SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q64633

- UD17_RAT

UniProt

Q64633 - UD17_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UDP-glucuronosyltransferase 1-7
Gene
Ugt1a7c, Ugt1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD

GO - Biological processi

  1. aromatic compound catabolic process Source: RGD
  2. coumarin catabolic process Source: RGD
  3. estrogen catabolic process Source: RGD
  4. liver development Source: RGD
  5. response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-7 (EC:2.4.1.17)
Short name:
UDPGT 1-7
Short name:
UGT1*7
Short name:
UGT1-07
Short name:
UGT1.7
Alternative name(s):
A2
UDP-glucuronosyltransferase 1A7C
UGT1A7
Gene namesi
Name:Ugt1a7c
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620950. Ugt1a7c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 50317Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 531506UDP-glucuronosyltransferase 1-7
PRO_0000036021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ64633.

Expressioni

Gene expression databases

GenevestigatoriQ64633.

Interactioni

Protein-protein interaction databases

MINTiMINT-4570127.

Structurei

3D structure databases

ProteinModelPortaliQ64633.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64633-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPADVPASL PLGLCLLLAS GFGHAGKLLV VPMDGSHWFT MQMVVEKLLP    50
KGHEVVVVVP EVSWQLGKPL NFTVKTYSVS HTQEDLNREF KFFIDSQWKT 100
QQESGVLPLL TSPAQGFFEL LFSHCRSLFK DKKLVEYLKQ SSFDAVFLDP 150
FDVCGLTVAK YFSLPSVVFS RGIFCHYLEE GSQCPSPPSY VPRPILKLTD 200
TMTFKERVWN LLSYMGEHAF CPSFFKTATD IASEVLQTPV TMTDLFSPVS 250
VWLLRTDFTL ELPRPVMPNV IHIGGINCHQ RKPVSKEFEA YVNASGEHGI 300
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV 350
KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK 400
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI 450
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H 531
Length:531
Mass (Da):59,627
Last modified:November 1, 1997 - v1
Checksum:iBC791DCE724CA621
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38062 Genomic DNA. Translation: BAA07258.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

Genome annotation databases

UCSCiRGD:620950. rat. [Q64633-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38062 Genomic DNA. Translation: BAA07258.1 .
M34007 mRNA. Translation: AAA42312.1 . Different termination.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali Q64633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4570127.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q64633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620950. rat. [Q64633-1 ]

Organism-specific databases

RGDi 620950. Ugt1a7c.

Phylogenomic databases

HOVERGENi HBG004033.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori Q64633.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
    Strain: Wistar.
  2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
    Tissue: Liver.

Entry informationi

Entry nameiUD17_RAT
AccessioniPrimary (citable) accession number: Q64633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi