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Q64658

- C11B2_MESAU

UniProt

Q64658 - C11B2_MESAU

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Protein

Cytochrome P450 11B2, mitochondrial

Gene

CYP11B2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Converts 11-deoxycorticosterone into corticosterone, 18-hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone By similarity.By similarity

Catalytic activityi

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.
Corticosterone + reduced adrenodoxin + O2 = 18-hydroxycorticosterone + oxidized adrenodoxin + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. corticosterone 18-monooxygenase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 11-beta-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. aldosterone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B2, mitochondrial
Alternative name(s):
Aldosterone synthase (EC:1.14.15.4, EC:1.14.15.5)
Short name:
ALDOS
Aldosterone-synthesizing enzyme
CYPXIB2
Cytochrome P-450Aldo
Cytochrome P-450C18
Steroid 18-hydroxylase
Gene namesi
Name:CYP11B2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionBy similarityAdd
BLAST
Chaini25 – 500476Cytochrome P450 11B2, mitochondrialPRO_0000003599Add
BLAST

Expressioni

Tissue specificityi

Adrenal gland.

Inductioni

By low sodium intake.

Structurei

3D structure databases

ProteinModelPortaliQ64658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64658-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL
60 70 80 90 100
KMLQILREEG QEGLHLEMHE AFRELGPIFR YSMGRTQVVS VMLPEDAEKL
110 120 130 140 150
HQVESMHPRR MHLEPWVAHR EHRGLSRGVF LLNGPEWRFN RLRLNPHVLS
160 170 180 190 200
PKAVQKFVPM VDMVARDFLE SLKKKVFQNA RGSLTMDVQQ SLFNYSIEAS
210 220 230 240 250
NFVLFGERLG LLGHDLSPAS LTFIHALHSV FKTTPQLMFL PRSLTRWTST
260 270 280 290 300
RVWKEHFEAW DVISEYVNRC IRKVHQELRL GSPHTYSGIV AELMSQGALP
310 320 330 340 350
LDAIRANSIE LTAGSVDTTT FPLVMALFEL ARNPDVQQAV RQESLAAEAS
360 370 380 390 400
VAANPQRAMS DLPLLRAVLK ETLRLYPVGG FLERILSSDL VLQNYHVPAG
410 420 430 440 450
TLVLLYLYSM GRNPAVFPRP EHYLPQRWLE RNGSFQHLTF GFGVRQCLGK
460 470 480 490 500
RLAQVEMLLL LHHVLKSFRV ETQEREDVRM VYRFVLAPSS SPLLTFRPVS
Length:500
Mass (Da):57,332
Last modified:November 1, 1996 - v1
Checksum:i38251EDAD2085DE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73810 mRNA. Translation: AAB31349.1.
U71280 Genomic DNA. Translation: AAB16805.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73810 mRNA. Translation: AAB31349.1 .
U71280 Genomic DNA. Translation: AAB16805.1 .

3D structure databases

ProteinModelPortali Q64658.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00408. MITP450.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The presence of two cytochrome P450 aldosterone synthase mRNAs in the hamster adrenal."
    Lehoux J.-G., Mason J.I., Bernard H., Ducharme L., Lehoux J., Veronneau S., Lefebvre A.
    J. Steroid Biochem. Mol. Biol. 49:131-137(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal glomerulosa.
  2. "Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase."
    Coulombe N., Lefebvre A., Lehoux J.-G.
    DNA Cell Biol. 16:993-1002(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiC11B2_MESAU
AccessioniPrimary (citable) accession number: Q64658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3