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Protein

Cysteine sulfinic acid decarboxylase

Gene

Csad

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-sulfino-L-alanine = hypotaurine + CO2.

Cofactori

Pathwayi: taurine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes hypotaurine from L-cysteine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cysteine dioxygenase type 1 (Cdo1)
  2. Cysteine sulfinic acid decarboxylase (Csad)
This subpathway is part of the pathway taurine biosynthesis, which is itself part of Organosulfur biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes hypotaurine from L-cysteine, the pathway taurine biosynthesis and in Organosulfur biosynthesis.

GO - Molecular functioni

  • pyridoxal phosphate binding Source: InterPro
  • sulfinoalanine decarboxylase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13316.
ReactomeiR-RNO-1614558. Degradation of cysteine and homocysteine.
UniPathwayiUPA00012; UER00538.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine sulfinic acid decarboxylase (EC:4.1.1.29)
Alternative name(s):
Cysteine-sulfinate decarboxylase
Sulfinoalanine decarboxylase
Gene namesi
Name:Csad
Synonyms:Csd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621030. Csad.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470081 – 493Cysteine sulfinic acid decarboxylaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ64611.
PRIDEiQ64611.

PTM databases

iPTMnetiQ64611.
PhosphoSitePlusiQ64611.

Expressioni

Tissue specificityi

Expressed in brain, liver and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000011573.
ExpressionAtlasiQ64611. baseline and differential.
GenevisibleiQ64611. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016205.

Structurei

3D structure databases

ProteinModelPortaliQ64611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ64611.
KOiK01594.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ64611.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKPLRTL DGDPVAVEAL LRDVFGIVVD EAIRKGTNAS EKVCEWKEPE
60 70 80 90 100
ELKQLLDLEL QSQGESRERI LERCRAVIHY SVKTGHPRFF NQLFSGLDPH
110 120 130 140 150
ALAGRIITES LNTSQYTYEI APVFVLMEEE VLKKLRALVG WNTGDGVFCP
160 170 180 190 200
GGSISNMYAI NLARFQRYPD CKQRGLRALP PLALFTSKEC HYSITKGAAF
210 220 230 240 250
LGLGTDSVRV VKADERGKMI PEDLERQISL AEAEGSVPFL VSATSGTTVL
260 270 280 290 300
GAFDPLDAIA DVCQRHGLWL HVDAAWGGSV LLSRTHRHLL DGIQRADSVA
310 320 330 340 350
WNPHKLLAAG LQCSALLLRD TSNLLKRCHG SQASYLFQQD KFYNVALDTG
360 370 380 390 400
DKVVQCGRRV DCLKLWLMWK AQGGQGLEWR IDQAFALTRY LVEEIKKREG
410 420 430 440 450
FELVMEPEFV NVCFWFVPPS LRGKKESPDY SQRLSQVAPV LKERMVKKGT
460 470 480 490
MMIGYQPHGT RANFFRMVVA NPILVQADID FLLGELERLG QDL
Length:493
Mass (Da):55,249
Last modified:November 1, 1996 - v1
Checksum:i31B7AA2F48CEC58C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178A → V in AAC42063 (PubMed:7772604).Curated1
Sequence conflicti458 – 493HGTRA…LGQDL → MGPGPTSSEWWWPTPYWSRP I in AAC42063 (PubMed:7772604).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64755 mRNA. Translation: AAC42063.1.
X94152 mRNA. Translation: CAA63868.1.
AJ132661 mRNA. Translation: CAB54561.1.
BC081804 mRNA. Translation: AAH81804.1.
AF115343 Genomic DNA. Translation: AAD47908.1.
PIRiS71489.
RefSeqiNP_068518.1. NM_021750.2.
XP_006242500.1. XM_006242438.3.
XP_006242501.1. XM_006242439.2.
XP_006242502.1. XM_006242440.3.
XP_006242504.1. XM_006242442.3.
XP_008764004.1. XM_008765782.2.
XP_017450565.1. XM_017595076.1.
UniGeneiRn.43232.

Genome annotation databases

EnsembliENSRNOT00000016205; ENSRNOP00000016205; ENSRNOG00000011573.
GeneIDi60356.
KEGGirno:60356.
UCSCiRGD:621030. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64755 mRNA. Translation: AAC42063.1.
X94152 mRNA. Translation: CAA63868.1.
AJ132661 mRNA. Translation: CAB54561.1.
BC081804 mRNA. Translation: AAH81804.1.
AF115343 Genomic DNA. Translation: AAD47908.1.
PIRiS71489.
RefSeqiNP_068518.1. NM_021750.2.
XP_006242500.1. XM_006242438.3.
XP_006242501.1. XM_006242439.2.
XP_006242502.1. XM_006242440.3.
XP_006242504.1. XM_006242442.3.
XP_008764004.1. XM_008765782.2.
XP_017450565.1. XM_017595076.1.
UniGeneiRn.43232.

3D structure databases

ProteinModelPortaliQ64611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016205.

PTM databases

iPTMnetiQ64611.
PhosphoSitePlusiQ64611.

Proteomic databases

PaxDbiQ64611.
PRIDEiQ64611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016205; ENSRNOP00000016205; ENSRNOG00000011573.
GeneIDi60356.
KEGGirno:60356.
UCSCiRGD:621030. rat.

Organism-specific databases

CTDi51380.
RGDi621030. Csad.

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ64611.
KOiK01594.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ64611.
TreeFamiTF314688.

Enzyme and pathway databases

UniPathwayiUPA00012; UER00538.
BioCyciMetaCyc:MONOMER-13316.
ReactomeiR-RNO-1614558. Degradation of cysteine and homocysteine.

Miscellaneous databases

PROiQ64611.

Gene expression databases

BgeeiENSRNOG00000011573.
ExpressionAtlasiQ64611. baseline and differential.
GenevisibleiQ64611. RN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSAD_RAT
AccessioniPrimary (citable) accession number: Q64611
Secondary accession number(s): Q546T1, Q64577, Q9R1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.