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Q64620

- PPP6_RAT

UniProt

Q64620 - PPP6_RAT

Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

Ppp6c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi81 – 811Manganese 2By similarity
    Metal bindingi113 – 1131Manganese 2By similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi163 – 1631Manganese 2By similarity
    Metal bindingi237 – 2371Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: RGD

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. protein dephosphorylation Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
    Short name:
    PP6C
    Alternative name(s):
    Protein phosphatase V
    Short name:
    PP-V
    Cleaved into the following chain:
    Gene namesi
    Name:Ppp6c
    Synonyms:Ppv
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi708460. Ppp6c.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Serine/threonine-protein phosphatase 6 catalytic subunitPRO_0000058879Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 305304Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processedPRO_0000424506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ64620.

    PTM databases

    PhosphoSiteiQ64620.

    Expressioni

    Tissue specificityi

    Highest levels found in spleen, brain and lung.1 Publication

    Gene expression databases

    GenevestigatoriQ64620.

    Interactioni

    Subunit structurei

    Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ64620. 2 interactions.
    STRINGi10116.ENSRNOP00000021176.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64620.
    SMRiQ64620. Positions 5-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00550000074961.
    HOGENOMiHOG000172696.
    HOVERGENiHBG000216.
    InParanoidiQ64620.
    KOiK15498.
    OMAiVPETSYI.
    OrthoDBiEOG74N5H2.
    PhylomeDBiQ64620.
    TreeFamiTF105563.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64620-1 [UniParc]FASTAAdd to Basket

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    MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV    50
    CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK 100
    AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT 150
    VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE 200
    DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE 250
    KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 300
    TPYFL 305
    Length:305
    Mass (Da):35,159
    Last modified:January 15, 2008 - v2
    Checksum:i662969DE1B2EF490
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721P → L in CAA54453. (PubMed:8077208)Curated
    Sequence conflicti87 – 871Y → H in CAA54453. (PubMed:8077208)Curated
    Sequence conflicti91 – 911E → V in CAA54453. (PubMed:8077208)Curated
    Sequence conflicti285 – 2851F → N in CAA54453. (PubMed:8077208)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77236 mRNA. Translation: CAA54453.1.
    BC078747 mRNA. Translation: AAH78747.1.
    PIRiB55346.
    RefSeqiNP_598273.2. NM_133589.2.
    UniGeneiRn.9573.

    Genome annotation databases

    EnsembliENSRNOT00000021176; ENSRNOP00000021176; ENSRNOG00000015145.
    GeneIDi171121.
    KEGGirno:171121.
    UCSCiRGD:708460. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77236 mRNA. Translation: CAA54453.1 .
    BC078747 mRNA. Translation: AAH78747.1 .
    PIRi B55346.
    RefSeqi NP_598273.2. NM_133589.2.
    UniGenei Rn.9573.

    3D structure databases

    ProteinModelPortali Q64620.
    SMRi Q64620. Positions 5-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64620. 2 interactions.
    STRINGi 10116.ENSRNOP00000021176.

    PTM databases

    PhosphoSitei Q64620.

    Proteomic databases

    PRIDEi Q64620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021176 ; ENSRNOP00000021176 ; ENSRNOG00000015145 .
    GeneIDi 171121.
    KEGGi rno:171121.
    UCSCi RGD:708460. rat.

    Organism-specific databases

    CTDi 5537.
    RGDi 708460. Ppp6c.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00550000074961.
    HOGENOMi HOG000172696.
    HOVERGENi HBG000216.
    InParanoidi Q64620.
    KOi K15498.
    OMAi VPETSYI.
    OrthoDBi EOG74N5H2.
    PhylomeDBi Q64620.
    TreeFami TF105563.

    Miscellaneous databases

    NextBioi 621862.
    PROi Q64620.

    Gene expression databases

    Genevestigatori Q64620.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain."
      Becker W., Kentrup H., Klumpp S., Schultz J.E., Joost H.G.
      J. Biol. Chem. 269:22586-22592(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway.
      Tissue: Testis.

    Entry informationi

    Entry nameiPPP6_RAT
    AccessioniPrimary (citable) accession number: Q64620
    Secondary accession number(s): Q6AZ47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3