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Q64680

- CP2DI_RAT

UniProt

Q64680 - CP2DI_RAT

Protein

Cytochrome P450 2D18

Gene

Cyp2d18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. arachidonic acid monooxygenase activity Source: RGD
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. monooxygenase activity Source: RGD
    6. steroid 21-monooxygenase activity Source: RGD

    GO - Biological processi

    1. arachidonic acid metabolic process Source: RGD
    2. dopamine biosynthetic process Source: RGD
    3. dopamine metabolic process Source: RGD
    4. drug metabolic process Source: RGD
    5. female pregnancy Source: RGD
    6. response to organic substance Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D18 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID18
    Cytochrome P450 2D-29
    Cytochrome P450 2D-35
    Gene namesi
    Name:Cyp2d18
    Synonyms:Cyp2d-18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620640. Cyp2d18.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D18PRO_0000051742Add
    BLAST

    Proteomic databases

    PRIDEiQ64680.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    GenevestigatoriQ64680.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ64680.
    SMRiQ64680. Positions 37-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00750000117392.
    HOVERGENiHBG015789.
    InParanoidiQ64680.
    KOiK07414.
    OMAiVTEEARC.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ64680.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMPTGSELW PIAIFTIIFL LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL    50
    QIDFQNMPAG FQKLRCRFGD LFSLQLAFES VVVLNGLPAL REALVKYSED 100
    TADRPPLHFN DQSGFGPRSQ GVVLARYGPA WRQQRRFSVS TFRHFGLGKK 150
    SLEQWVTEEA RCLCAAFADH SGFPFSPNTL LDKAVCNVIA SLLFACRFEY 200
    NDPRFIRLLD LLKDTLEEES GFLPMLLNVF PMLLHIPGLL GKVFSGKKAF 250
    VAMLDELLTE HKVTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRV 300
    VVADLFMAGM VTTSTTLTWA LLFMILRPDV QCRVQQEIDE VIGQVRRPEM 350
    ADQARMPFTN AVIHEVQRFA DILPLGVPHK TSRDIEVQGF LIPKGTTLII 400
    NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP 450
    LARMELFLFF TCLLQRFSFS VPAGQPRPSN YGVFGALTTP RPYQLCASPR 500
    Length:500
    Mass (Da):56,684
    Last modified:November 1, 1996 - v1
    Checksum:i9848A8BE5ABA09C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48220 mRNA. Translation: AAC52883.1.
    U48219 mRNA. Translation: AAC52882.1.
    BC093609 mRNA. Translation: AAH93609.1.
    RefSeqiNP_612524.1. NM_138515.2.
    UniGeneiRn.26060.

    Genome annotation databases

    EnsembliENSRNOT00000011880; ENSRNOP00000011880; ENSRNOG00000032261.
    GeneIDi171522.
    KEGGirno:171522.
    UCSCiRGD:620640. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48220 mRNA. Translation: AAC52883.1 .
    U48219 mRNA. Translation: AAC52882.1 .
    BC093609 mRNA. Translation: AAH93609.1 .
    RefSeqi NP_612524.1. NM_138515.2.
    UniGenei Rn.26060.

    3D structure databases

    ProteinModelPortali Q64680.
    SMRi Q64680. Positions 37-500.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q64680.

    Proteomic databases

    PRIDEi Q64680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011880 ; ENSRNOP00000011880 ; ENSRNOG00000032261 .
    GeneIDi 171522.
    KEGGi rno:171522.
    UCSCi RGD:620640. rat.

    Organism-specific databases

    CTDi 171522.
    RGDi 620640. Cyp2d18.

    Phylogenomic databases

    GeneTreei ENSGT00750000117392.
    HOVERGENi HBG015789.
    InParanoidi Q64680.
    KOi K07414.
    OMAi VTEEARC.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q64680.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 622501.
    PROi Q64680.

    Gene expression databases

    Genevestigatori Q64680.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily."
      Kawashima H., Strobel H.W.
      Biochem. Biophys. Res. Commun. 209:535-540(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP2DI_RAT
    AccessioniPrimary (citable) accession number: Q64680
    Secondary accession number(s): Q566D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3