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Q64692

- SIA8D_MOUSE

UniProt

Q64692 - SIA8D_MOUSE

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Protein

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Gene

St8sia4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

Pathwayi

GO - Molecular functioni

  1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: MGI

GO - Biological processi

  1. ganglioside biosynthetic process Source: Ensembl
  2. N-glycan processing Source: Ensembl
  3. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_202500. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC:2.4.99.-)
Alternative name(s):
Alpha-2,8-sialyltransferase 8D
Polysialyltransferase-1
Sialyltransferase 8D
Short name:
SIAT8-D
Sialyltransferase St8Sia IV
Short name:
ST8SiaIV
Gene namesi
Name:St8sia4
Synonyms:Pst, Siat8d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:106018. St8sia4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferasePRO_0000149294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 292By similarity
Disulfide bondi156 ↔ 356By similarity
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64692.
PRIDEiQ64692.

PTM databases

PhosphoSiteiQ64692.

Expressioni

Tissue specificityi

Strongly expressed in lung, heart and spleen and weakly in brain.

Developmental stagei

Expressed throughout development at a low level.

Gene expression databases

BgeeiQ64692.
ExpressionAtlasiQ64692. baseline and differential.
GenevestigatoriQ64692.

Structurei

3D structure databases

ProteinModelPortaliQ64692.
SMRiQ64692. Positions 131-318.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Topological domaini21 – 359339LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2013Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG324948.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
InParanoidiQ64692.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.
PhylomeDBiQ64692.
TreeFamiTF352820.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELCLSRSLVN
60 70 80 90 100
SSDKIIRKAG STIFQHSVQG WKINSSLVLE IRKNILRFLD AERDVSVVKS
110 120 130 140 150
SFKPGDVIHY VLDRRRTLNI SHNLHSLLPE VSPMKNRRFK TCAVVGNSGI
160 170 180 190 200
LLDSGCGKEI DSHNFVIRCN LAPVVEFAAD VGTKSDFITM NPSVVQRAFG
210 220 230 240 250
GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV NALILKNKLQ
260 270 280 290 300
VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF
310 320 330 340 350
WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK

LTTGKCMKQ
Length:359
Mass (Da):41,256
Last modified:November 1, 1996 - v1
Checksum:i81FE93468579D1EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86000 mRNA. Translation: CAA59992.1.
CCDSiCCDS15201.1.
PIRiJC4224.
RefSeqiNP_001153217.1. NM_001159745.1.
NP_033209.1. NM_009183.2.
UniGeneiMm.306228.

Genome annotation databases

EnsembliENSMUST00000043336; ENSMUSP00000043477; ENSMUSG00000040710.
GeneIDi20452.
KEGGimmu:20452.
UCSCiuc007cfa.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST8Sia IV

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86000 mRNA. Translation: CAA59992.1 .
CCDSi CCDS15201.1.
PIRi JC4224.
RefSeqi NP_001153217.1. NM_001159745.1.
NP_033209.1. NM_009183.2.
UniGenei Mm.306228.

3D structure databases

ProteinModelPortali Q64692.
SMRi Q64692. Positions 131-318.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSitei Q64692.

Proteomic databases

PaxDbi Q64692.
PRIDEi Q64692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043336 ; ENSMUSP00000043477 ; ENSMUSG00000040710 .
GeneIDi 20452.
KEGGi mmu:20452.
UCSCi uc007cfa.1. mouse.

Organism-specific databases

CTDi 7903.
MGIi MGI:106018. St8sia4.

Phylogenomic databases

eggNOGi NOG324948.
GeneTreei ENSGT00550000074407.
HOGENOMi HOG000232070.
HOVERGENi HBG056466.
InParanoidi Q64692.
KOi K06614.
OMAi SVRKRWT.
OrthoDBi EOG7VQJD1.
PhylomeDBi Q64692.
TreeFami TF352820.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_202500. Sialic acid metabolism.

Miscellaneous databases

NextBioi 298526.
PROi Q64692.
SOURCEi Search...

Gene expression databases

Bgeei Q64692.
ExpressionAtlasi Q64692. baseline and differential.
Genevestigatori Q64692.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a third type of N-glycan alpha 2,8-sialyltransferase from mouse lung."
    Yoshida Y., Kojima N., Tsuji S.
    J. Biochem. 118:658-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSIA8D_MOUSE
AccessioniPrimary (citable) accession number: Q64692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3