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Q64663

- P2RX7_RAT

UniProt

Q64663 - P2RX7_RAT

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Protein

P2X purinoceptor 7

Gene
P2rx7
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. channel activity Source: MGI
  3. copper ion binding Source: RGD
  4. extracellular ATP-gated cation channel activity Source: BHF-UCL
  5. lipopolysaccharide binding Source: Ensembl
  6. magnesium ion binding Source: RGD
  7. protein binding Source: UniProtKB
  8. protein serine/threonine kinase activator activity Source: RGD
  9. purinergic nucleotide receptor activity Source: BHF-UCL
  10. receptor binding Source: BHF-UCL
  11. scaffold protein binding Source: RGD
  12. zinc ion binding Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. apoptotic signaling pathway Source: BHF-UCL
  3. bleb assembly Source: BHF-UCL
  4. cell morphogenesis Source: Ensembl
  5. cell surface receptor signaling pathway Source: BHF-UCL
  6. cellular response to extracellular stimulus Source: Ensembl
  7. cell volume homeostasis Source: Ensembl
  8. ceramide biosynthetic process Source: Ensembl
  9. collagen metabolic process Source: Ensembl
  10. cytolysis Source: Ensembl
  11. defense response to Gram-positive bacterium Source: Ensembl
  12. homeostasis of number of cells within a tissue Source: Ensembl
  13. inflammatory response Source: Ensembl
  14. membrane budding Source: Ensembl
  15. membrane depolarization Source: BHF-UCL
  16. membrane protein ectodomain proteolysis Source: Ensembl
  17. mitochondrion organization Source: Ensembl
  18. multicellular organismal protein catabolic process Source: Ensembl
  19. NAD transport Source: Ensembl
  20. negative regulation of bone resorption Source: Ensembl
  21. negative regulation of MAPK cascade Source: Ensembl
  22. neuronal action potential Source: RGD
  23. organic cation transport Source: RGD
  24. phagolysosome assembly Source: Ensembl
  25. phospholipid transfer to membrane Source: Ensembl
  26. phospholipid translocation Source: Ensembl
  27. plasma membrane organization Source: Ensembl
  28. pore complex assembly Source: RGD
  29. positive regulation of bone mineralization Source: Ensembl
  30. positive regulation of cytolysis Source: BHF-UCL
  31. positive regulation of cytoskeleton organization Source: BHF-UCL
  32. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
  33. positive regulation of glutamate secretion Source: Ensembl
  34. positive regulation of interleukin-1 alpha secretion Source: Ensembl
  35. positive regulation of interleukin-1 beta secretion Source: RGD
  36. positive regulation of interleukin-6 production Source: Ensembl
  37. positive regulation of lymphocyte apoptotic process Source: Ensembl
  38. positive regulation of mitochondrial depolarization Source: Ensembl
  39. positive regulation of prostaglandin secretion Source: Ensembl
  40. positive regulation of protein phosphorylation Source: RGD
  41. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  42. protein oligomerization Source: Ensembl
  43. protein phosphorylation Source: Ensembl
  44. protein processing Source: Ensembl
  45. purinergic nucleotide receptor signaling pathway Source: GOC
  46. reactive oxygen species metabolic process Source: Ensembl
  47. regulation of sodium ion transport Source: BHF-UCL
  48. release of sequestered calcium ion into cytosol Source: Ensembl
  49. response to ATP Source: BHF-UCL
  50. response to calcium ion Source: Ensembl
  51. response to drug Source: Ensembl
  52. response to electrical stimulus Source: Ensembl
  53. response to fluid shear stress Source: Ensembl
  54. response to lipopolysaccharide Source: Ensembl
  55. response to mechanical stimulus Source: Ensembl
  56. response to zinc ion Source: Ensembl
  57. sensory perception of pain Source: Ensembl
  58. skeletal system morphogenesis Source: Ensembl
  59. synaptic vesicle exocytosis Source: Ensembl
  60. T cell homeostasis Source: Ensembl
  61. T cell proliferation Source: Ensembl
  62. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196450. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 7
Short name:
P2X7
Alternative name(s):
ATP receptor
P2Z receptor
Purinergic receptor
Gene namesi
Name:P2rx7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi3241. P2rx7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 334288Extracellular Reviewed predictionAdd
BLAST
Transmembranei335 – 35521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini356 – 595240Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. bleb Source: BHF-UCL
  2. cell-cell junction Source: Ensembl
  3. cytoplasm Source: BHF-UCL
  4. external side of plasma membrane Source: Ensembl
  5. integral component of nuclear inner membrane Source: RGD
  6. integral component of plasma membrane Source: Ensembl
  7. membrane raft Source: RGD
  8. neuromuscular junction Source: Ensembl
  9. neuronal cell body Source: Ensembl
  10. neuron projection Source: RGD
  11. plasma membrane Source: BHF-UCL
  12. protein complex Source: RGD
  13. terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595P2X purinoceptor 7PRO_0000161562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi119 ↔ 168 By similarity
Modified residuei125 – 1251ADP-ribosylarginine By similarity
Disulfide bondi129 ↔ 152 By similarity
Disulfide bondi135 ↔ 162 By similarity
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi216 ↔ 226 By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi260 ↔ 269 By similarity
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylation results in its inactivation By similarity.
ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel By similarity.
Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface By similarity.

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ64663.
PRIDEiQ64663.

PTM databases

PhosphoSiteiQ64663.

Expressioni

Gene expression databases

GenevestigatoriQ64663.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB By similarity.

Protein-protein interaction databases

BioGridi248286. 11 interactions.
IntActiQ64663. 2 interactions.
MINTiMINT-3379474.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38999.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ64663.
KOiK05220.
OMAiLCPEYPT.
OrthoDBiEOG78PV92.
PhylomeDBiQ64663.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64663-1 [UniParc]FASTAAdd to Basket

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MPACCSWNDV FQYETNKVTR IQSVNYGTIK WILHMTVFSY VSFALMSDKL    50
YQRKEPLISS VHTKVKGVAE VTENVTEGGV TKLVHGIFDT ADYTLPLQGN 100
SFFVMTNYLK SEGQEQKLCP EYPSRGKQCH SDQGCIKGWM DPQSKGIQTG 150
RCIPYDQKRK TCEIFAWCPA EEGKEAPRPA LLRSAENFTV LIKNNIDFPG 200
HNYTTRNILP GMNISCTFHK TWNPQCPIFR LGDIFQEIGE NFTEVAVQGG 250
IMGIEIYWDC NLDSWSHRCQ PKYSFRRLDD KYTNESLFPG YNFRYAKYYK 300
ENGMEKRTLI KAFGVRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC 350
IDLIINTYAS TCCRSRVYPS CKCCEPCAVN EYYYRKKCEP IVEPKPTLKY 400
VSFVDEPHIW MVDQQLLGKS LQDVKGQEVP RPQTDFLELS RLSLSLHHSP 450
PIPGQPEEMQ LLQIEAVPRS RDSPDWCQCG NCLPSQLPEN RRALEELCCR 500
RKPGQCITTS ELFSKIVLSR EALQLLLLYQ EPLLALEGEA INSKLRHCAY 550
RSYATWRFVS QDMADFAILP SCCRWKIRKE FPKTQGQYSG FKYPY 595
Length:595
Mass (Da):68,392
Last modified:November 1, 1996 - v1
Checksum:i4A6DD6058E5988D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95882 mRNA. Translation: CAA65131.1.
RefSeqiNP_062129.1. NM_019256.1.
UniGeneiRn.10510.

Genome annotation databases

EnsembliENSRNOT00000001746; ENSRNOP00000001746; ENSRNOG00000001296.
GeneIDi29665.
KEGGirno:29665.
UCSCiRGD:3241. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95882 mRNA. Translation: CAA65131.1 .
RefSeqi NP_062129.1. NM_019256.1.
UniGenei Rn.10510.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248286. 11 interactions.
IntActi Q64663. 2 interactions.
MINTi MINT-3379474.

Chemistry

BindingDBi Q64663.
ChEMBLi CHEMBL2496.
GuidetoPHARMACOLOGYi 484.

PTM databases

PhosphoSitei Q64663.

Proteomic databases

PaxDbi Q64663.
PRIDEi Q64663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001746 ; ENSRNOP00000001746 ; ENSRNOG00000001296 .
GeneIDi 29665.
KEGGi rno:29665.
UCSCi RGD:3241. rat.

Organism-specific databases

CTDi 5027.
RGDi 3241. P2rx7.

Phylogenomic databases

eggNOGi NOG38999.
GeneTreei ENSGT00390000016028.
HOGENOMi HOG000232042.
HOVERGENi HBG053086.
InParanoidi Q64663.
KOi K05220.
OMAi LCPEYPT.
OrthoDBi EOG78PV92.
PhylomeDBi Q64663.
TreeFami TF328633.

Enzyme and pathway databases

Reactomei REACT_196450. The NLRP3 inflammasome.

Miscellaneous databases

NextBioi 609971.
PROi Q64663.

Gene expression databases

Genevestigatori Q64663.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsi TIGR00863. P2X. 1 hit.
PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)."
    Surprenant A., Rassendren F., Kawashima E., North R.A., Buell G.N.
    Science 272:735-738(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: M33.

Entry informationi

Entry nameiP2RX7_RAT
AccessioniPrimary (citable) accession number: Q64663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi