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Q64632

- ITB4_RAT

UniProt

Q64632 - ITB4_RAT

Protein

Integrin beta-4

Gene

Itgb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility By similarity.By similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: RGD
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. cell-matrix adhesion Source: InterPro
    3. cell motility Source: UniProtKB
    4. hemidesmosome assembly Source: InterPro
    5. integrin-mediated signaling pathway Source: RGD
    6. multicellular organismal development Source: InterPro
    7. response to wounding Source: UniProtKB

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin beta-4
    Alternative name(s):
    GP150
    CD_antigen: CD104
    Gene namesi
    Name:Itgb4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2928. Itgb4.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell membrane By similarity; Lipid-anchor By similarity. Cell junctionhemidesmosome By similarity
    Note: Colocalizes with DST at the leading edge of migrating keratinocytes.By similarity

    GO - Cellular componenti

    1. cell cortex Source: RGD
    2. cell leading edge Source: UniProtKB
    3. cytoplasm Source: RGD
    4. extracellular space Source: RGD
    5. hemidesmosome Source: UniProtKB-SubCell
    6. integral component of membrane Source: RGD
    7. integrin complex Source: RGD
    8. membrane Source: RGD

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 18071780Integrin beta-4PRO_0000016347Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 456By similarity
    Disulfide bondi38 ↔ 48By similarity
    Disulfide bondi41 ↔ 72By similarity
    Disulfide bondi51 ↔ 61By similarity
    Disulfide bondi245 ↔ 288By similarity
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi424 ↔ 673By similarity
    Disulfide bondi453 ↔ 458By similarity
    Disulfide bondi469 ↔ 480By similarity
    Disulfide bondi477 ↔ 513By similarity
    Disulfide bondi482 ↔ 491By similarity
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi493 ↔ 504By similarity
    Disulfide bondi519 ↔ 524By similarity
    Disulfide bondi521 ↔ 552By similarity
    Disulfide bondi526 ↔ 537By similarity
    Disulfide bondi558 ↔ 563By similarity
    Disulfide bondi565 ↔ 574By similarity
    Disulfide bondi576 ↔ 583By similarity
    Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi597 ↔ 602By similarity
    Disulfide bondi599 ↔ 650By similarity
    Disulfide bondi604 ↔ 616By similarity
    Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi628 ↔ 637By similarity
    Disulfide bondi634 ↔ 708By similarity
    Disulfide bondi653 ↔ 682By similarity
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1514 – 15141PhosphothreonineBy similarity

    Post-translational modificationi

    Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiQ64632.
    PRIDEiQ64632.

    PTM databases

    PhosphoSiteiQ64632.

    Expressioni

    Gene expression databases

    GenevestigatoriQ64632.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048660.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64632.
    SMRiQ64632. Positions 1128-1322, 1504-1606.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 713686ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini735 – 18071073CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei714 – 73421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 7345PSIAdd
    BLAST
    Domaini131 – 340210VWFAAdd
    BLAST
    Repeati457 – 50347IAdd
    BLAST
    Repeati504 – 54340IIAdd
    BLAST
    Repeati544 – 58239IIIAdd
    BLAST
    Repeati583 – 62139IVAdd
    BLAST
    Domaini981 – 1086106Calx-betaAdd
    BLAST
    Domaini1131 – 122090Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1224 – 1323100Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1514 – 160996Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1627 – 172397Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni457 – 621165Cysteine-rich tandem repeatsAdd
    BLAST
    Regioni734 – 75118Palmitoylated on several cysteinesBy similarityAdd
    BLAST

    Domaini

    The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.

    Sequence similaritiesi

    Belongs to the integrin beta chain family.Curated
    Contains 1 Calx-beta domain.Curated
    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 PSI domain.Curated
    Contains 1 VWFA domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303049.
    HOGENOMiHOG000231105.
    HOVERGENiHBG006189.
    InParanoidiQ64632.
    KOiK06525.
    PhylomeDBiQ64632.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.40.50.410. 1 hit.
    InterProiIPR003644. Calx_beta.
    IPR013032. EGF-like_CS.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015812. Integrin_bsu.
    IPR012013. Integrin_bsu-4.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF6. PTHR10082:SF6. 1 hit.
    PfamiPF03160. Calx-beta. 1 hit.
    PF00041. fn3. 4 hits.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002513. Integrin_B4. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00237. Calx_beta. 1 hit.
    SM00060. FN3. 4 hits.
    SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF49265. SSF49265. 2 hits.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50853. FN3. 4 hits.
    PS00243. INTEGRIN_BETA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64632-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLCSSPWV KLLLAVVLSA GLPGNMANRC KKAQVKSCTE CIRVDKSCAY     50
    CTDELFKERR CNTQADVLAA GCRGESVLVM ESSLEITENI QIDTSLHRSQ 100
    VSPQGLQVRL RPGEERNFVF KVFEPLESPV DLYILMDFSN SMSDDLDNLK 150
    QMGQNLAKIL RQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP 200
    FSFKNVISLT ENVEEFWDKL QGERISGNLD APEGGFDAIL QTAVCTRDIG 250
    WRADSTHLLV FSTESAFHYE ADGANVLAGI MNRNDEKCHL DATGAYTQYK 300
    TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHKYF PVSSLGVLQE 350
    DSSNIVELLE EAFYRIRSNL DIRALDSPRG LRTEVTSDTL QKTETGSFHI 400
    KRGEVGTYNV HLRAVEDIDG THVCQLAKED QRGNIHLKPS FSDGLRMDAS 450
    VICDMCACEL QKEVQSARCH YRGDFMCGHC VCNEGWSGKT CNCSTGSLSD 500
    TQPCLREGED KPCSGHGECQ CGRCVCYGEG RYEGHFCEYD NFQCPRTSGF 550
    LCNDRGRCSM GECVCEPGWT GRSCDCPLSN ATCIDSNGGI CNGLGFCECG 600
    RCHCNQRSSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRTC 650
    EECNFKVKMV DELKKAEEVV EYCSFRDEDD DCTYSYTVEG DGSPGPNSTV 700
    LVHKKKDCLP APSWWLIPLL IFLLLLLVLL LLLCWKYCAC CKACLGLLPC 750
    CNQGHMVGFK EDHYMLRENL MASDHLDTPM LRSGNLKGRD TVRWKITNNV 800
    QRPGFATHAA SISPTELVPY GLSLRLGRLC TENLMKPGTR ECDQLRQEVE 850
    ENLNEVYRQV NGVHKLQQTK FRQQPNAGKK QDHTIVDTVL LAPRSAKQSL 900
    LKLTEKQVEQ GSFHELKVAP GYYTLTAEQD ARGMVEFQEG VELVDVRVPL 950
    FIRPEDDDEK QLLVEAIDVP VGTATLGRRL VNITIIKEQA SGIVSFEQPE 1000
    YSVSRGDQVA RIPVIRHILD NGKSQVSYST QDNTAHGHRD YVPVEGELLF 1050
    YPGETWKELQ VKLLELQEVD SLLRGRQVRR FQVQLSNPKF GARLGQPNTA 1100
    TVIIGEQDET DRSLINEISA SPPLPRGDLG APQNPNAKAA GSRKIHFNWL 1150
    PPPGKPMGYR VKYWVQGDSE SEAHLLDSKV PSVELTNLYP YCDYEMKVCA 1200
    YGAHGEGPYS SLVSCRTHQE VPSEPGRLAF NVVSSTVTQL SWAEPAETNG 1250
    EITAYEVCYG LVNEDNRPIG PMKKVLVDNP KNRMLLIENL RESQPYRYTV 1300
    KARNGAGWGP EREAIINLAT QPKRPMSIPI IPDIPIVDAQ GGEDYENFLM 1350
    YSDDVLRSPA SSQRPSVSDD TEHLVNGRMD FAYPGSANSL HRMTAANVAY 1400
    GTHLSPHQTH RMLSTSSTLT RDYHSLTRTD HSQSGTLPRD YSTLTSLSSQ 1450
    GLPPIWEDGR SRLPLSWTLG SWSRAQMKGV PASRGSPDSI ILAGQSAAPS 1500
    WGTDSRGAMG VPDTPTRLVF SALGPTSLKV SWQEPQCDRA LLGYSVEYQL 1550
    LNGGEMHRLN IPNPGQTSVV VEDLLPNHSY VFRVRAQSQE GWGREREGVI 1600
    TIESQVHPQS PLCPLPGSAF TLSTPSAPGP LVFTALSPDS LQLSWERPRR 1650
    PNGDILGYLV TCEMAQGGGP ARTFRVDGDN PESRLTVPGL SENVPYKFKV 1700
    QARTTEGFGP EREGIITIES QDGGPFPQLG SHSGLFQNPL QSEYSTVTST 1750
    HSTTTTEPFL IDGLTLGTQR LEAGGSLTRH VTQEFVSRTL TTSGSLSTHM 1800
    DQQFFQT 1807
    Length:1,807
    Mass (Da):200,589
    Last modified:November 1, 1996 - v1
    Checksum:i2EF9BD4E345829A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60096 mRNA. Translation: AAC53094.1.
    PIRiJC6319.
    RefSeqiNP_037312.1. NM_013180.1.
    UniGeneiRn.198908.

    Genome annotation databases

    GeneIDi25724.
    KEGGirno:25724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60096 mRNA. Translation: AAC53094.1 .
    PIRi JC6319.
    RefSeqi NP_037312.1. NM_013180.1.
    UniGenei Rn.198908.

    3D structure databases

    ProteinModelPortali Q64632.
    SMRi Q64632. Positions 1128-1322, 1504-1606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048660.

    PTM databases

    PhosphoSitei Q64632.

    Proteomic databases

    PaxDbi Q64632.
    PRIDEi Q64632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25724.
    KEGGi rno:25724.

    Organism-specific databases

    CTDi 3691.
    RGDi 2928. Itgb4.

    Phylogenomic databases

    eggNOGi NOG303049.
    HOGENOMi HOG000231105.
    HOVERGENi HBG006189.
    InParanoidi Q64632.
    KOi K06525.
    PhylomeDBi Q64632.

    Miscellaneous databases

    NextBioi 607829.
    PROi Q64632.

    Gene expression databases

    Genevestigatori Q64632.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.40.50.410. 1 hit.
    InterProi IPR003644. Calx_beta.
    IPR013032. EGF-like_CS.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015812. Integrin_bsu.
    IPR012013. Integrin_bsu-4.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF6. PTHR10082:SF6. 1 hit.
    Pfami PF03160. Calx-beta. 1 hit.
    PF00041. fn3. 4 hits.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002513. Integrin_B4. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00237. Calx_beta. 1 hit.
    SM00060. FN3. 4 hits.
    SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF49265. SSF49265. 2 hits.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50853. FN3. 4 hits.
    PS00243. INTEGRIN_BETA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve."
      Feltri M.L., Arona M., Scherer S.S., Wrabetz L.
      Gene 186:299-304(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Sciatic nerve.

    Entry informationi

    Entry nameiITB4_RAT
    AccessioniPrimary (citable) accession number: Q64632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3