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Q64604

- PTPRF_RAT

UniProt

Q64604 - PTPRF_RAT

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Protein
Receptor-type tyrosine-protein phosphatase F
Gene
Ptprf, Lar
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.1 Publication
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one By similarity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1507 – 15071Substrate By similarity
Active sitei1539 – 15391Phosphocysteine intermediate By similarity
Binding sitei1583 – 15831Substrate By similarity
Active sitei1830 – 18301Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. insulin receptor binding Source: RGD
  3. phosphate ion binding Source: RGD
  4. protein tyrosine phosphatase activity Source: UniProtKB
  5. receptor tyrosine kinase binding Source: RGD
  6. transmembrane receptor protein tyrosine phosphatase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. homophilic cell adhesion Source: RGD
  3. negative regulation of cell projection organization Source: RGD
  4. negative regulation of cell proliferation Source: RGD
  5. negative regulation of cytokine-mediated signaling pathway Source: RGD
  6. negative regulation of epidermal growth factor receptor signaling pathway Source: RGD
  7. negative regulation of insulin receptor signaling pathway Source: RGD
  8. negative regulation of neurotrophin TRK receptor signaling pathway Source: RGD
  9. negative regulation of receptor binding Source: UniProtKB
  10. nervous system development Source: RGD
  11. peptidyl-tyrosine dephosphorylation Source: GOC
  12. positive regulation of apoptotic process Source: RGD
  13. positive regulation of dendrite morphogenesis Source: RGD
  14. positive regulation of neuron apoptotic process Source: RGD
  15. protein dephosphorylation Source: RGD
  16. regulation of synapse structure and activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen related
Short name:
LAR
Gene namesi
Name:Ptprf
Synonyms:Lar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3453. Ptprf.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12541225Extracellular Reviewed prediction
Add
BLAST
Transmembranei1255 – 127521Helical; Reviewed prediction
Add
BLAST
Topological domaini1276 – 1898623Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome Source: RGD
  2. excitatory synapse Source: RGD
  3. growth cone Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular membrane-bounded organelle Source: RGD
  6. membrane Source: RGD
  7. neuron projection Source: RGD
  8. neuronal cell body Source: RGD
  9. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 18981869Receptor-type tyrosine-protein phosphatase F
PRO_5000142152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107 By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi156 ↔ 207 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi253 ↔ 298 By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi941 – 9411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64604.
PRIDEiQ64604.

Expressioni

Gene expression databases

GenevestigatoriQ64604.

Interactioni

Subunit structurei

Interacts with GRIP1 By similarity. Interacts with PPFIA1, PPFIA2 and PPFIA3 By similarity. Interacts with PTPRF By similarity.

Protein-protein interaction databases

IntActiQ64604. 4 interactions.
STRINGi10116.ENSRNOP00000027271.

Structurei

3D structure databases

ProteinModelPortaliQ64604.
SMRiQ64604. Positions 319-415, 596-719, 814-904, 909-1001, 1325-1893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1
Add
BLAST
Domaini135 – 22490Ig-like C2-type 2
Add
BLAST
Domaini232 – 31483Ig-like C2-type 3
Add
BLAST
Domaini321 – 41191Fibronectin type-III 1
Add
BLAST
Domaini416 – 51095Fibronectin type-III 2
Add
BLAST
Domaini514 – 60491Fibronectin type-III 3
Add
BLAST
Domaini609 – 70698Fibronectin type-III 4
Add
BLAST
Domaini711 – 810100Fibronectin type-III 5
Add
BLAST
Domaini811 – 90595Fibronectin type-III 6
Add
BLAST
Domaini909 – 100193Fibronectin type-III 7
Add
BLAST
Domaini1005 – 108985Fibronectin type-III 8
Add
BLAST
Domaini1343 – 1598256Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1630 – 1889260Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 7710Heparin-binding By similarity
Regioni1539 – 15457Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000010250.
InParanoidiQ64604.
KOiK05695.
PhylomeDBiQ64604.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64604-1 [UniParc]FASTAAdd to Basket

