SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q64638

- UD15_RAT

UniProt

Q64638 - UD15_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

UDP-glucuronosyltransferase 1-5

Gene
Ugt1a5, Ugt1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to ethanol Source: RGD
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. cellular response to hormone stimulus Source: RGD
  4. liver development Source: RGD
  5. response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-5 (EC:2.4.1.17)
Short name:
UDPGT 1-5
Short name:
UGT1*5
Short name:
UGT1-05
Short name:
UGT1.5
Alternative name(s):
B5
UDP-glucuronosyltransferase 1A5
Short name:
UGT1A5
Gene namesi
Name:Ugt1a5
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1583689. Ugt1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50517Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 531506UDP-glucuronosyltransferase 1-5PRO_0000036016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ64638.

Expressioni

Gene expression databases

GenevestigatoriQ64638.

Interactioni

Protein-protein interaction databases

MINTiMINT-3088545.

Structurei

3D structure databases

ProteinModelPortaliQ64638.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64638-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLHVTLQGL AGLLLLLYAL PWAEGGKVLV FPMEGSHWLS MRDVVRELHA    50
RGHQAVVLAP EVTVHIKEED FFTLQTYPVP YTRQGFRQQM MRNIKVVFET 100
GNYVKTFLET SEILKNISTV LLRSCMNLLH NGSLLQHLNS SSFDMVLTDP 150
VIPCGQVLAK YLGIPTVFFL RYIPCGIDSE ATQCPKPSSY IPNLLTMLSD 200
HMTFLQRVKN MLYPLALKYI CHFSFTRYES LASELLQREV SLVEVLSHAS 250
VWLFRGDFVF DYPRPVMPNM VFIGGINCVI KKPLSQEFEA YVNASGEHGI 300
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV 350
KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK 400
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI 450
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H 531
Length:531
Mass (Da):59,993
Last modified:November 1, 1997 - v1
Checksum:i04148C1BA6CAAC80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38069 Genomic DNA. Translation: BAA07263.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38069 Genomic DNA. Translation: BAA07263.1 .
M34007 mRNA. Translation: AAA42312.1 . Different termination.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali Q64638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-3088545.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q64638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1583689. Ugt1a5.

Phylogenomic databases

HOGENOMi HOG000220832.
HOVERGENi HBG004033.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori Q64638.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
    Strain: Wistar.
  2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
    Tissue: Liver.

Entry informationi

Entry nameiUD15_RAT
AccessioniPrimary (citable) accession number: Q64638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi