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Protein

Receptor-type tyrosine-protein phosphatase V

Gene

Ptprv

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

pH dependencei

Optimum pH is 5.6.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1316 – 13161SubstrateBy similarity
Active sitei1350 – 13501Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1394 – 13941SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

  • bone remodeling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
Short name:
R-PTP-V
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name:
ES cell phosphatase
Osteotesticular protein-tyrosine phosphatase
Short name:
OST-PTP
Gene namesi
Name:Ptprv
Synonyms:Esp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621123. Ptprv.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 10741057ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1075 – 109521HelicalSequence AnalysisAdd
BLAST
Topological domaini1096 – 1711616CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 17111694Receptor-type tyrosine-protein phosphatase VPRO_0000025467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi663 – 6631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi970 – 9701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The cytoplasmic domain contains potential phosphorylation sites.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64612.
PRIDEiQ64612.

Expressioni

Tissue specificityi

Bone and testis. In the latter, restricted to the basal portion of the seminiferous tubule.

Developmental stagei

Up-regulated in differentiating cultures of primary osteoblasts and down-regulated in late stage mineralizing cultures. In testis, expression is highest between stages I and VII when maturing spermatids remain buried within the Sertoli epithelium.

Inductioni

By parathyroid hormone and cAMP analogs.

Gene expression databases

GenevestigatoriQ64612.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007597.

Structurei

3D structure databases

ProteinModelPortaliQ64612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12993Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 22293Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini218 – 30588Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 39186Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 47078Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini475 – 56995Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini565 – 65490Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini655 – 74995Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini744 – 83188Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 92695Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1150 – 1409260Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1427 – 1696270Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1350 – 13567Substrate bindingBy similarity

Sequence similaritiesi

Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000168222.
HOVERGENiHBG053764.
InParanoidiQ64612.
KOiK18036.
PhylomeDBiQ64612.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A presumed alternate transcript of 4.8-5.0 kilobases, which may lack PTP domains, is present in proliferating osteoblasts, but not detectable at other stages.