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MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQIGLSGGVA     50
SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR 100
DEAIYECTAT NSLGEINTSA KLSVLEEDQL PSGFPTIDMG PQLKVVEKAR 150
TATMLCAAGG NPDPEISWFK DFLPVDPASS NGRIKQLRSG ALQIESSEES 200
DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGNVN 250
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA 300
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY 350
GIQYRAAGTD GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP 400
SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY 450
YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS 500
PTIQVKTQQG VPAQPADFQA KAESDTRIQL SWLLPPQERI IKYELVYWAA 550
EDEGQQHKVT FDPTSSYTLE DLKPDTLYHF QLAARSDLGV GVFTPTVEAC 600
TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD 650
GEDRKRHVVD GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL 700
VRTDEDVPSG PPRKVEVEPL NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR 750
LENGEPRGQP IIQDVMLAEA QETTISGLTP ETTYSITVAA YTTKGDGARS 800
KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE LLGYRLQYRR 850
ADEARPNTID FGKDDQHFTV TGLHKGATYI FRLAAKNRAG PGEEFEKEIT 900
TPEDAPSGFP QNLRVTGLTT STTELAWDPP VLAERNGRIT NYTVVYRDIN 950
SQHELQNVTG DVHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP 1000
MEQVFAKNFR VAAAMKTSVL LSWEVPDSYK SAVPFKILYN GQSVEVDGHS 1050
MRKLIADLQP NTEYSFVLMN RGTSAGGLQH LVSIRTAPDL LPQKPLPASA 1100
FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP RWSTPEELEL 1150
DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDELPETFT LGDKKNYRGF 1200
YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP 1250
EMLWVTGPVL AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH 1300
SSDPVEMRRL NYQTPGMRDH PPIPITDLAD NIERLKANDG LKFSQEYESI 1350
DPGQQFTWEN SNSEVNKPKN RYANVIAYDH SRVLLTSIDG VPGSDYINAN 1400
YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRIATVVMM TRLEEKSRVK 1450
CDQYWPARGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF 1500
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI 1550
VIDAMLERMK HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM 1600
CGHTEVLARN LYAHIQKLGQ VPPGESVTAM ELEFKLLAGS KARASRFISA 1650
NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF LDGYRQQKAY 1700
IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC HQYWPAERSA 1750
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM 1850
RYEGVVDMFQ TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898
Length:1,898
Mass (Da):211,494
Last modified:November 1, 1996 - v1
Checksum:iDF4D7E46F5896F4B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1073 – 10731T → S in AAA41510. 1 Publication
Sequence conflicti1434 – 14341I → T in AAA41510. 1 Publication
Sequence conflicti1639 – 16391G → N in AAA41510. 1 Publication
Sequence conflicti1643 – 16442RA → HT in AAA41510. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11586 mRNA. Translation: AAC37655.1.
M60103 mRNA. Translation: AAA41510.1.
PIRiS46216.
RefSeqiNP_062122.1. NM_019249.1.
UniGeneiRn.11386.

Genome annotation databases

GeneIDi360406.
KEGGirno:360406.
UCSCiRGD:3453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11586 mRNA. Translation: AAC37655.1 .
M60103 mRNA. Translation: AAA41510.1 .
PIRi S46216.
RefSeqi NP_062122.1. NM_019249.1.
UniGenei Rn.11386.

3D structure databases

ProteinModelPortali Q64604.
SMRi Q64604. Positions 319-415, 596-719, 814-904, 909-1001, 1325-1893.
ModBasei Search...

Protein-protein interaction databases

IntActi Q64604. 4 interactions.
STRINGi 10116.ENSRNOP00000027271.

Chemistry

BindingDBi Q64604.
ChEMBLi CHEMBL2834.

Proteomic databases

PaxDbi Q64604.
PRIDEi Q64604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360406.
KEGGi rno:360406.
UCSCi RGD:3453. rat.

Organism-specific databases

CTDi 5792.
RGDi 3453. Ptprf.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000010250.
InParanoidi Q64604.
KOi K05695.
PhylomeDBi Q64604.

Miscellaneous databases

NextBioi 672799.

Gene expression databases

Genevestigatori Q64604.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a unique receptor-like protein-tyrosine-phosphatase in the leucocyte-common-antigen-related phosphate family."
    Zhang W.-R., Hashimoto N., Ahmad F., Ding W., Goldstein B.J.
    Biochem. J. 302:39-47(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase."
    Pot D.A., Woodford T.A., Remboutsika E., Haun R.S., Dixon J.E.
    J. Biol. Chem. 266:19688-19696(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1035-1898, FUNCTION.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPTPRF_RAT
AccessioniPrimary (citable) accession number: Q64604
Secondary accession number(s): Q4JFJ1
, Q63294, Q63295, Q63296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi