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Q64612

- PTPRV_RAT

UniProt

Q64612 - PTPRV_RAT

Protein

Receptor-type tyrosine-protein phosphatase V

Gene

Ptprv

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    pH dependencei

    Optimum pH is 5.6.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1316 – 13161SubstrateBy similarity
    Active sitei1350 – 13501Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1394 – 13941SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. bone remodeling Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
    Short name:
    R-PTP-V
    Alternative name(s):
    Embryonic stem cell protein-tyrosine phosphatase
    Short name:
    ES cell phosphatase
    Osteotesticular protein-tyrosine phosphatase
    Short name:
    OST-PTP
    Gene namesi
    Name:Ptprv
    Synonyms:Esp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621123. Ptprv.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 17111694Receptor-type tyrosine-protein phosphatase VPRO_0000025467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi663 – 6631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi970 – 9701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The cytoplasmic domain contains potential phosphorylation sites.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ64612.
    PRIDEiQ64612.

    Expressioni

    Tissue specificityi

    Bone and testis. In the latter, restricted to the basal portion of the seminiferous tubule.

    Developmental stagei

    Up-regulated in differentiating cultures of primary osteoblasts and down-regulated in late stage mineralizing cultures. In testis, expression is highest between stages I and VII when maturing spermatids remain buried within the Sertoli epithelium.

    Inductioni

    By parathyroid hormone and cAMP analogs.

    Gene expression databases

    GenevestigatoriQ64612.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007597.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64612.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 10741057ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1096 – 1711616CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1075 – 109521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 12993Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 22293Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 30588Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 39186Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 47078Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini475 – 56995Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini565 – 65490Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 74995Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini744 – 83188Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini832 – 92695Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1150 – 1409260Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1427 – 1696270Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1350 – 13567Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000168222.
    HOVERGENiHBG053764.
    InParanoidiQ64612.
    KOiK18036.
    PhylomeDBiQ64612.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 8 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: A presumed alternate transcript of 4.8-5.0 kilobases, which may lack PTP domains, is present in proliferating osteoblasts, but not detectable at other stages.

    Isoform 1 (identifier: Q64612-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MRPLILLAAL LWLQGFLAED DACSSLEGSP DRQGGGPLLS VNVSSHGKST     50
    SLFLSWVAAE LGGFDYALSL RSVNSSGSPE GQQLQAHTNE SGFEFHGLVP 100
    GSRYQLKLTV LRPCWQNVTI TLTARTAPTV VRGLQLHSAG SPARLEASWS 150
    DAPGDQDSYQ LLLYHLESQT LACNVSVSPD TLSYSFGDLL PGTQYVLEVI 200
    TWAGSLHAKT SILQWTEPVP PDHLALRALG TSSLQAFWNS SEGATSFHLM 250
    LTDLLGGTNT TAVIRQGVST HTFLHLSPGT PHELKICASA GPHQIWGPSA 300
    TEWTYPSYPS DLVLTPLRNE LWASWKAGLG ARDGYVLKLS GPMESTSTLG 350
    PEECNAVFPG PLPPGHYTLQ LKVLAGPYDA WVEGSTWLAE SAALPREVPG 400
    ARLWLDGLEA SKQPGRRALL YSDDAPGSLG NISVPSGATH VIFCGLVPGA 450
    HYRVDIASST GDISQSISGY TSPLPPQSLE VISRSSPSDL TIAWGPAPGQ 500
    LEGYKVTWHQ DGSQRSPGDL VDLGPDTLSL TLKSLVPGSC YTVSAWAWAG 550
    NLDSDSQKIH SCTRPAPPTN LSLGFAHQPA ALKASWYHPP GGRDAFHLRL 600
    YRLRPLTLES EKVLPREAQN FSWAQLTAGC EFQVQLSTLW GSERSSSANA 650
    TGWTPPSAPT LVNVTSDAPT QLQVSWAHVP GGRSRYQVTL YQESTRTATS 700
    IMGPKEDGTS FLGLTPGTKY KVEVISWAGP LYTAAANVSA WTYPLIPNEL 750
    LVSMQAGSAV VNLAWPSGPL GQGACHAQLS DAGHLSWEQP LKLGQELFML 800
    RDLTPGHTIS MSVRCRAGPL QASTHLVVLS VEPGPVEDVL CHPEATYLAL 850
    NWTMPAGDVD VCLVVVERLV PGGGTHFVFQ VNTSGDALLL PNLMPTTSYR 900
    LSLTVLGRNS RWSRAVSLVC STSAEAWHPP ELAEPPQVEL GTGMGVTVMR 950
    GMFGKDDGQI QWYGIIATIN MTLAQPSREA INYTWYDHYY RGCESFLALL 1000
    FPNPFYPEPW AGPRSWTVPV GTEDCDNTQE ICNGRLKSGF QYRFSVVAFS 1050
    RLNTPETILA FSAFSEPRAS ISLAIIPLTV MLGAVVGSIV IVCAVLCLLR 1100
    WRCLKGPRSE KDGFSKELMP YNLWRTHRPI PIHSFRQSYE AKSAHAHQTF 1150
    FQEFEELKEV GKDQPRLEAE HPDNIIKNRY PHVLPYDHSR VRLTQLPGEP 1200
    HSDYINANFI PGYSHTQEII ATQGPLKKTL EDFWRLVWEQ QVHVIIMLTV 1250
    GMENGRVLCE HYWPANSTPV THGHITIHLL AEEPEDEWTR REFQLQHGTE 1300
    QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEQVQAT QGKGPILVHC 1350
    SAGVGRTGTF VALLRLLRQL EEEKVADVFN TVYILRLHRP LMIQTLSQYI 1400
    FLHSCLLNKI LEGPPDSSDS GPISVMDFAQ ACAKRAANAN AGFLKEYKLL 1450
    KQAIKDGTGS LLPPPDYNQN SIVSRRHSQE QFALVEECPE DSMLEASLFP 1500
    GGPSGCDHVV LTGSAGPKEL WEMVWEHDAH VLVSLGLPDT KEKPPDIWPV 1550
    EMQPIVTDMV TVHRVSESNT TTGWPSTLFR VIHGESGKER QVQCLQFPCS 1600
    ESGCELPANT LLTFLDAVGQ CCFRGKSKKP GTLLSHSSKN TNQLGTFLAM 1650
    EQLLQQAGTE RTVDVFNVAL KQSQACGLMT PTLEQYIYLY NCLNSALLNG 1700
    LPRAGKWPAP C 1711
    Length:1,711
    Mass (Da):187,293
    Last modified:November 1, 1996 - v1
    Checksum:i0F04D2D1A47A18A0
    GO
    Isoform 2 (identifier: Q64612-2)

    Sequence is not available

    Note: No experimental confirmation available.

    Length:
    Mass (Da):

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36884 mRNA. Translation: AAA63911.1.
    PIRiA55148.
    RefSeqiNP_149090.1. NM_033099.1. [Q64612-1]
    UniGeneiRn.10048.

    Genome annotation databases

    GeneIDi64576.
    KEGGirno:64576.
    UCSCiRGD:621123. rat. [Q64612-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36884 mRNA. Translation: AAA63911.1 .
    PIRi A55148.
    RefSeqi NP_149090.1. NM_033099.1. [Q64612-1 ]
    UniGenei Rn.10048.

    3D structure databases

    ProteinModelPortali Q64612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007597.

    Proteomic databases

    PaxDbi Q64612.
    PRIDEi Q64612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64576.
    KEGGi rno:64576.
    UCSCi RGD:621123. rat. [Q64612-1 ]

    Organism-specific databases

    CTDi 13924.
    RGDi 621123. Ptprv.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000168222.
    HOVERGENi HBG053764.
    InParanoidi Q64612.
    KOi K18036.
    PhylomeDBi Q64612.

    Miscellaneous databases

    NextBioi 613540.

    Gene expression databases

    Genevestigatori Q64612.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 8 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation."
      Mauro L.J., Olmsted E.A., Skrobacz B.M., Mourey R.J., Davis A.R., Dixon J.E.
      J. Biol. Chem. 269:30659-30667(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Osteosarcoma.

    Entry informationi

    Entry nameiPTPRV_RAT
    AccessioniPrimary (citable) accession number: Q64612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3