Isoform 1 (identifier: Q64612-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLILLAAL LWLQGFLAED DACSSLEGSP DRQGGGPLLS VNVSSHGKST
60 70 80 90 100
SLFLSWVAAE LGGFDYALSL RSVNSSGSPE GQQLQAHTNE SGFEFHGLVP
110 120 130 140 150
GSRYQLKLTV LRPCWQNVTI TLTARTAPTV VRGLQLHSAG SPARLEASWS
160 170 180 190 200
DAPGDQDSYQ LLLYHLESQT LACNVSVSPD TLSYSFGDLL PGTQYVLEVI
210 220 230 240 250
TWAGSLHAKT SILQWTEPVP PDHLALRALG TSSLQAFWNS SEGATSFHLM
260 270 280 290 300
LTDLLGGTNT TAVIRQGVST HTFLHLSPGT PHELKICASA GPHQIWGPSA
310 320 330 340 350
TEWTYPSYPS DLVLTPLRNE LWASWKAGLG ARDGYVLKLS GPMESTSTLG
360 370 380 390 400
PEECNAVFPG PLPPGHYTLQ LKVLAGPYDA WVEGSTWLAE SAALPREVPG
410 420 430 440 450
ARLWLDGLEA SKQPGRRALL YSDDAPGSLG NISVPSGATH VIFCGLVPGA
460 470 480 490 500
HYRVDIASST GDISQSISGY TSPLPPQSLE VISRSSPSDL TIAWGPAPGQ
510 520 530 540 550
LEGYKVTWHQ DGSQRSPGDL VDLGPDTLSL TLKSLVPGSC YTVSAWAWAG
560 570 580 590 600
NLDSDSQKIH SCTRPAPPTN LSLGFAHQPA ALKASWYHPP GGRDAFHLRL
610 620 630 640 650
YRLRPLTLES EKVLPREAQN FSWAQLTAGC EFQVQLSTLW GSERSSSANA
660 670 680 690 700
TGWTPPSAPT LVNVTSDAPT QLQVSWAHVP GGRSRYQVTL YQESTRTATS
710 720 730 740 750
IMGPKEDGTS FLGLTPGTKY KVEVISWAGP LYTAAANVSA WTYPLIPNEL
760 770 780 790 800
LVSMQAGSAV VNLAWPSGPL GQGACHAQLS DAGHLSWEQP LKLGQELFML
810 820 830 840 850
RDLTPGHTIS MSVRCRAGPL QASTHLVVLS VEPGPVEDVL CHPEATYLAL
860 870 880 890 900
NWTMPAGDVD VCLVVVERLV PGGGTHFVFQ VNTSGDALLL PNLMPTTSYR
910 920 930 940 950
LSLTVLGRNS RWSRAVSLVC STSAEAWHPP ELAEPPQVEL GTGMGVTVMR
960 970 980 990 1000
GMFGKDDGQI QWYGIIATIN MTLAQPSREA INYTWYDHYY RGCESFLALL
1010 1020 1030 1040 1050
FPNPFYPEPW AGPRSWTVPV GTEDCDNTQE ICNGRLKSGF QYRFSVVAFS
1060 1070 1080 1090 1100
RLNTPETILA FSAFSEPRAS ISLAIIPLTV MLGAVVGSIV IVCAVLCLLR
1110 1120 1130 1140 1150
WRCLKGPRSE KDGFSKELMP YNLWRTHRPI PIHSFRQSYE AKSAHAHQTF
1160 1170 1180 1190 1200
FQEFEELKEV GKDQPRLEAE HPDNIIKNRY PHVLPYDHSR VRLTQLPGEP
1210 1220 1230 1240 1250
HSDYINANFI PGYSHTQEII ATQGPLKKTL EDFWRLVWEQ QVHVIIMLTV
1260 1270 1280 1290 1300
GMENGRVLCE HYWPANSTPV THGHITIHLL AEEPEDEWTR REFQLQHGTE
1310 1320 1330 1340 1350
QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEQVQAT QGKGPILVHC
1360 1370 1380 1390 1400
SAGVGRTGTF VALLRLLRQL EEEKVADVFN TVYILRLHRP LMIQTLSQYI
1410 1420 1430 1440 1450
FLHSCLLNKI LEGPPDSSDS GPISVMDFAQ ACAKRAANAN AGFLKEYKLL
1460 1470 1480 1490 1500
KQAIKDGTGS LLPPPDYNQN SIVSRRHSQE QFALVEECPE DSMLEASLFP
1510 1520 1530 1540 1550
GGPSGCDHVV LTGSAGPKEL WEMVWEHDAH VLVSLGLPDT KEKPPDIWPV
1560 1570 1580 1590 1600
EMQPIVTDMV TVHRVSESNT TTGWPSTLFR VIHGESGKER QVQCLQFPCS
1610 1620 1630 1640 1650
ESGCELPANT LLTFLDAVGQ CCFRGKSKKP GTLLSHSSKN TNQLGTFLAM
1660 1670 1680 1690 1700
EQLLQQAGTE RTVDVFNVAL KQSQACGLMT PTLEQYIYLY NCLNSALLNG
1710
LPRAGKWPAP C
Length:1,711
Mass (Da):187,293
Last modified:November 1, 1996 - v1
Checksum:i0F04D2D1A47A18A0
GO
Isoform 2 (identifier: Q64612-2)

Sequence is not available

Note: No experimental confirmation available.

Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36884 mRNA. Translation: AAA63911.1.
PIRiA55148.
RefSeqiNP_149090.1. NM_033099.1. [Q64612-1]
UniGeneiRn.10048.

Genome annotation databases

GeneIDi64576.
KEGGirno:64576.
UCSCiRGD:621123. rat. [Q64612-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36884 mRNA. Translation: AAA63911.1.
PIRiA55148.
RefSeqiNP_149090.1. NM_033099.1. [Q64612-1]
UniGeneiRn.10048.

3D structure databases

ProteinModelPortaliQ64612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007597.

Proteomic databases

PaxDbiQ64612.
PRIDEiQ64612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64576.
KEGGirno:64576.
UCSCiRGD:621123. rat. [Q64612-1]

Organism-specific databases

CTDi13924.
RGDi621123. Ptprv.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000168222.
HOVERGENiHBG053764.
InParanoidiQ64612.
KOiK18036.
PhylomeDBiQ64612.

Miscellaneous databases

NextBioi613540.
PROiQ64612.

Gene expression databases

GenevestigatoriQ64612.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation."
    Mauro L.J., Olmsted E.A., Skrobacz B.M., Mourey R.J., Davis A.R., Dixon J.E.
    J. Biol. Chem. 269:30659-30667(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.

Entry informationi

Entry nameiPTPRV_RAT
AccessioniPrimary (citable) accession number: Q64612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.