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Q64658

- C11B2_MESAU

UniProt

Q64658 - C11B2_MESAU

Protein

Cytochrome P450 11B2, mitochondrial

Gene

CYP11B2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Converts 11-deoxycorticosterone into corticosterone, 18-hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone By similarity.By similarity

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.
    Corticosterone + reduced adrenodoxin + O2 = 18-hydroxycorticosterone + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. corticosterone 18-monooxygenase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 11-beta-monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. aldosterone biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B2, mitochondrial
    Alternative name(s):
    Aldosterone synthase (EC:1.14.15.4, EC:1.14.15.5)
    Short name:
    ALDOS
    Aldosterone-synthesizing enzyme
    CYPXIB2
    Cytochrome P-450Aldo
    Cytochrome P-450C18
    Steroid 18-hydroxylase
    Gene namesi
    Name:CYP11B2
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionBy similarityAdd
    BLAST
    Chaini25 – 500476Cytochrome P450 11B2, mitochondrialPRO_0000003599Add
    BLAST

    Expressioni

    Tissue specificityi

    Adrenal gland.

    Inductioni

    By low sodium intake.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64658.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00408. MITP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64658-1 [UniParc]FASTAAdd to Basket

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    MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL    50
    KMLQILREEG QEGLHLEMHE AFRELGPIFR YSMGRTQVVS VMLPEDAEKL 100
    HQVESMHPRR MHLEPWVAHR EHRGLSRGVF LLNGPEWRFN RLRLNPHVLS 150
    PKAVQKFVPM VDMVARDFLE SLKKKVFQNA RGSLTMDVQQ SLFNYSIEAS 200
    NFVLFGERLG LLGHDLSPAS LTFIHALHSV FKTTPQLMFL PRSLTRWTST 250
    RVWKEHFEAW DVISEYVNRC IRKVHQELRL GSPHTYSGIV AELMSQGALP 300
    LDAIRANSIE LTAGSVDTTT FPLVMALFEL ARNPDVQQAV RQESLAAEAS 350
    VAANPQRAMS DLPLLRAVLK ETLRLYPVGG FLERILSSDL VLQNYHVPAG 400
    TLVLLYLYSM GRNPAVFPRP EHYLPQRWLE RNGSFQHLTF GFGVRQCLGK 450
    RLAQVEMLLL LHHVLKSFRV ETQEREDVRM VYRFVLAPSS SPLLTFRPVS 500
    Length:500
    Mass (Da):57,332
    Last modified:November 1, 1996 - v1
    Checksum:i38251EDAD2085DE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73810 mRNA. Translation: AAB31349.1.
    U71280 Genomic DNA. Translation: AAB16805.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73810 mRNA. Translation: AAB31349.1 .
    U71280 Genomic DNA. Translation: AAB16805.1 .

    3D structure databases

    ProteinModelPortali Q64658.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051098.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00408. MITP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The presence of two cytochrome P450 aldosterone synthase mRNAs in the hamster adrenal."
      Lehoux J.-G., Mason J.I., Bernard H., Ducharme L., Lehoux J., Veronneau S., Lefebvre A.
      J. Steroid Biochem. Mol. Biol. 49:131-137(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal glomerulosa.
    2. "Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase."
      Coulombe N., Lefebvre A., Lehoux J.-G.
      DNA Cell Biol. 16:993-1002(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiC11B2_MESAU
    AccessioniPrimary (citable) accession number: Q64658
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3