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Q64680 (CP2DI_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D18

EC=1.14.14.1
Alternative name(s):
CYPIID18
Cytochrome P450 2D-29
Cytochrome P450 2D-35
Gene names
Name:Cyp2d18
Synonyms:Cyp2d-18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Brain.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2D18
PRO_0000051742

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64680 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9848A8BE5ABA09C5

FASTA50056,684
        10         20         30         40         50         60 
MRMPTGSELW PIAIFTIIFL LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL QIDFQNMPAG 

        70         80         90        100        110        120 
FQKLRCRFGD LFSLQLAFES VVVLNGLPAL REALVKYSED TADRPPLHFN DQSGFGPRSQ 

       130        140        150        160        170        180 
GVVLARYGPA WRQQRRFSVS TFRHFGLGKK SLEQWVTEEA RCLCAAFADH SGFPFSPNTL 

       190        200        210        220        230        240 
LDKAVCNVIA SLLFACRFEY NDPRFIRLLD LLKDTLEEES GFLPMLLNVF PMLLHIPGLL 

       250        260        270        280        290        300 
GKVFSGKKAF VAMLDELLTE HKVTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRV 

       310        320        330        340        350        360 
VVADLFMAGM VTTSTTLTWA LLFMILRPDV QCRVQQEIDE VIGQVRRPEM ADQARMPFTN 

       370        380        390        400        410        420 
AVIHEVQRFA DILPLGVPHK TSRDIEVQGF LIPKGTTLII NLSSVLKDET VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPAGQPRPSN 

       490        500 
YGVFGALTTP RPYQLCASPR 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily."
Kawashima H., Strobel H.W.
Biochem. Biophys. Res. Commun. 209:535-540(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48220 mRNA. Translation: AAC52883.1.
U48219 mRNA. Translation: AAC52882.1.
BC093609 mRNA. Translation: AAH93609.1.
RefSeqNP_612524.1. NM_138515.2.
UniGeneRn.26060.

3D structure databases

ProteinModelPortalQ64680.
SMRQ64680. Positions 37-500.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ64680.

Proteomic databases

PRIDEQ64680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011880; ENSRNOP00000011880; ENSRNOG00000032261.
GeneID171522.
KEGGrno:171522.
UCSCRGD:620640. rat.

Organism-specific databases

CTD171522.
RGD620640. Cyp2d18.

Phylogenomic databases

GeneTreeENSGT00750000117392.
HOVERGENHBG015789.
InParanoidQ64680.
KOK07414.
OMAVTEEARC.
OrthoDBEOG7RBZ85.
PhylomeDBQ64680.
TreeFamTF352043.

Gene expression databases

GenevestigatorQ64680.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622501.
PROQ64680.

Entry information

Entry nameCP2DI_RAT
AccessionPrimary (citable) accession number: Q64680
Secondary accession number(s): Q566D3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families