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Q64658 (C11B2_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 11B2, mitochondrial
Alternative name(s):
Aldosterone synthase
Short name=ALDOS
EC=1.14.15.4
EC=1.14.15.5
Aldosterone-synthesizing enzyme
CYPXIB2
Cytochrome P-450Aldo
Cytochrome P-450C18
Steroid 18-hydroxylase
Gene names
Name:CYP11B2
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts 11-deoxycorticosterone into corticosterone, 18-hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone By similarity.

Catalytic activity

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

Corticosterone + reduced adrenodoxin + O2 = 18-hydroxycorticosterone + oxidized adrenodoxin + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Mitochondrion membrane.

Tissue specificity

Adrenal gland.

Induction

By low sodium intake.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion By similarity
Chain25 – 500476Cytochrome P450 11B2, mitochondrial
PRO_0000003599

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64658 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 38251EDAD2085DE8

FASTA50057,332
        10         20         30         40         50         60 
MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL KMLQILREEG 

        70         80         90        100        110        120 
QEGLHLEMHE AFRELGPIFR YSMGRTQVVS VMLPEDAEKL HQVESMHPRR MHLEPWVAHR 

       130        140        150        160        170        180 
EHRGLSRGVF LLNGPEWRFN RLRLNPHVLS PKAVQKFVPM VDMVARDFLE SLKKKVFQNA 

       190        200        210        220        230        240 
RGSLTMDVQQ SLFNYSIEAS NFVLFGERLG LLGHDLSPAS LTFIHALHSV FKTTPQLMFL 

       250        260        270        280        290        300 
PRSLTRWTST RVWKEHFEAW DVISEYVNRC IRKVHQELRL GSPHTYSGIV AELMSQGALP 

       310        320        330        340        350        360 
LDAIRANSIE LTAGSVDTTT FPLVMALFEL ARNPDVQQAV RQESLAAEAS VAANPQRAMS 

       370        380        390        400        410        420 
DLPLLRAVLK ETLRLYPVGG FLERILSSDL VLQNYHVPAG TLVLLYLYSM GRNPAVFPRP 

       430        440        450        460        470        480 
EHYLPQRWLE RNGSFQHLTF GFGVRQCLGK RLAQVEMLLL LHHVLKSFRV ETQEREDVRM 

       490        500 
VYRFVLAPSS SPLLTFRPVS 

« Hide

References

[1]"The presence of two cytochrome P450 aldosterone synthase mRNAs in the hamster adrenal."
Lehoux J.-G., Mason J.I., Bernard H., Ducharme L., Lehoux J., Veronneau S., Lefebvre A.
J. Steroid Biochem. Mol. Biol. 49:131-137(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal glomerulosa.
[2]"Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase."
Coulombe N., Lefebvre A., Lehoux J.-G.
DNA Cell Biol. 16:993-1002(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S73810 mRNA. Translation: AAB31349.1.
U71280 Genomic DNA. Translation: AAB16805.1.

3D structure databases

ProteinModelPortalQ64658.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051098.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00408. MITP450.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC11B2_MESAU
AccessionPrimary (citable) accession number: Q64658
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families