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Protein

UDP-glucuronosyltransferase 1-7

Gene

Ugt1a7c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD

GO - Biological processi

  1. aromatic compound catabolic process Source: RGD
  2. cellular response to hormone stimulus Source: GO_Central
  3. coumarin catabolic process Source: RGD
  4. estrogen catabolic process Source: RGD
  5. flavonoid biosynthetic process Source: GO_Central
  6. flavonoid glucuronidation Source: GO_Central
  7. liver development Source: RGD
  8. response to organic cyclic compound Source: RGD
  9. xenobiotic glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-7 (EC:2.4.1.17)
Short name:
UDPGT 1-7
Short name:
UGT1*7
Short name:
UGT1-07
Short name:
UGT1.7
Alternative name(s):
A2
UDP-glucuronosyltransferase 1A7C
UGT1A7
Gene namesi
Name:Ugt1a7c
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620950. Ugt1a7c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 50317HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: GO_Central
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 531506UDP-glucuronosyltransferase 1-7PRO_0000036021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ64633.

Expressioni

Gene expression databases

GenevestigatoriQ64633.

Interactioni

Protein-protein interaction databases

MINTiMINT-4570127.

Structurei

3D structure databases

ProteinModelPortaliQ64633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ64633.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPADVPASL PLGLCLLLAS GFGHAGKLLV VPMDGSHWFT MQMVVEKLLP
60 70 80 90 100
KGHEVVVVVP EVSWQLGKPL NFTVKTYSVS HTQEDLNREF KFFIDSQWKT
110 120 130 140 150
QQESGVLPLL TSPAQGFFEL LFSHCRSLFK DKKLVEYLKQ SSFDAVFLDP
160 170 180 190 200
FDVCGLTVAK YFSLPSVVFS RGIFCHYLEE GSQCPSPPSY VPRPILKLTD
210 220 230 240 250
TMTFKERVWN LLSYMGEHAF CPSFFKTATD IASEVLQTPV TMTDLFSPVS
260 270 280 290 300
VWLLRTDFTL ELPRPVMPNV IHIGGINCHQ RKPVSKEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT LLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):59,627
Last modified:November 1, 1997 - v1
Checksum:iBC791DCE724CA621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38062 Genomic DNA. Translation: BAA07258.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

Genome annotation databases

UCSCiRGD:620950. rat. [Q64633-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38062 Genomic DNA. Translation: BAA07258.1.
M34007 mRNA. Translation: AAA42312.1. Different termination.
UniGeneiRn.26489.

3D structure databases

ProteinModelPortaliQ64633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4570127.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiQ64633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620950. rat. [Q64633-1]

Organism-specific databases

RGDi620950. Ugt1a7c.

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ64633.

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Gene expression databases

GenevestigatoriQ64633.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-286.
    Strain: Wistar.
  2. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-531.
    Tissue: Liver.

Entry informationi

Entry nameiUD17_RAT
AccessioniPrimary (citable) accession number: Q64633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.