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Q64637 (UD13_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-3

Short name=UDPGT 1-3
Short name=UGT1*3
Short name=UGT1-03
Short name=UGT1.3
EC=2.4.1.17
Alternative name(s):
B3
UDP-glucuronosyltransferase 1A3
Short name=UGT1A3
Gene names
Name:Ugt1a3
Synonyms:Ugt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q64637-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 531506UDP-glucuronosyltransferase 1-3
PRO_0000036014

Regions

Transmembrane489 – 50517Helical; Potential

Amino acid modifications

Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: ECB0994C6A2C7CEF

FASTA53160,140
        10         20         30         40         50         60 
MGIQGFLQKL SGLLLLLCAL PWAEGGKVLV FPMEGSHWLS IRDVVRELHA RGHQAVVLAP 

        70         80         90        100        110        120 
EVTVHIKEED FFTLQTYPVP YTKEEYRHHL LGHLQNFFET EFSLKLVLQT MAAVNNVSTF 

       130        140        150        160        170        180 
YVRSCRGLLH NTALIQSLNS SSFDVVLTDP FFPCGAVLAM YLRVPAVFFL QSMLCELEFE 

       190        200        210        220        230        240 
ATNSPNPSSY IPRLLTLNSD HMSFLDRVKN MLYPVPWMYL CHVNYGSLAR LASDLLQREV 

       250        260        270        280        290        300 
SVVEILRHAS VWLLRKDFVF HYPRPFMPNM VFIGGINCAN RKPLSQEFEA YVNASGEHGI 

       310        320        330        340        350        360 
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV KWLPQNDLLG 

       370        380        390        400        410        420 
HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 

       430        440        450        460        470        480 
LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 

       490        500        510        520        530 
WYQYHSLDVI GFLLAIVLTV VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H 

« Hide

References

[1]"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
Emi Y., Ikushiro S., Iyanagi T.
J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
Strain: Wistar.
[2]"Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
Sato H., Koiwai O., Tanabe K., Kashiwamata S.
Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38067 Genomic DNA. Translation: BAA07262.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneRn.26489.

3D structure databases

ProteinModelPortalQ64637.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEQ64637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD1549728. Ugt1a3.

Phylogenomic databases

HOGENOMHOG000220832.
HOVERGENHBG004033.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorQ64637.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD13_RAT
AccessionPrimary (citable) accession number: Q64637
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families