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Protein

Glutathione peroxidase 6

Gene

Gpx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3736. RnoGPx06.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 6 (EC:1.11.1.9)
Short name:
GPx-6
Short name:
GSHPx-6
Alternative name(s):
Odorant-metabolizing protein RY2D1
Gene namesi
Name:Gpx6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628789. Gpx6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001308320 – 221Glutathione peroxidase 6Add BLAST202

Proteomic databases

PaxDbiQ64625.
PRIDEiQ64625.

Expressioni

Tissue specificityi

Expressed in the Bowman glands.

Gene expression databases

BgeeiENSRNOG00000018473.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055070.

Structurei

3D structure databases

ProteinModelPortaliQ64625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
HOVERGENiHBG004333.
InParanoidiQ64625.
KOiK00432.
PhylomeDBiQ64625.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQFWGPCL FSLFMAVLAQ ETLDPQKSKV DCNKGVAGTV YEYGANTLDG
60 70 80 90 100
GEYVQFQQYA GKHILFVNVA SFCGLTATYP ELNTLQEELR PFNVSVLGFP
110 120 130 140 150
CNQFGKQEPG KNSEILLGLK YVRPGGGFVP NFQLFEKGDV NGDNEQKVFS
160 170 180 190 200
FLKSSCPPTS ELLGSPEHLF WDPMKVHDIR WNFEKFLVGP DGAPVMRWFH
210 220
QTPVRVVQSD IMEYLNQTRT Q
Length:221
Mass (Da):24,961
Last modified:November 1, 1996 - v1
Checksum:i92749EAF6A3EF48C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76733 mRNA. Translation: AAA42094.1.
PIRiB40464.
RefSeqiNP_671694.1. NM_147165.1.
UniGeneiRn.9852.

Genome annotation databases

GeneIDi259233.
KEGGirno:259233.
UCSCiRGD:628789. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76733 mRNA. Translation: AAA42094.1.
PIRiB40464.
RefSeqiNP_671694.1. NM_147165.1.
UniGeneiRn.9852.

3D structure databases

ProteinModelPortaliQ64625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055070.

Protein family/group databases

PeroxiBasei3736. RnoGPx06.

Proteomic databases

PaxDbiQ64625.
PRIDEiQ64625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi259233.
KEGGirno:259233.
UCSCiRGD:628789. rat.

Organism-specific databases

CTDi257202.
RGDi628789. Gpx6.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
HOVERGENiHBG004333.
InParanoidiQ64625.
KOiK00432.
PhylomeDBiQ64625.

Miscellaneous databases

PROiQ64625.

Gene expression databases

BgeeiENSRNOG00000018473.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX6_RAT
AccessioniPrimary (citable) accession number: Q64625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.