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Q64692

- SIA8D_MOUSE

UniProt

Q64692 - SIA8D_MOUSE

Protein

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Gene

St8sia4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

    Pathwayi

    GO - Molecular functioni

    1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: MGI

    GO - Biological processi

    1. ganglioside biosynthetic process Source: Ensembl
    2. N-glycan processing Source: Ensembl
    3. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_202500. Sialic acid metabolism.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC:2.4.99.-)
    Alternative name(s):
    Alpha-2,8-sialyltransferase 8D
    Polysialyltransferase-1
    Sialyltransferase 8D
    Short name:
    SIAT8-D
    Sialyltransferase St8Sia IV
    Short name:
    ST8SiaIV
    Gene namesi
    Name:St8sia4
    Synonyms:Pst, Siat8d
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:106018. St8sia4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferasePRO_0000149294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 292By similarity
    Disulfide bondi156 ↔ 356By similarity
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ64692.
    PRIDEiQ64692.

    PTM databases

    PhosphoSiteiQ64692.

    Expressioni

    Tissue specificityi

    Strongly expressed in lung, heart and spleen and weakly in brain.

    Developmental stagei

    Expressed throughout development at a low level.

    Gene expression databases

    ArrayExpressiQ64692.
    BgeeiQ64692.
    GenevestigatoriQ64692.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64692.
    SMRiQ64692. Positions 131-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini21 – 359339LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2013Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG324948.
    GeneTreeiENSGT00550000074407.
    HOGENOMiHOG000232070.
    HOVERGENiHBG056466.
    InParanoidiQ64692.
    KOiK06614.
    OMAiSVRKRWT.
    OrthoDBiEOG7VQJD1.
    PhylomeDBiQ64692.
    TreeFamiTF352820.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q64692-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELCLSRSLVN    50
    SSDKIIRKAG STIFQHSVQG WKINSSLVLE IRKNILRFLD AERDVSVVKS 100
    SFKPGDVIHY VLDRRRTLNI SHNLHSLLPE VSPMKNRRFK TCAVVGNSGI 150
    LLDSGCGKEI DSHNFVIRCN LAPVVEFAAD VGTKSDFITM NPSVVQRAFG 200
    GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV NALILKNKLQ 250
    VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF 300
    WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK 350
    LTTGKCMKQ 359
    Length:359
    Mass (Da):41,256
    Last modified:November 1, 1996 - v1
    Checksum:i81FE93468579D1EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86000 mRNA. Translation: CAA59992.1.
    CCDSiCCDS15201.1.
    PIRiJC4224.
    RefSeqiNP_001153217.1. NM_001159745.1.
    NP_033209.1. NM_009183.2.
    UniGeneiMm.306228.

    Genome annotation databases

    EnsembliENSMUST00000043336; ENSMUSP00000043477; ENSMUSG00000040710.
    GeneIDi20452.
    KEGGimmu:20452.
    UCSCiuc007cfa.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    ST8Sia IV

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86000 mRNA. Translation: CAA59992.1 .
    CCDSi CCDS15201.1.
    PIRi JC4224.
    RefSeqi NP_001153217.1. NM_001159745.1.
    NP_033209.1. NM_009183.2.
    UniGenei Mm.306228.

    3D structure databases

    ProteinModelPortali Q64692.
    SMRi Q64692. Positions 131-318.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei Q64692.

    Proteomic databases

    PaxDbi Q64692.
    PRIDEi Q64692.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043336 ; ENSMUSP00000043477 ; ENSMUSG00000040710 .
    GeneIDi 20452.
    KEGGi mmu:20452.
    UCSCi uc007cfa.1. mouse.

    Organism-specific databases

    CTDi 7903.
    MGIi MGI:106018. St8sia4.

    Phylogenomic databases

    eggNOGi NOG324948.
    GeneTreei ENSGT00550000074407.
    HOGENOMi HOG000232070.
    HOVERGENi HBG056466.
    InParanoidi Q64692.
    KOi K06614.
    OMAi SVRKRWT.
    OrthoDBi EOG7VQJD1.
    PhylomeDBi Q64692.
    TreeFami TF352820.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_202500. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 298526.
    PROi Q64692.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64692.
    Bgeei Q64692.
    Genevestigatori Q64692.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a third type of N-glycan alpha 2,8-sialyltransferase from mouse lung."
      Yoshida Y., Kojima N., Tsuji S.
      J. Biochem. 118:658-664(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiSIA8D_MOUSE
    AccessioniPrimary (citable) accession number: Q64692
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3