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Q64612

- PTPRV_RAT

UniProt

Q64612 - PTPRV_RAT

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Protein
Receptor-type tyrosine-protein phosphatase V
Gene
Ptprv, Esp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

pH dependencei

Optimum pH is 5.6.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1316 – 13161Substrate By similarity
Active sitei1350 – 13501Phosphocysteine intermediate By similarity
Binding sitei1394 – 13941Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. bone remodeling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
Short name:
R-PTP-V
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name:
ES cell phosphatase
Osteotesticular protein-tyrosine phosphatase
Short name:
OST-PTP
Gene namesi
Name:Ptprv
Synonyms:Esp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621123. Ptprv.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 10741057Extracellular Reviewed prediction
Add
BLAST
Transmembranei1075 – 109521Helical; Reviewed prediction
Add
BLAST
Topological domaini1096 – 1711616Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 17111694Receptor-type tyrosine-protein phosphatase V
PRO_0000025467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi620 – 6201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi649 – 6491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi663 – 6631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi737 – 7371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi851 – 8511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi882 – 8821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi970 – 9701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi982 – 9821N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The cytoplasmic domain contains potential phosphorylation sites.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64612.
PRIDEiQ64612.

Expressioni

Tissue specificityi

Bone and testis. In the latter, restricted to the basal portion of the seminiferous tubule.

Developmental stagei

Up-regulated in differentiating cultures of primary osteoblasts and down-regulated in late stage mineralizing cultures. In testis, expression is highest between stages I and VII when maturing spermatids remain buried within the Sertoli epithelium.

Inductioni

By parathyroid hormone and cAMP analogs.

Gene expression databases

GenevestigatoriQ64612.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007597.

Structurei

3D structure databases

ProteinModelPortaliQ64612.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12993Fibronectin type-III 1
Add
BLAST
Domaini130 – 22293Fibronectin type-III 2
Add
BLAST
Domaini218 – 30588Fibronectin type-III 3
Add
BLAST
Domaini306 – 39186Fibronectin type-III 4
Add
BLAST
Domaini393 – 47078Fibronectin type-III 5
Add
BLAST
Domaini475 – 56995Fibronectin type-III 6
Add
BLAST
Domaini565 – 65490Fibronectin type-III 7
Add
BLAST
Domaini655 – 74995Fibronectin type-III 8
Add
BLAST
Domaini744 – 83188Fibronectin type-III 9
Add
BLAST
Domaini832 – 92695Fibronectin type-III 10
Add
BLAST
Domaini1150 – 1409260Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1427 – 1696270Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1350 – 13567Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000168222.
HOVERGENiHBG053764.
InParanoidiQ64612.
KOiK18036.
PhylomeDBiQ64612.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: A presumed alternate transcript of 4.8-5.0 kilobases, which may lack PTP domains, is present in proliferating osteoblasts, but not detectable at other stages.

Isoform 1 (identifier: Q64612-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRPLILLAAL LWLQGFLAED DACSSLEGSP DRQGGGPLLS VNVSSHGKST     50
SLFLSWVAAE LGGFDYALSL RSVNSSGSPE GQQLQAHTNE SGFEFHGLVP 100
GSRYQLKLTV LRPCWQNVTI TLTARTAPTV VRGLQLHSAG SPARLEASWS 150
DAPGDQDSYQ LLLYHLESQT LACNVSVSPD TLSYSFGDLL PGTQYVLEVI 200
TWAGSLHAKT SILQWTEPVP PDHLALRALG TSSLQAFWNS SEGATSFHLM 250
LTDLLGGTNT TAVIRQGVST HTFLHLSPGT PHELKICASA GPHQIWGPSA 300
TEWTYPSYPS DLVLTPLRNE LWASWKAGLG ARDGYVLKLS GPMESTSTLG 350
PEECNAVFPG PLPPGHYTLQ LKVLAGPYDA WVEGSTWLAE SAALPREVPG 400
ARLWLDGLEA SKQPGRRALL YSDDAPGSLG NISVPSGATH VIFCGLVPGA 450
HYRVDIASST GDISQSISGY TSPLPPQSLE VISRSSPSDL TIAWGPAPGQ 500
LEGYKVTWHQ DGSQRSPGDL VDLGPDTLSL TLKSLVPGSC YTVSAWAWAG 550
NLDSDSQKIH SCTRPAPPTN LSLGFAHQPA ALKASWYHPP GGRDAFHLRL 600
YRLRPLTLES EKVLPREAQN FSWAQLTAGC EFQVQLSTLW GSERSSSANA 650
TGWTPPSAPT LVNVTSDAPT QLQVSWAHVP GGRSRYQVTL YQESTRTATS 700
IMGPKEDGTS FLGLTPGTKY KVEVISWAGP LYTAAANVSA WTYPLIPNEL 750
LVSMQAGSAV VNLAWPSGPL GQGACHAQLS DAGHLSWEQP LKLGQELFML 800
RDLTPGHTIS MSVRCRAGPL QASTHLVVLS VEPGPVEDVL CHPEATYLAL 850
NWTMPAGDVD VCLVVVERLV PGGGTHFVFQ VNTSGDALLL PNLMPTTSYR 900
LSLTVLGRNS RWSRAVSLVC STSAEAWHPP ELAEPPQVEL GTGMGVTVMR 950
GMFGKDDGQI QWYGIIATIN MTLAQPSREA INYTWYDHYY RGCESFLALL 1000
FPNPFYPEPW AGPRSWTVPV GTEDCDNTQE ICNGRLKSGF QYRFSVVAFS 1050
RLNTPETILA FSAFSEPRAS ISLAIIPLTV MLGAVVGSIV IVCAVLCLLR 1100
WRCLKGPRSE KDGFSKELMP YNLWRTHRPI PIHSFRQSYE AKSAHAHQTF 1150
FQEFEELKEV GKDQPRLEAE HPDNIIKNRY PHVLPYDHSR VRLTQLPGEP 1200
HSDYINANFI PGYSHTQEII ATQGPLKKTL EDFWRLVWEQ QVHVIIMLTV 1250
GMENGRVLCE HYWPANSTPV THGHITIHLL AEEPEDEWTR REFQLQHGTE 1300
QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEQVQAT QGKGPILVHC 1350
SAGVGRTGTF VALLRLLRQL EEEKVADVFN TVYILRLHRP LMIQTLSQYI 1400
FLHSCLLNKI LEGPPDSSDS GPISVMDFAQ ACAKRAANAN AGFLKEYKLL 1450
KQAIKDGTGS LLPPPDYNQN SIVSRRHSQE QFALVEECPE DSMLEASLFP 1500
GGPSGCDHVV LTGSAGPKEL WEMVWEHDAH VLVSLGLPDT KEKPPDIWPV 1550
EMQPIVTDMV TVHRVSESNT TTGWPSTLFR VIHGESGKER QVQCLQFPCS 1600
ESGCELPANT LLTFLDAVGQ CCFRGKSKKP GTLLSHSSKN TNQLGTFLAM 1650
EQLLQQAGTE RTVDVFNVAL KQSQACGLMT PTLEQYIYLY NCLNSALLNG 1700
LPRAGKWPAP C 1711
Length:1,711
Mass (Da):187,293
Last modified:November 1, 1996 - v1
Checksum:i0F04D2D1A47A18A0
GO
Isoform 2 (identifier: Q64612-2)

Sequence is not available

Note: No experimental confirmation available.

Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36884 mRNA. Translation: AAA63911.1.
PIRiA55148.
RefSeqiNP_149090.1. NM_033099.1. [Q64612-1]
UniGeneiRn.10048.

Genome annotation databases

GeneIDi64576.
KEGGirno:64576.
UCSCiRGD:621123. rat. [Q64612-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36884 mRNA. Translation: AAA63911.1 .
PIRi A55148.
RefSeqi NP_149090.1. NM_033099.1. [Q64612-1 ]
UniGenei Rn.10048.

3D structure databases

ProteinModelPortali Q64612.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007597.

Proteomic databases

PaxDbi Q64612.
PRIDEi Q64612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64576.
KEGGi rno:64576.
UCSCi RGD:621123. rat. [Q64612-1 ]

Organism-specific databases

CTDi 13924.
RGDi 621123. Ptprv.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000168222.
HOVERGENi HBG053764.
InParanoidi Q64612.
KOi K18036.
PhylomeDBi Q64612.

Miscellaneous databases

NextBioi 613540.

Gene expression databases

Genevestigatori Q64612.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation."
    Mauro L.J., Olmsted E.A., Skrobacz B.M., Mourey R.J., Davis A.R., Dixon J.E.
    J. Biol. Chem. 269:30659-30667(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.

Entry informationi

Entry nameiPTPRV_RAT
AccessioniPrimary (citable) accession number: Q64612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi