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Q64632

- ITB4_RAT

UniProt

Q64632 - ITB4_RAT

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Protein
Integrin beta-4
Gene
Itgb4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility By similarity.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: RGD
  2. receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: RGD
  2. cell motility Source: UniProtKB
  3. cell-matrix adhesion Source: InterPro
  4. hemidesmosome assembly Source: InterPro
  5. integrin-mediated signaling pathway Source: RGD
  6. multicellular organismal development Source: InterPro
  7. response to wounding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-4
Alternative name(s):
GP150
CD_antigen: CD104
Gene namesi
Name:Itgb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2928. Itgb4.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Cell membrane; Lipid-anchor By similarity. Cell junctionhemidesmosome By similarity
Note: Colocalizes with DST at the leading edge of migrating keratinocytes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 713686Extracellular Reviewed prediction
Add
BLAST
Transmembranei714 – 73421Helical; Reviewed prediction
Add
BLAST
Topological domaini735 – 18071073Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell cortex Source: RGD
  2. cell leading edge Source: UniProtKB
  3. cytoplasm Source: RGD
  4. extracellular space Source: RGD
  5. hemidesmosome Source: UniProtKB-SubCell
  6. integral component of membrane Source: RGD
  7. integrin complex Source: RGD
  8. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 By similarity
Add
BLAST
Chaini28 – 18071780Integrin beta-4
PRO_0000016347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 456 By similarity
Disulfide bondi38 ↔ 48 By similarity
Disulfide bondi41 ↔ 72 By similarity
Disulfide bondi51 ↔ 61 By similarity
Disulfide bondi245 ↔ 288 By similarity
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi424 ↔ 673 By similarity
Disulfide bondi453 ↔ 458 By similarity
Disulfide bondi469 ↔ 480 By similarity
Disulfide bondi477 ↔ 513 By similarity
Disulfide bondi482 ↔ 491 By similarity
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi493 ↔ 504 By similarity
Disulfide bondi519 ↔ 524 By similarity
Disulfide bondi521 ↔ 552 By similarity
Disulfide bondi526 ↔ 537 By similarity
Disulfide bondi558 ↔ 563 By similarity
Disulfide bondi565 ↔ 574 By similarity
Disulfide bondi576 ↔ 583 By similarity
Glycosylationi580 – 5801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi597 ↔ 602 By similarity
Disulfide bondi599 ↔ 650 By similarity
Disulfide bondi604 ↔ 616 By similarity
Glycosylationi619 – 6191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi628 ↔ 637 By similarity
Disulfide bondi634 ↔ 708 By similarity
Disulfide bondi653 ↔ 682 By similarity
Glycosylationi697 – 6971N-linked (GlcNAc...) Reviewed prediction
Modified residuei1514 – 15141Phosphothreonine By similarity

Post-translational modificationi

Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ64632.
PRIDEiQ64632.

PTM databases

PhosphoSiteiQ64632.

Expressioni

Gene expression databases

GenevestigatoriQ64632.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048660.

Structurei

3D structure databases

ProteinModelPortaliQ64632.
SMRiQ64632. Positions 1128-1322, 1504-1606.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 7345PSI
Add
BLAST
Domaini131 – 340210VWFA
Add
BLAST
Repeati457 – 50347I
Add
BLAST
Repeati504 – 54340II
Add
BLAST
Repeati544 – 58239III
Add
BLAST
Repeati583 – 62139IV
Add
BLAST
Domaini981 – 1086106Calx-beta
Add
BLAST
Domaini1131 – 122090Fibronectin type-III 1
Add
BLAST
Domaini1224 – 1323100Fibronectin type-III 2
Add
BLAST
Domaini1514 – 160996Fibronectin type-III 3
Add
BLAST
Domaini1627 – 172397Fibronectin type-III 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 621165Cysteine-rich tandem repeats
Add
BLAST
Regioni734 – 75118Palmitoylated on several cysteines By similarity
Add
BLAST

Domaini

The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.

Sequence similaritiesi

Contains 1 Calx-beta domain.
Contains 1 PSI domain.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303049.
HOGENOMiHOG000231105.
HOVERGENiHBG006189.
InParanoidiQ64632.
KOiK06525.
PhylomeDBiQ64632.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.40.50.410. 1 hit.
InterProiIPR003644. Calx_beta.
IPR013032. EGF-like_CS.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015812. Integrin_bsu.
IPR012013. Integrin_bsu-4.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF6. PTHR10082:SF6. 1 hit.
PfamiPF03160. Calx-beta. 1 hit.
PF00041. fn3. 4 hits.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002513. Integrin_B4. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00237. Calx_beta. 1 hit.
SM00060. FN3. 4 hits.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50853. FN3. 4 hits.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64632-1 [UniParc]FASTAAdd to Basket

