585-588(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta and Spleen.
  6. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiEPCR_MOUSE
AccessioniPrimary (citable) accession number: Q64695
Secondary accession number(s): Q4FK76, Q9WV33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.