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Protein

Adenosine kinase

Gene

Adk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Catalytic activityi

ATP + adenosine = ADP + AMP.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenosine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosine kinase (Adk)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenosine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Magnesium 1By similarity1
Metal bindingi147Magnesium 2By similarity1
Active sitei316By similarity1

GO - Molecular functioni

  • adenosine kinase activity Source: RGD
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenosine metabolic process Source: RGD
  • adenosine salvage Source: GO_Central
  • AMP salvage Source: UniProtKB-UniPathway
  • circadian regulation of gene expression Source: RGD
  • positive regulation of cardiac muscle hypertrophy Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • purine ribonucleoside salvage Source: RGD
  • type B pancreatic cell proliferation Source: RGD

Keywordsi

Molecular functionKinase, Transferase
Biological processPurine salvage
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine kinase (EC:2.7.1.20)
Short name:
AK
Alternative name(s):
Adenosine 5'-phosphotransferase
Gene namesi
Name:Adk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2046. Adk.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800551 – 361Adenosine kinaseAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64640.
PRIDEiQ64640.

PTM databases

iPTMnetiQ64640.
PhosphoSitePlusiQ64640.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

MINTiMINT-4566173.
STRINGi10116.ENSRNOP00000016709.

Chemistry databases

BindingDBiQ64640.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNJmodel-A1-361[»]
ProteinModelPortaliQ64640.
SMRiQ64640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 15Nuclear localization signalBy similarity9

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.
HOGENOMiHOG000172419.
HOVERGENiHBG002367.
InParanoidiQ64640.
KOiK00856.
PhylomeDBiQ64640.
TreeFamiTF300745.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiView protein in InterPro
IPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
PfamiView protein in Pfam
PF00294. PfkB. 1 hit.
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiView protein in PROSITE
PS00584. PFKB_KINASES_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAADEPKPK KLKVEAPEAL SENVLFGMGN PLLDISAVVD KDFLDKYSLK
60 70 80 90 100
PNDQILAEDK HKELFDELVK KFKVEYHAGG STQNSMKVAQ WMIQEPHRAA
110 120 130 140 150
TFFGCIGIDK FGEILKSKAA DAHVDAHYYE QNEQPTGTCA ACITGGNRSL
160 170 180 190 200
VANLAAANCY KKEKHLDLEN NWMLVEKARV YYIAGFFLTV SPESVLKVAR
210 220 230 240 250
YAAENNRTFT LNLSAPFISQ FFKEALMEVM PYVDILFGNE TEAATFAREQ
260 270 280 290 300
GFETKDIKEI ARKTQALPKV NSKRQRTVIF TQGRDDTIVA TGNDVTAFPV
310 320 330 340 350
LDQNQEEIVD TNGAGDAFVG GFLSQLVSNK PLTECIRAGH YAASVIIRRT
360
GCTFPEKPDF H
Length:361
Mass (Da):40,134
Last modified:January 9, 2007 - v3
Checksum:i437B83CC56E7A1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121D → N in AAB03110 (PubMed:8917457).Curated1
Sequence conflicti144T → S in AAB03110 (PubMed:8917457).Curated1
Sequence conflicti155A → R in AAB03110 (PubMed:8917457).Curated1
Sequence conflicti198V → M in AAB03110 (PubMed:8917457).Curated1
Sequence conflicti217 – 218FI → LL in AAB03110 (PubMed:8917457).Curated2
Sequence conflicti228E → A in AAB03110 (PubMed:8917457).Curated1
Sequence conflicti359D → N in AAH81712 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90340 mRNA. Translation: AAB50236.1.
BC081712 mRNA. Translation: AAH81712.1.
U57042 mRNA. Translation: AAB03110.1.
PIRiJC5362.
RefSeqiNP_037027.2. NM_012895.3.
UniGeneiRn.64165.

Genome annotation databases

GeneIDi25368.
KEGGirno:25368.
UCSCiRGD:2046. rat.

Similar proteinsi

Entry informationi

Entry nameiADK_RAT
AccessioniPrimary (citable) accession number: Q64640
Secondary accession number(s): O09162, Q642G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families