Reviewed, UniProtKB/Swiss-Prot Q64625 (GPX6_RAT)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 6
      Short name=GSHPx-6
      Short name=GPx-6
    EC=1.11.1.9
Alternative name(s):
    Odorant-metabolizing protein RY2D1

Gene names

Name:

Gpx6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted.
Tissue specificity	Expressed in the Bowman glands.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 221	202	Glutathione peroxidase 6		PRO_0000013083
Sites
	Active site	73	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64625-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 92749EAF6A3EF48C	FASTA	221	24,961
	10 20 30 40 50 60 MTQQFWGPCL FSLFMAVLAQ ETLDPQKSKV DCNKGVAGTV YEYGANTLDG GEYVQFQQYA 70 80 90 100 110 120 GKHILFVNVA SFCGLTATYP ELNTLQEELR PFNVSVLGFP CNQFGKQEPG KNSEILLGLK 130 140 150 160 170 180 YVRPGGGFVP NFQLFEKGDV NGDNEQKVFS FLKSSCPPTS ELLGSPEHLF WDPMKVHDIR 190 200 210 220 WNFEKFLVGP DGAPVMRWFH QTPVRVVQSD IMEYLNQTRT Q

References

[1]	"Molecular cloning of putative odorant-binding and odorant-metabolizing proteins." Dear T.N., Campbell K., Rabbitts T.H. Biochemistry 30:10376-10382(1991) [PubMed: 1931961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76733 mRNA. Translation: AAA42094.1.
IPI	IPI00214419.
PIR	B40464.
RefSeq	NP_671694.1.
UniGene	Rn.9852
3D structure databases
SMR	Q64625. Positions 36-217.
ModBase	Search...
Protein family/group databases
PeroxiBase	3736. RnoGPx06.
Genome annotation databases
GeneID	259233.
KEGG	rno:259233.
Organism-specific databases
CTD	259233.
RGD	628789. Gpx6.
Phylogenomic databases
eggNOG	roNOG06842.
HOVERGEN	Q64625.
Enzyme and pathway databases
BRENDA	1.11.1.9. 248.
Gene expression databases
Genevestigator	Q64625.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	624260.

Entry information

Entry name

GPX6_RAT

Accession

Primary (citable) accession number: Q64625

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)