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Q64604

- PTPRF_RAT

UniProt

Q64604 - PTPRF_RAT

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Protein

Receptor-type tyrosine-protein phosphatase F

Gene

Ptprf

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.1 Publication
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1507 – 15071SubstrateBy similarity
Active sitei1539 – 15391Phosphocysteine intermediateBy similarity
Binding sitei1583 – 15831SubstrateBy similarity
Active sitei1830 – 18301Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. insulin receptor binding Source: RGD
  3. phosphate ion binding Source: RGD
  4. protein tyrosine phosphatase activity Source: UniProtKB
  5. receptor tyrosine kinase binding Source: RGD
  6. transmembrane receptor protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. homophilic cell adhesion Source: RGD
  3. negative regulation of cell projection organization Source: RGD
  4. negative regulation of cell proliferation Source: RGD
  5. negative regulation of cytokine-mediated signaling pathway Source: RGD
  6. negative regulation of epidermal growth factor receptor signaling pathway Source: RGD
  7. negative regulation of insulin receptor signaling pathway Source: RGD
  8. negative regulation of neurotrophin TRK receptor signaling pathway Source: RGD
  9. negative regulation of receptor binding Source: UniProtKB
  10. nervous system development Source: RGD
  11. peptidyl-tyrosine dephosphorylation Source: GOC
  12. positive regulation of apoptotic process Source: RGD
  13. positive regulation of dendrite morphogenesis Source: RGD
  14. positive regulation of neuron apoptotic process Source: RGD
  15. protein dephosphorylation Source: RGD
  16. regulation of synapse structure and activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen related
Short name:
LAR
Gene namesi
Name:Ptprf
Synonyms:Lar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3453. Ptprf.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: RGD
  2. excitatory synapse Source: RGD
  3. growth cone Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular membrane-bounded organelle Source: RGD
  6. membrane Source: RGD
  7. neuronal cell body Source: RGD
  8. neuron projection Source: RGD
  9. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 18981869Receptor-type tyrosine-protein phosphatase FPRO_5000142152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64604.
PRIDEiQ64604.

Expressioni

Gene expression databases

GenevestigatoriQ64604.

Interactioni

Subunit structurei

Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with PTPRF.By similarity

Protein-protein interaction databases

IntActiQ64604. 4 interactions.
STRINGi10116.ENSRNOP00000027271.

Structurei

3D structure databases

ProteinModelPortaliQ64604.
SMRiQ64604. Positions 319-415, 596-719, 814-904, 909-1001, 1325-1893.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12541225ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1276 – 1898623CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1255 – 127521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini232 – 31483Ig-like C2-type 3Add
BLAST
Domaini321 – 41191Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini416 – 51095Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini514 – 60491Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini609 – 70698Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 810100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini811 – 90595Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini909 – 100193Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 108985Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1343 – 1598256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1630 – 1889260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 7710Heparin-bindingBy similarity
Regioni1539 – 15457Substrate bindingBy similarity

