Reviewed, UniProtKB/Swiss-Prot Q64634 (UD18_RAT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-8
      Short name=UDPGT
      Short name=UGT1*8
    EC=2.4.1.17
Alternative name(s):
    UGT1-08
      Short name=UGT1.8
    UGT1A8
    A3

Gene names

Name:

Ugt1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64634-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 530	505	UDP-glucuronosyltransferase 1-8		PRO_0000036022
Regions
	Transmembrane	488 – 504	17	Potential
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	292	1	N-linked (GlcNAc...) Potential
	Glycosylation	430	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 507098AE81D4AC5C	FASTA	530	60,060
	10 20 30 40 50 60 MAPSGCPPSL PLCVCLFLAS GFAQAGRLLV VPMDGSHWFT MQMIVEKLSH RGHEVVVVIP 70 80 90 100 110 120 EVSWHMGKSL NFTVKLLLVL NTLEDLNYHF KFFAHNQWKT QEVGMFSLLK HSGKGFFELL 130 140 150 160 170 180 FSHCRSLFKD KKLVEYLKQS SFDAVFLDPF DVCGLILAKY FSLPSVVFSG GIFCHYLDEG 190 200 210 220 230 240 AQCPSPPSYV PRILSKFTDT MTFKERVWNH LSYMKERAFC PYFFKTAVEI ASEVLQTPVT 250 260 270 280 290 300 MRDLFSPVSI WMFRTDFVLE FPRPMMPNMV YIGGINCHQG KPLSKEFEAY VNASGEHGIV 310 320 330 340 350 360 VFSLGSMVSE IPEKKAMEIA EALGRIPQTL LWRYTGTRPS NLAKNTILVK WLPQNDLLGH 370 380 390 400 410 420 PKARAFITHS GSHGIYEGIC NGVPMVMMPL FGDQMDNAKR METRGAGVTL NVLEMTADDL 430 440 450 460 470 480 ENALKTVINN KSYKENIMRL SSLHKDRPIE PLDLAVFWVE YVMRHKGAPH LRPAAHDLTW 490 500 510 520 530 YQYHSLDVIG FLLAIVLTVV FIVYKSCAYG CRKCFGGKGR VKKSHKSKTH

References

[1]	"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex." Emi Y., Ikushiro S., Iyanagi T. J. Biochem. 117:392-399(1995) [PubMed: 7608130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Wistar.
[2]	"Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript." Sato H., Koiwai O., Tanabe K., Kashiwamata S. Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed: 2112380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-530. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D38063 Genomic DNA. Translation: BAA07259.1. M34007 mRNA. Translation: AAA42312.1. Different termination.
IPI	IPI00475998.
UniGene	Rn.26489
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSRNOG00000018740. Rattus norvegicus. [Contig view]
Phylogenomic databases
HOVERGEN	Q64634.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	Q64634.
GermOnline	ENSRNOG00000018740. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD18_RAT

Accession

Primary (citable) accession number: Q64634

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)