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Protein

Cytochrome P450 2D4

Gene

Cyp2d4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • arachidonic acid monooxygenase activity Source: RGD
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: RGD
  • steroid 21-monooxygenase activity Source: RGD

GO - Biological processi

  • arachidonic acid metabolic process Source: RGD
  • dopamine biosynthetic process Source: RGD
  • dopamine metabolic process Source: RGD
  • drug metabolic process Source: RGD
  • female pregnancy Source: RGD
  • response to organic substance Source: RGD
  • serotonin biosynthetic process from tryptophan Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211981. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D4 (EC:1.14.14.1)
Alternative name(s):
CYPIID18
CYPIID4
Cytochrome P450 2D-29
Cytochrome P450 2D-35
Cytochrome P450 2D18
Cytochrome P450-CMF3
Cytochrome P450-DB4
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d4
Synonyms:Cyp2d-18, Cyp2d-4, Cyp2d18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620640. Cyp2d4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2304403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517421 – 500Cytochrome P450 2D4Add BLAST500

Proteomic databases

PaxDbiQ64680.
PRIDEiQ64680.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000032261.
GenevisibleiQ64680. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011880.

Chemistry databases

BindingDBiQ64680.

Structurei

3D structure databases

ProteinModelPortaliQ64680.
SMRiQ64680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
HOVERGENiHBG015789.
InParanoidiQ64680.
KOiK07414.
OMAiAFNADDY.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ64680.
TreeFamiTF352043.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMPTGSELW PIAIFTIIFL LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QIDFQNMPAG FQKLRCRFGD LFSLQLAFES VVVLNGLPAL REALVKYSED
110 120 130 140 150
TADRPPLHFN DQSGFGPRSQ GVVLARYGPA WRQQRRFSVS TFRHFGLGKK
160 170 180 190 200
SLEQWVTEEA RCLCAAFADH SGFPFSPNTL LDKAVCNVIA SLLFACRFEY
210 220 230 240 250
NDPRFIRLLD LLKDTLEEES GFLPMLLNVF PMLLHIPGLL GKVFSGKKAF
260 270 280 290 300
VAMLDELLTE HKVTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRV
310 320 330 340 350
VVADLFMAGM VTTSTTLTWA LLFMILRPDV QCRVQQEIDE VIGQVRRPEM
360 370 380 390 400
ADQARMPFTN AVIHEVQRFA DILPLGVPHK TSRDIEVQGF LIPKGTTLII
410 420 430 440 450
NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPAGQPRPSN YGVFGALTTP RPYQLCASPR
Length:500
Mass (Da):56,684
Last modified:November 1, 1996 - v1
Checksum:i9848A8BE5ABA09C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327R → H in CAA36271 (PubMed:2107330).Curated1
Sequence conflicti327R → H in BAA23125 (PubMed:9434752).Curated1
Sequence conflicti327R → H in AAA41052 (PubMed:3190674).Curated1
Sequence conflicti400I → T in CAA36271 (PubMed:2107330).Curated1
Sequence conflicti400I → T in BAA23125 (PubMed:9434752).Curated1
Sequence conflicti400I → T in AAA41052 (PubMed:3190674).Curated1
Sequence conflicti473A → T in CAA36271 (PubMed:2107330).Curated1
Sequence conflicti473A → T in AAA41052 (PubMed:3190674).Curated1
Sequence conflicti480N → D in CAA36271 (PubMed:2107330).Curated1
Sequence conflicti480N → D in AAA41052 (PubMed:3190674).Curated1
Sequence conflicti483V → I in CAA36271 (PubMed:2107330).Curated1
Sequence conflicti483V → I in AAA41052 (PubMed:3190674).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52029 Genomic DNA. Translation: CAA36271.1.
U48220 mRNA. Translation: AAC52883.1.
U48219 mRNA. Translation: AAC52882.1.
AB008425 mRNA. Translation: BAA23125.1.
BC093609 mRNA. Translation: AAH93609.1.
M22331 mRNA. Translation: AAA41052.1.
RefSeqiNP_612524.1. NM_138515.2.
UniGeneiRn.26060.

Genome annotation databases

EnsembliENSRNOT00000011880; ENSRNOP00000011880; ENSRNOG00000032261.
GeneIDi171522.
KEGGirno:171522.
UCSCiRGD:620640. rat.

Similar proteinsi

Entry informationi

Entry nameiCP2D4_RAT
AccessioniPrimary (citable) accession number: Q64680
Secondary accession number(s): O35107, P13108, Q566D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families