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000010250.
InParanoidiQ64604.
KOiK05695.
PhylomeDBiQ64604.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64604 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQIGLSGGVA
60 70 80 90 100
SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR
110 120 130 140 150
DEAIYECTAT NSLGEINTSA KLSVLEEDQL PSGFPTIDMG PQLKVVEKAR
160 170 180 190 200
TATMLCAAGG NPDPEISWFK DFLPVDPASS NGRIKQLRSG ALQIESSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGNVN
260 270 280 290 300
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA
310 320 330 340 350
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY
360 370 380 390 400
GIQYRAAGTD GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP
410 420 430 440 450
SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY
460 470 480 490 500
YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS
510 520 530 540 550
PTIQVKTQQG VPAQPADFQA KAESDTRIQL SWLLPPQERI IKYELVYWAA
560 570 580 590 600
EDEGQQHKVT FDPTSSYTLE DLKPDTLYHF QLAARSDLGV GVFTPTVEAC
610 620 630 640 650
TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD
660 670 680 690 700
GEDRKRHVVD GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL
710 720 730 740 750
VRTDEDVPSG PPRKVEVEPL NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR
760 770 780 790 800
LENGEPRGQP IIQDVMLAEA QETTISGLTP ETTYSITVAA YTTKGDGARS
810 820 830 840 850
KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE LLGYRLQYRR
860 870 880 890 900
ADEARPNTID FGKDDQHFTV TGLHKGATYI FRLAAKNRAG PGEEFEKEIT
910 920 930 940 950
TPEDAPSGFP QNLRVTGLTT STTELAWDPP VLAERNGRIT NYTVVYRDIN
960 970 980 990 1000
SQHELQNVTG DVHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP
1010 1020 1030 1040 1050
MEQVFAKNFR VAAAMKTSVL LSWEVPDSYK SAVPFKILYN GQSVEVDGHS
1060 1070 1080 1090 1100
MRKLIADLQP NTEYSFVLMN RGTSAGGLQH LVSIRTAPDL LPQKPLPASA
1110 1120 1130 1140 1150
FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP RWSTPEELEL
1160 1170 1180 1190 1200
DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDELPETFT LGDKKNYRGF
1210 1220 1230 1240 1250
YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP
1260 1270 1280 1290 1300
EMLWVTGPVL AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH
1310 1320 1330 1340 1350
SSDPVEMRRL NYQTPGMRDH PPIPITDLAD NIERLKANDG LKFSQEYESI
1360 1370 1380 1390 1400
DPGQQFTWEN SNSEVNKPKN RYANVIAYDH SRVLLTSIDG VPGSDYINAN
1410 1420 1430 1440 1450
YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRIATVVMM TRLEEKSRVK
1460 1470 1480 1490 1500
CDQYWPARGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF
1510 1520 1530 1540 1550
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI
1560 1570 1580 1590 1600
VIDAMLERMK HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM
1610 1620 1630 1640 1650
CGHTEVLARN LYAHIQKLGQ VPPGESVTAM ELEFKLLAGS KARASRFISA
1660 1670 1680 1690 1700
NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF LDGYRQQKAY
1710 1720 1730 1740 1750
IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC HQYWPAERSA
1760 1770 1780 1790 1800
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP
1810 1820 1830 1840 1850
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM
1860 1870 1880 1890
RYEGVVDMFQ TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT
Length:1,898
Mass (Da):211,494
Last modified:November 1, 1996 - v1
Checksum:iDF4D7E46F5896F4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1073 – 10731T → S in AAA41510. (PubMed:1918076)Curated
Sequence conflicti1434 – 14341I → T in AAA41510. (PubMed:1918076)Curated
Sequence conflicti1639 – 16391G → N in AAA41510. (PubMed:1918076)Curated
Sequence conflicti1643 – 16442RA → HT in AAA41510. (PubMed:1918076)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11586 mRNA. Translation: AAC37655.1.
M60103 mRNA. Translation: AAA41510.1.
PIRiS46216.
RefSeqiNP_062122.1. NM_019249.1.
UniGeneiRn.11386.

Genome annotation databases

GeneIDi360406.
KEGGirno:360406.
UCSCiRGD:3453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11586 mRNA. Translation: AAC37655.1 .
M60103 mRNA. Translation: AAA41510.1 .
PIRi S46216.
RefSeqi NP_062122.1. NM_019249.1.
UniGenei Rn.11386.

3D structure databases

ProteinModelPortali Q64604.
SMRi Q64604. Positions 319-415, 596-719, 814-904, 909-1001, 1325-1893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64604. 4 interactions.
STRINGi 10116.ENSRNOP00000027271.

Chemistry

BindingDBi Q64604.
ChEMBLi CHEMBL2834.

Proteomic databases

PaxDbi Q64604.
PRIDEi Q64604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360406.
KEGGi rno:360406.
UCSCi RGD:3453. rat.

Organism-specific databases

CTDi 5792.
RGDi 3453. Ptprf.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000010250.
InParanoidi Q64604.
KOi K05695.
PhylomeDBi Q64604.

Miscellaneous databases

NextBioi 672799.

Gene expression databases

Genevestigatori Q64604.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a unique receptor-like protein-tyrosine-phosphatase in the leucocyte-common-antigen-related phosphate family."
    Zhang W.-R., Hashimoto N., Ahmad F., Ding W., Goldstein B.J.
    Biochem. J. 302:39-47(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase."
    Pot D.A., Woodford T.A., Remboutsika E., Haun R.S., Dixon J.E.
    J. Biol. Chem. 266:19688-19696(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1035-1898, FUNCTION.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPTPRF_RAT
AccessioniPrimary (citable) accession number: Q64604
Secondary accession number(s): Q4JFJ1
, Q63294, Q63295, Q63296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3