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Q64634

- UD18_RAT

UniProt

Q64634 - UD18_RAT

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Protein

UDP-glucuronosyltransferase 1-8

Gene

Ugt1a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD

GO - Biological processi

  1. cellular response to organic cyclic compound Source: RGD
  2. coumarin catabolic process Source: RGD
  3. protein glucuronidation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-8 (EC:2.4.1.17)
Short name:
UDPGT 1-8
Short name:
UGT1*8
Short name:
UGT1-08
Short name:
UGT1.8
Alternative name(s):
A3
UDP-glucuronosyltransferase 1A8
Short name:
UGT1A8
Gene namesi
Name:Ugt1a8
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708474. Ugt1a8.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 530505UDP-glucuronosyltransferase 1-8PRO_0000036022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ64634.

Expressioni

Gene expression databases

GenevestigatoriQ64634.

Structurei

3D structure databases

ProteinModelPortaliQ64634.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei488 – 50417HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ64634.
PhylomeDBiQ64634.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64634) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSGCPPSL PLCVCLFLAS GFAQAGRLLV VPMDGSHWFT MQMIVEKLSH
60 70 80 90 100
RGHEVVVVIP EVSWHMGKSL NFTVKLLLVL NTLEDLNYHF KFFAHNQWKT
110 120 130 140 150
QEVGMFSLLK HSGKGFFELL FSHCRSLFKD KKLVEYLKQS SFDAVFLDPF
160 170 180 190 200
DVCGLILAKY FSLPSVVFSG GIFCHYLDEG AQCPSPPSYV PRILSKFTDT
210 220 230 240 250
MTFKERVWNH LSYMKERAFC PYFFKTAVEI ASEVLQTPVT MRDLFSPVSI
260 270 280 290 300
WMFRTDFVLE FPRPMMPNMV YIGGINCHQG KPLSKEFEAY VNASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMEIA EALGRIPQTL LWRYTGTRPS NLAKNTILVK
360 370 380 390 400
WLPQNDLLGH PKARAFITHS GSHGIYEGIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METRGAGVTL NVLEMTADDL ENALKTVINN KSYKENIMRL SSLHKDRPIE
460 470 480 490 500
PLDLAVFWVE YVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAIVLTVV
510 520 530
FIVYKSCAYG CRKCFGGKGR VKKSHKSKTH
Length:530
Mass (Da):60,060
Last modified:November 1, 1997 - v1
Checksum:i507098AE81D4AC5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38063 Genomic DNA. Translation: BAA07259.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

Genome annotation databases

UCSCiRGD:708474. rat. [Q64634-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38063 Genomic DNA. Translation: BAA07259.1 .
M34007 mRNA. Translation: AAA42312.1 . Different termination.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali Q64634.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q64634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:708474. rat. [Q64634-1 ]

Organism-specific databases

RGDi 708474. Ugt1a8.

Phylogenomic databases

HOGENOMi HOG000220832.
HOVERGENi HBG004033.
InParanoidi Q64634.
PhylomeDBi Q64634.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori Q64634.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-530.
    Tissue: Liver.

Entry informationi

Entry nameiUD18_RAT
AccessioniPrimary (citable) accession number: Q64634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3