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Q64680

- CP2DI_RAT

UniProt

Q64680 - CP2DI_RAT

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Protein

Cytochrome P450 2D18

Gene

Cyp2d18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid monooxygenase activity Source: RGD
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. monooxygenase activity Source: RGD
  6. steroid 21-monooxygenase activity Source: RGD

GO - Biological processi

  1. arachidonic acid metabolic process Source: RGD
  2. dopamine biosynthetic process Source: RGD
  3. dopamine metabolic process Source: RGD
  4. drug metabolic process Source: RGD
  5. female pregnancy Source: RGD
  6. response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D18 (EC:1.14.14.1)
Alternative name(s):
CYPIID18
Cytochrome P450 2D-29
Cytochrome P450 2D-35
Gene namesi
Name:Cyp2d18
Synonyms:Cyp2d-18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620640. Cyp2d18.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: RGD
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2D18PRO_0000051742Add
BLAST

Proteomic databases

PRIDEiQ64680.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

GenevestigatoriQ64680.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ64680.
SMRiQ64680. Positions 37-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiQ64680.
KOiK07414.
OMAiVTEEARC.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ64680.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRMPTGSELW PIAIFTIIFL LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QIDFQNMPAG FQKLRCRFGD LFSLQLAFES VVVLNGLPAL REALVKYSED
110 120 130 140 150
TADRPPLHFN DQSGFGPRSQ GVVLARYGPA WRQQRRFSVS TFRHFGLGKK
160 170 180 190 200
SLEQWVTEEA RCLCAAFADH SGFPFSPNTL LDKAVCNVIA SLLFACRFEY
210 220 230 240 250
NDPRFIRLLD LLKDTLEEES GFLPMLLNVF PMLLHIPGLL GKVFSGKKAF
260 270 280 290 300
VAMLDELLTE HKVTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRV
310 320 330 340 350
VVADLFMAGM VTTSTTLTWA LLFMILRPDV QCRVQQEIDE VIGQVRRPEM
360 370 380 390 400
ADQARMPFTN AVIHEVQRFA DILPLGVPHK TSRDIEVQGF LIPKGTTLII
410 420 430 440 450
NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPAGQPRPSN YGVFGALTTP RPYQLCASPR
Length:500
Mass (Da):56,684
Last modified:November 1, 1996 - v1
Checksum:i9848A8BE5ABA09C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48220 mRNA. Translation: AAC52883.1.
U48219 mRNA. Translation: AAC52882.1.
BC093609 mRNA. Translation: AAH93609.1.
RefSeqiNP_612524.1. NM_138515.2.
UniGeneiRn.26060.

Genome annotation databases

EnsembliENSRNOT00000011880; ENSRNOP00000011880; ENSRNOG00000032261.
GeneIDi171522.
KEGGirno:171522.
UCSCiRGD:620640. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48220 mRNA. Translation: AAC52883.1 .
U48219 mRNA. Translation: AAC52882.1 .
BC093609 mRNA. Translation: AAH93609.1 .
RefSeqi NP_612524.1. NM_138515.2.
UniGenei Rn.26060.

3D structure databases

ProteinModelPortali Q64680.
SMRi Q64680. Positions 37-500.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q64680.

Proteomic databases

PRIDEi Q64680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011880 ; ENSRNOP00000011880 ; ENSRNOG00000032261 .
GeneIDi 171522.
KEGGi rno:171522.
UCSCi RGD:620640. rat.

Organism-specific databases

CTDi 171522.
RGDi 620640. Cyp2d18.

Phylogenomic databases

GeneTreei ENSGT00760000118775.
HOVERGENi HBG015789.
InParanoidi Q64680.
KOi K07414.
OMAi VTEEARC.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q64680.
TreeFami TF352043.

Miscellaneous databases

NextBioi 622501.
PROi Q64680.

Gene expression databases

Genevestigatori Q64680.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily."
    Kawashima H., Strobel H.W.
    Biochem. Biophys. Res. Commun. 209:535-540(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP2DI_RAT
AccessioniPrimary (citable) accession number: Q64680
Secondary accession number(s): Q566D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3