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Q64634 (UD18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-8

Short name=UDPGT 1-8
Short name=UGT1*8
Short name=UGT1-08
Short name=UGT1.8
EC=2.4.1.17
Alternative name(s):
A3
UDP-glucuronosyltransferase 1A8
Short name=UGT1A8
Gene names
Name:Ugt1a8
Synonyms:Ugt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q64634-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 530505UDP-glucuronosyltransferase 1-8
PRO_0000036022

Regions

Transmembrane488 – 50417Helical; Potential

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation2921N-linked (GlcNAc...) Potential
Glycosylation4301N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 507098AE81D4AC5C

FASTA53060,060
        10         20         30         40         50         60 
MAPSGCPPSL PLCVCLFLAS GFAQAGRLLV VPMDGSHWFT MQMIVEKLSH RGHEVVVVIP 

        70         80         90        100        110        120 
EVSWHMGKSL NFTVKLLLVL NTLEDLNYHF KFFAHNQWKT QEVGMFSLLK HSGKGFFELL 

       130        140        150        160        170        180 
FSHCRSLFKD KKLVEYLKQS SFDAVFLDPF DVCGLILAKY FSLPSVVFSG GIFCHYLDEG 

       190        200        210        220        230        240 
AQCPSPPSYV PRILSKFTDT MTFKERVWNH LSYMKERAFC PYFFKTAVEI ASEVLQTPVT 

       250        260        270        280        290        300 
MRDLFSPVSI WMFRTDFVLE FPRPMMPNMV YIGGINCHQG KPLSKEFEAY VNASGEHGIV 

       310        320        330        340        350        360 
VFSLGSMVSE IPEKKAMEIA EALGRIPQTL LWRYTGTRPS NLAKNTILVK WLPQNDLLGH 

       370        380        390        400        410        420 
PKARAFITHS GSHGIYEGIC NGVPMVMMPL FGDQMDNAKR METRGAGVTL NVLEMTADDL 

       430        440        450        460        470        480 
ENALKTVINN KSYKENIMRL SSLHKDRPIE PLDLAVFWVE YVMRHKGAPH LRPAAHDLTW 

       490        500        510        520        530 
YQYHSLDVIG FLLAIVLTVV FIVYKSCAYG CRKCFGGKGR VKKSHKSKTH 

« Hide

References

[1]"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
Emi Y., Ikushiro S., Iyanagi T.
J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
[2]"Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
Sato H., Koiwai O., Tanabe K., Kashiwamata S.
Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-530.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38063 Genomic DNA. Translation: BAA07259.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneRn.26489.

3D structure databases

ProteinModelPortalQ64634.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEQ64634.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:708474. rat. [Q64634-1]

Organism-specific databases

RGD708474. Ugt1a8.

Phylogenomic databases

HOGENOMHOG000220832.
HOVERGENHBG004033.
PhylomeDBQ64634.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorQ64634.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD18_RAT
AccessionPrimary (citable) accession number: Q64634
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families