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Q64637

- UD13_RAT

UniProt

Q64637 - UD13_RAT

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Protein

UDP-glucuronosyltransferase 1-3

Gene
Ugt1a3, Ugt1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. organ regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-3 (EC:2.4.1.17)
Short name:
UDPGT 1-3
Short name:
UGT1*3
Short name:
UGT1-03
Short name:
UGT1.3
Alternative name(s):
B3
UDP-glucuronosyltransferase 1A3
Short name:
UGT1A3
Gene namesi
Name:Ugt1a3
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1549728. Ugt1a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50517Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 531506UDP-glucuronosyltransferase 1-3PRO_0000036014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ64637.

Expressioni

Gene expression databases

GenevestigatoriQ64637.

Structurei

3D structure databases

ProteinModelPortaliQ64637.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64637-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGIQGFLQKL SGLLLLLCAL PWAEGGKVLV FPMEGSHWLS IRDVVRELHA    50
RGHQAVVLAP EVTVHIKEED FFTLQTYPVP YTKEEYRHHL LGHLQNFFET 100
EFSLKLVLQT MAAVNNVSTF YVRSCRGLLH NTALIQSLNS SSFDVVLTDP 150
FFPCGAVLAM YLRVPAVFFL QSMLCELEFE ATNSPNPSSY IPRLLTLNSD 200
HMSFLDRVKN MLYPVPWMYL CHVNYGSLAR LASDLLQREV SVVEILRHAS 250
VWLLRKDFVF HYPRPFMPNM VFIGGINCAN RKPLSQEFEA YVNASGEHGI 300
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV 350
KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK 400
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI 450
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H 531
Length:531
Mass (Da):60,140
Last modified:November 1, 1997 - v1
Checksum:iECB0994C6A2C7CEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38067 Genomic DNA. Translation: BAA07262.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38067 Genomic DNA. Translation: BAA07262.1 .
M34007 mRNA. Translation: AAA42312.1 . Different termination.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali Q64637.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q64637.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1549728. Ugt1a3.

Phylogenomic databases

HOGENOMi HOG000220832.
HOVERGENi HBG004033.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori Q64637.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
    Strain: Wistar.
  2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
    Tissue: Liver.

Entry informationi

Entry nameiUD13_RAT
AccessioniPrimary (citable) accession number: Q64637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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