« Hide

MAGLCSSPWV KLLLAVVLSA GLPGNMANRC KKAQVKSCTE CIRVDKSCAY     50
CTDELFKERR CNTQADVLAA GCRGESVLVM ESSLEITENI QIDTSLHRSQ 100
VSPQGLQVRL RPGEERNFVF KVFEPLESPV DLYILMDFSN SMSDDLDNLK 150
QMGQNLAKIL RQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP 200
FSFKNVISLT ENVEEFWDKL QGERISGNLD APEGGFDAIL QTAVCTRDIG 250
WRADSTHLLV FSTESAFHYE ADGANVLAGI MNRNDEKCHL DATGAYTQYK 300
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHKYF PVSSLGVLQE 350
DSSNIVELLE EAFYRIRSNL DIRALDSPRG LRTEVTSDTL QKTETGSFHI 400
KRGEVGTYNV HLRAVEDIDG THVCQLAKED QRGNIHLKPS FSDGLRMDAS 450
VICDMCACEL QKEVQSARCH YRGDFMCGHC VCNEGWSGKT CNCSTGSLSD 500
TQPCLREGED KPCSGHGECQ CGRCVCYGEG RYEGHFCEYD NFQCPRTSGF 550
LCNDRGRCSM GECVCEPGWT GRSCDCPLSN ATCIDSNGGI CNGLGFCECG 600
RCHCNQRSSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRTC 650
EECNFKVKMV DELKKAEEVV EYCSFRDEDD DCTYSYTVEG DGSPGPNSTV 700
LVHKKKDCLP APSWWLIPLL IFLLLLLVLL LLLCWKYCAC CKACLGLLPC 750
CNQGHMVGFK EDHYMLRENL MASDHLDTPM LRSGNLKGRD TVRWKITNNV 800
QRPGFATHAA SISPTELVPY GLSLRLGRLC TENLMKPGTR ECDQLRQEVE 850
ENLNEVYRQV NGVHKLQQTK FRQQPNAGKK QDHTIVDTVL LAPRSAKQSL 900
LKLTEKQVEQ GSFHELKVAP GYYTLTAEQD ARGMVEFQEG VELVDVRVPL 950
FIRPEDDDEK QLLVEAIDVP VGTATLGRRL VNITIIKEQA SGIVSFEQPE 1000
YSVSRGDQVA RIPVIRHILD NGKSQVSYST QDNTAHGHRD YVPVEGELLF 1050
YPGETWKELQ VKLLELQEVD SLLRGRQVRR FQVQLSNPKF GARLGQPNTA 1100
TVIIGEQDET DRSLINEISA SPPLPRGDLG APQNPNAKAA GSRKIHFNWL 1150
PPPGKPMGYR VKYWVQGDSE SEAHLLDSKV PSVELTNLYP YCDYEMKVCA 1200
YGAHGEGPYS SLVSCRTHQE VPSEPGRLAF NVVSSTVTQL SWAEPAETNG 1250
EITAYEVCYG LVNEDNRPIG PMKKVLVDNP KNRMLLIENL RESQPYRYTV 1300
KARNGAGWGP EREAIINLAT QPKRPMSIPI IPDIPIVDAQ GGEDYENFLM 1350
YSDDVLRSPA SSQRPSVSDD TEHLVNGRMD FAYPGSANSL HRMTAANVAY 1400
GTHLSPHQTH RMLSTSSTLT RDYHSLTRTD HSQSGTLPRD YSTLTSLSSQ 1450
GLPPIWEDGR SRLPLSWTLG SWSRAQMKGV PASRGSPDSI ILAGQSAAPS 1500
WGTDSRGAMG VPDTPTRLVF SALGPTSLKV SWQEPQCDRA LLGYSVEYQL 1550
LNGGEMHRLN IPNPGQTSVV VEDLLPNHSY VFRVRAQSQE GWGREREGVI 1600
TIESQVHPQS PLCPLPGSAF TLSTPSAPGP LVFTALSPDS LQLSWERPRR 1650
PNGDILGYLV TCEMAQGGGP ARTFRVDGDN PESRLTVPGL SENVPYKFKV 1700
QARTTEGFGP EREGIITIES QDGGPFPQLG SHSGLFQNPL QSEYSTVTST 1750
HSTTTTEPFL IDGLTLGTQR LEAGGSLTRH VTQEFVSRTL TTSGSLSTHM 1800
DQQFFQT 1807
Length:1,807
Mass (Da):200,589
Last modified:November 1, 1996 - v1
Checksum:i2EF9BD4E345829A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60096 mRNA. Translation: AAC53094.1.
PIRiJC6319.
RefSeqiNP_037312.1. NM_013180.1.
UniGeneiRn.198908.

Genome annotation databases

GeneIDi25724.
KEGGirno:25724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60096 mRNA. Translation: AAC53094.1 .
PIRi JC6319.
RefSeqi NP_037312.1. NM_013180.1.
UniGenei Rn.198908.

3D structure databases

ProteinModelPortali Q64632.
SMRi Q64632. Positions 1128-1322, 1504-1606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048660.

PTM databases

PhosphoSitei Q64632.

Proteomic databases

PaxDbi Q64632.
PRIDEi Q64632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25724.
KEGGi rno:25724.

Organism-specific databases

CTDi 3691.
RGDi 2928. Itgb4.

Phylogenomic databases

eggNOGi NOG303049.
HOGENOMi HOG000231105.
HOVERGENi HBG006189.
InParanoidi Q64632.
KOi K06525.
PhylomeDBi Q64632.

Miscellaneous databases

NextBioi 607829.
PROi Q64632.

Gene expression databases

Genevestigatori Q64632.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.40.50.410. 1 hit.
InterProi IPR003644. Calx_beta.
IPR013032. EGF-like_CS.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015812. Integrin_bsu.
IPR012013. Integrin_bsu-4.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF6. PTHR10082:SF6. 1 hit.
Pfami PF03160. Calx-beta. 1 hit.
PF00041. fn3. 4 hits.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002513. Integrin_B4. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00237. Calx_beta. 1 hit.
SM00060. FN3. 4 hits.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS50853. FN3. 4 hits.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve."
    Feltri M.L., Arona M., Scherer S.S., Wrabetz L.
    Gene 186:299-304(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Sciatic nerve.

Entry informationi

Entry nameiITB4_RAT
AccessioniPrimary (citable) accession number: Q64632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi