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Q64637

- UD13_RAT

UniProt

Q64637 - UD13_RAT

Protein

UDP-glucuronosyltransferase 1-3

Gene

Ugt1a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. organ regeneration Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-3 (EC:2.4.1.17)
    Short name:
    UDPGT 1-3
    Short name:
    UGT1*3
    Short name:
    UGT1-03
    Short name:
    UGT1.3
    Alternative name(s):
    B3
    UDP-glucuronosyltransferase 1A3
    Short name:
    UGT1A3
    Gene namesi
    Name:Ugt1a3
    Synonyms:Ugt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1549728. Ugt1a3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 531506UDP-glucuronosyltransferase 1-3PRO_0000036014Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ64637.

    Expressioni

    Gene expression databases

    GenevestigatoriQ64637.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64637.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei489 – 50517HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q64637-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGIQGFLQKL SGLLLLLCAL PWAEGGKVLV FPMEGSHWLS IRDVVRELHA    50
    RGHQAVVLAP EVTVHIKEED FFTLQTYPVP YTKEEYRHHL LGHLQNFFET 100
    EFSLKLVLQT MAAVNNVSTF YVRSCRGLLH NTALIQSLNS SSFDVVLTDP 150
    FFPCGAVLAM YLRVPAVFFL QSMLCELEFE ATNSPNPSSY IPRLLTLNSD 200
    HMSFLDRVKN MLYPVPWMYL CHVNYGSLAR LASDLLQREV SVVEILRHAS 250
    VWLLRKDFVF HYPRPFMPNM VFIGGINCAN RKPLSQEFEA YVNASGEHGI 300
    VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV 350
    KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK 400
    RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI 450
    EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
    VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H 531
    Length:531
    Mass (Da):60,140
    Last modified:November 1, 1997 - v1
    Checksum:iECB0994C6A2C7CEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38067 Genomic DNA. Translation: BAA07262.1.
    M34007 mRNA. Translation: AAA42312.1. Different termination.
    UniGeneiRn.26489.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38067 Genomic DNA. Translation: BAA07262.1 .
    M34007 mRNA. Translation: AAA42312.1 . Different termination.
    UniGenei Rn.26489.

    3D structure databases

    ProteinModelPortali Q64637.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi Q64637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 1549728. Ugt1a3.

    Phylogenomic databases

    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Gene expression databases

    Genevestigatori Q64637.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
      Emi Y., Ikushiro S., Iyanagi T.
      J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
      Strain: Wistar.
    2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
      Sato H., Koiwai O., Tanabe K., Kashiwamata S.
      Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
      Tissue: Liver.

    Entry informationi

    Entry nameiUD13_RAT
    AccessioniPrimary (citable) accession number: Q64637
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3